公开(公告)号：US20230265123A1

公开(公告)日：2023-08-24

申请号：US18041289

申请日：2021-08-10

申请人： Peptinovo Biopharma, Inc.

发明人： Reynold Homan

IPC分类号： C07K7/08 ,  A61K9/51 ,  A61P35/00 ,  A61K47/54 ,  A61K51/08 ,  A61K51/04

CPC分类号： C07K7/08 ,  A61K9/5123 ,  A61P35/00 ,  A61K47/554 ,  A61K47/542 ,  A61K51/08 ,  A61K51/0408

摘要： Novel amphiphilic peptide, peptide amphiphile lipid micelles, processes for making peptide amphiphile lipid micelles comprising an amphiphilic peptide and phospholipid and optionally comprising a cargo molecule, and methods of use.

公开(公告)号：US20240189230A1

公开(公告)日：2024-06-13

申请号：US17634975

申请日：2020-08-11

申请人： Peptinovo Biopharma Inc.

发明人： Reynold Homan

IPC分类号： A61K9/107 ,  A61K31/167 ,  A61K31/282 ,  A61K31/337 ,  A61K31/4745 ,  A61K33/243 ,  A61K38/10 ,  A61K38/16 ,  A61K47/24 ,  A61K47/28 ,  A61K47/54 ,  A61K47/69 ,  A61K49/18 ,  A61K51/12 ,  A61P35/00

CPC分类号： A61K9/1075 ,  A61K31/167 ,  A61K31/282 ,  A61K31/337 ,  A61K31/4745 ,  A61K33/243 ,  A61K38/10 ,  A61K38/16 ,  A61K47/24 ,  A61K47/28 ,  A61K47/545 ,  A61K47/6909 ,  A61K49/1809 ,  A61K51/1227 ,  A61P35/00

摘要： The present disclosure provides a method for the treatment or prevention of Chemotherapy-Induced Peripheral Neuropathy (CIPN) in a cancer patient treated with, or to be treated with, a CIPN causing chemotherapeutic agent, the method comprising: administering a therapeutically effective amount of a composition containing a peptide amphiphile lipid micelle (PALM) nanoparticle to the cancer patient, the PALM nanoparticle comprising a PALM containing the CIPN causing chemotherapeutic agent, and wherein the PALM comprises a peptide, and a lipid component comprising sphingomyelin and one or more additional phospholipids.