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    System and method for detection of analytes in exhaled breath
    2.
    发明授权
    System and method for detection of analytes in exhaled breath 有权
    用于检测呼气中分析物的系统和方法

    公开(公告)号：US08368883B2

    公开(公告)日：2013-02-05

    申请号：US13394979

    申请日：2010-09-09

    Applicant: Göran Palmskog ,  Olof Beck ,  Per Ola Andersson

    Inventor： Göran Palmskog ,  Olof Beck ,  Per Ola Andersson

    IPC: G01J3/44

    CPC classification number: G01N21/658 ,  A61B5/082 ,  A61B5/412 ,  G01J3/44 ,  G01N33/497

    Abstract: A sensor for detecting a drug substance (15) from exhaled breath of a subject in-situ. Its collecting surface has a Surface Enhanced Raman Spectroscopy (SERS)-active layer (14) of a SERS-active material. The collecting surface is arranged as an outer surface of a waveguide (12) for contact with exhaled breath, such that at least traces of said drug substance (15) in said exhaled breath can contact said SERS-active layer for read-out of a Raman shift spectrum.

    Abstract translation: 一种用于从现场呼出的呼吸气体检测药物（15）的传感器。 其收集表面具有SERS-活性材料的表面增强拉曼光谱（SERS）活性层（14）。 收集表面被布置为用于与呼出的呼吸接触的波导（12）的外表面，使得所述呼出的呼吸中的至少痕量的所述药物（15）可以接触所述SERS活性层以读出 拉曼位移谱。

    METHOD AND APPARATUS FOR DETECTING PHARMACEUTICALS IN A SAMPLE
    3.
    发明申请
    METHOD AND APPARATUS FOR DETECTING PHARMACEUTICALS IN A SAMPLE 有权
    用于检测样品中药物的方法和装置

    公开(公告)号：US20120032095A1

    公开(公告)日：2012-02-09

    申请号：US13263399

    申请日：2010-03-25

    Applicant: Ian A. Nicholls ,  Bjorn C.G. Karlsson ,  Annika M. Rosengren ,  Per Ola Andersson

    Inventor： Ian A. Nicholls ,  Bjorn C.G. Karlsson ,  Annika M. Rosengren ,  Per Ola Andersson

    IPC: G01N21/64

    CPC classification number: G01N21/6408

    Abstract: A method and apparatus for measuring a vitamin K antagonizing anticoagulant present in a sample (116), arranged to: irradiate (304) the sample (116) with light from a light source (114) for exciting the anticoagulant through its absorption of the light, the excitation of the sample (116) resulting in a fluorescent emission from the sample (116); measure (306) the fluorescent emission from the sample (116); determine (308) a fluorescence lifetime (τ1) of the fluorescent emission of the sample (116); determine (310) an intensity (A1) of the fluorescent emission at the fluorescence lifetime (τ1); and determine (312) a amount (c) of the anticoagulant, as a function of the intensity (A1) of the fluorescent emission at the fluorescence lifetime (τ1).

    Abstract translation: 一种用于测量存在于样品（116）中的维生素K拮抗抗凝血剂的方法和装置，其被布置成：用来自光源（114）的光照射（304）样品（116），以通过其吸收光来激发抗凝血剂 样品（116）的激发导致来自样品（116）的荧光发射; 测量（306）来自样品（116）的荧光发射; 确定（308）样品（116）的荧光发射的荧光寿命（τ1）; 确定（310）在荧光寿命（τ1）下荧光发射的强度（A1）; 并确定（312）抗凝血剂的量（c），作为荧光发射在荧光寿命（τ1）下的强度（A1）的函数。

    Fibre-optic interferometer
    5.
    发明授权
    Fibre-optic interferometer 失效
    光纤干涉仪

