公开(公告)号：US20060063765A1

公开(公告)日：2006-03-23

申请号：US10509162

申请日：2003-03-27

Applicant: Rachael Ancliff ,  Caroline Cook ,  Colin Eldred ,  Paul Gore ,  Lee Harrison ,  Martin Hayes ,  Simon Hodgson ,  Duncan Judd ,  Suzanne Keeling ,  Xiao Lewell ,  Gail Mills ,  Graeme Robertson ,  Stephen Swanson ,  Andrew Walker ,  Mark Wilkinson

Inventor： Rachael Ancliff ,  Caroline Cook ,  Colin Eldred ,  Paul Gore ,  Lee Harrison ,  Martin Hayes ,  Simon Hodgson ,  Duncan Judd ,  Suzanne Keeling ,  Xiao Lewell ,  Gail Mills ,  Graeme Robertson ,  Stephen Swanson ,  Andrew Walker ,  Mark Wilkinson

IPC: A61K31/537 ,  C07D265/30

CPC classification number: C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Compounds of formula (I): wherein: R1 represents substituted or unsubstituted heteroaryl; Y represents —(CRnaRnb)n—; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 0 to 5; R2 represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R3 and R4 each independently represent hydrogen or C1-6alkyl; R7 represents hydrogen or C1-6alkyl; R8 represents hydrogen or C1-6alkyl; and salts and solvates thereof; are CCR3 antagonists and are thus indicated to be useful in therapy.

Abstract translation: 式（I）的化合物：

公开(公告)号：US20080039444A1

公开(公告)日：2008-02-14

申请号：US11736602

申请日：2007-04-18

Applicant: Paul GORE ,  Ashley HANCOCK ,  Simon HODGSON ,  Leanda KINDON

Inventor： Paul GORE ,  Ashley HANCOCK ,  Simon HODGSON ,  Leanda KINDON

IPC: A61K31/55 ,  A61K31/551 ,  A61P29/00 ,  A61P37/08 ,  C07D223/14

CPC classification number: C07D403/06 ,  C07D237/32 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D471/04

Abstract: The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis.

Abstract translation: 本发明涉及式（I）化合物及其盐，其制备方法，含有它们的组合物及其在治疗各种疾病如过敏性鼻炎中的用途。

公开(公告)号：US20060079525A1

公开(公告)日：2006-04-13

申请号：US11284544

申请日：2005-11-22

Applicant: Rachael Ancliff ,  Caroline Cook ,  Colin Eldred ,  Paul Gore ,  Lee Harrison ,  Simon Hodgson ,  Duncan Judd ,  Suzanne Keeling ,  Xiao Lewell ,  Graeme Robertson ,  Stephen Swanson

Inventor： Rachael Ancliff ,  Caroline Cook ,  Colin Eldred ,  Paul Gore ,  Lee Harrison ,  Simon Hodgson ,  Duncan Judd ,  Suzanne Keeling ,  Xiao Lewell ,  Graeme Robertson ,  Stephen Swanson

IPC: A61K31/537 ,  C07D265/30

CPC classification number: C07D265/30 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: There are provided according to the invention, novel compounds of formula (I) wherein R1, R2, R3, R4, R5, X, a, b and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

Abstract translation: 根据本发明，提供了式（I）的新化合物，其中R 1，R 2，R 3，R 3， 4，R 5，X，a，b和Z如说明书中所定义，制备方法，含有它们的制剂及其在治疗炎性疾病中的用途。

公开(公告)号：US20060058299A1

公开(公告)日：2006-03-16

申请号：US10509417

申请日：2003-03-27

Applicant: Rachael Ancliff ,  Caroline Cook ,  Colin Eldred ,  Paul Gore ,  Lee Harrison ,  Martin Hayes ,  Simon Hodgson ,  Duncan Judd ,  Suzanne Keeling ,  Xiao Lewell ,  Gail Mills ,  Graeme Robertson ,  Stephen Swanson ,  Andrew Walker ,  Mark Wilkinson

Inventor： Rachael Ancliff ,  Caroline Cook ,  Colin Eldred ,  Paul Gore ,  Lee Harrison ,  Martin Hayes ,  Simon Hodgson ,  Duncan Judd ,  Suzanne Keeling ,  Xiao Lewell ,  Gail Mills ,  Graeme Robertson ,  Stephen Swanson ,  Andrew Walker ,  Mark Wilkinson

IPC: C07D265/30 ,  A61K31/537

CPC classification number: C07D265/30 ,  A61K31/5375

Abstract: Compound of formula (I): and salts and solvates thereof, a process for its preparation, pharmaceutical formulations containing it and its use in therapy.

Abstract translation: 式（I）化合物：

公开(公告)号：US20080004295A1

公开(公告)日：2008-01-03

申请号：US11548343

申请日：2006-10-11

Applicant: Paul Gore ,  Vipulkumar Patel ,  Ann Walker

Inventor： Paul Gore ,  Vipulkumar Patel ,  Ann Walker

IPC: A61K31/519 ,  A61P11/00 ,  A61P11/02 ,  A61P19/02 ,  A61P37/08 ,  A61P9/10 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: Pyrrolopyrimidine derivatives of formula (I) are inhibitors of Spleen Tyrosine kinase (Syk) and therefore of potential therapeutic benefit in the treatment of diseases and conditions associated with inappropriate Syk activity, in particular in the treatment of inflammatory and allergic diseases.

Abstract translation: 式（I）的吡咯并嘧啶衍生物是脾脏酪氨酸激酶（Syk）的抑制剂，因此在治疗与不适当的Syk活性相关的疾病和病症方面具有潜在的治疗益处，特别是治疗炎性和过敏性疾病。