公开(公告)号：US20150299702A1

公开(公告)日：2015-10-22

申请号：US14648360

申请日：2013-11-29

申请人： Peter Samuel WULFF ,  Mogens TERGÅRD DUCH ,  Shervin BAHRAMI ,  Jørgen KJEMS ,  Hansen Thomas BIRKBALLE

发明人： Jørgen Kjems ,  Hansen Thomas Birkballe

IPC分类号： C12N15/113

CPC分类号： C12N15/113 ,  A61K31/7088 ,  C12N2310/113 ,  C12N2310/51 ,  C12N2310/532 ,  C12N2320/30 ,  C12N2330/10 ,  C12N2330/51 ,  Y02A50/465

摘要： The present invention relates to inhibition of microRNAs (miRNA), other types of RNA and RNA-binding proteins. In particular the present invention relates to nucleic acid sequences that are circular and allow inhibition of the interactions between microRNAs and their RNA target and being resistant to degradation by exonucleases. Also, the present invention relates to nucleic acid sequence that are circular and acts as an RNA blocker or protein decoy.

摘要翻译： 本发明涉及抑制微小RNA（miRNA），其他类型的RNA和RNA结合蛋白。 特别地，本发明涉及环状的核酸序列，并允许抑制微小RNA及其RNA靶标之间的相互作用并且对外源核酸酶的降解具有抗性。 此外，本发明涉及环状并作为RNA阻断剂或蛋白质诱饵的核酸序列。