    公开(公告)号：US4759627A

    公开(公告)日：1988-07-26

    申请号：US836395

    申请日：1986-03-05

    Applicant: Lars H. Thylen ,  Per-Ola Andersson ,  Sven A. R. Persson

    Inventor： Lars H. Thylen ,  Per-Ola Andersson ,  Sven A. R. Persson

    IPC: G01D5/353 ,  G01B9/02

    CPC classification number: G01D5/35303

    Abstract: The invention relates to a fibre-optic Mach-Zehnder Interferometer for measuring such as change in length. Two light conducting fibres (1,2) are connected to a coherent light source (5). A measurement converter (6), actuated by a measurement quantity (P) changes the length of the optical path and thereby the phase angle for the light wave in one fibre (2). The phase angles for the light waves in the fibres (1, 2) are compared and a corresponding output signal (I) is fed back to compensate for the phase angle change in the measurement converter (6). To make the comparison result (I) independent of the light intensities in the light conducting fibres (1,2) these are connected to an opto-electronic directional coupler (7). This is selected such that the output signal (I) varies as the phase displacement .phi., according to the relationship: I=2.times.A.times.B.times.sin .phi., where A and B are the amplitudes of the light waves in the fibres (1,2). By using the directional coupler (7), the interferometer can be made simple and accurate. The opto-electronic coupler ( 7) allows the use of polarized light, whereby accuracy may be further improved.

    Abstract translation: 本发明涉及用于测量长度变化的光纤马赫 - 曾德干涉仪。 两个导光纤维（1,2）连接到相干光源（5）。 由测量量（P）驱动的测量转换器（6）改变光路的长度，从而改变一个光纤（2）中的光波的相位角。 对纤维（1,2）中的光波的相位角进行比较，并且反馈相应的输出信号（I）以补偿测量转换器（6）中的相位角变化。 为了使比较结果（I）与光导纤维（1,2）中的光强度无关，它们连接到光电定向耦合器（7）。 这被选择为使得输出信号（I）根据关系：I = 2xAxBxsin phi，其中A和B是光纤（1,2）中的光波的幅度，作为相位移位phi变化。 通过使用定向耦合器（7），可以使干涉仪简单准确。 光电耦合器（7）允许使用偏振光，从而可以进一步提高精度。

    Method and apparatus for detecting pharmaceuticals in a sample
    6.
    发明授权
    Method and apparatus for detecting pharmaceuticals in a sample 有权
    用于检测样品中药物的方法和装置

    公开(公告)号：US08841633B2

    公开(公告)日：2014-09-23

    申请号：US13263399

    申请日：2010-03-25

    Applicant: Ian A Nicholls ,  Bjorn C.G. Karlsson ,  Annika M Rosengren ,  Per Ola Andersson

    Inventor： Ian A Nicholls ,  Bjorn C.G. Karlsson ,  Annika M Rosengren ,  Per Ola Andersson

    IPC: G01J1/58 ,  G01N21/64

    CPC classification number: G01N21/6408

    Abstract: A method and apparatus for measuring a vitamin K antagonizing anticoagulant present in a sample (116), arranged to: irradiate (304) the sample (116) with light from a light source (114) for exciting the anticoagulant through its absorption of the light, the excitation of the sample (116) resulting in a fluorescent emission from the sample (116); measure (306) the fluorescent emission from the sample (116); determine (308) a fluorescence lifetime (T1) of the fluorescent emission of the sample (116); determine (310) an intensity (A1) of the fluorescent emission at the fluorescence lifetime (T1); and determine (312) a amount (c) of the anticoagulant, as a function of the intensity (A1) of the fluorescent emission at the fluorescence lifetime (T1).

    Abstract translation: 一种用于测量存在于样品（116）中的维生素K拮抗抗凝血剂的方法和装置，其被布置成：用来自光源（114）的光照射（304）样品（116），以通过其吸收光来激发抗凝血剂 样品（116）的激发导致来自样品（116）的荧光发射; 测量（306）来自样品（116）的荧光发射; 确定（308）样品（116）的荧光发射的荧光寿命（T1）; 确定（310）在荧光寿命（T1）下荧光发射的强度（A1）; 并根据荧光寿命（T1）的荧光发射强度（A1）确定（312）抗凝剂的量（c）。

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