公开(公告)号：US20060063765A1

公开(公告)日：2006-03-23

申请号：US10509162

申请日：2003-03-27

Applicant: Rachael Ancliff ,  Caroline Cook ,  Colin Eldred ,  Paul Gore ,  Lee Harrison ,  Martin Hayes ,  Simon Hodgson ,  Duncan Judd ,  Suzanne Keeling ,  Xiao Lewell ,  Gail Mills ,  Graeme Robertson ,  Stephen Swanson ,  Andrew Walker ,  Mark Wilkinson

Inventor： Rachael Ancliff ,  Caroline Cook ,  Colin Eldred ,  Paul Gore ,  Lee Harrison ,  Martin Hayes ,  Simon Hodgson ,  Duncan Judd ,  Suzanne Keeling ,  Xiao Lewell ,  Gail Mills ,  Graeme Robertson ,  Stephen Swanson ,  Andrew Walker ,  Mark Wilkinson

IPC: A61K31/537 ,  C07D265/30

CPC classification number: C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Compounds of formula (I): wherein: R1 represents substituted or unsubstituted heteroaryl; Y represents —(CRnaRnb)n—; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 0 to 5; R2 represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R3 and R4 each independently represent hydrogen or C1-6alkyl; R7 represents hydrogen or C1-6alkyl; R8 represents hydrogen or C1-6alkyl; and salts and solvates thereof; are CCR3 antagonists and are thus indicated to be useful in therapy.

Abstract translation: 式（I）的化合物：

公开(公告)号：US20060019964A1

公开(公告)日：2006-01-26

申请号：US11112048

申请日：2005-04-22

Applicant: Ranchael Ancliff ,  Colin Eldred ,  Yvonne Fogden ,  Ashley Hancock ,  Thomas Heightman ,  Heather Hobbs ,  Simon Hodgson ,  Matthew Lindon ,  David Wilson

Inventor： Ranchael Ancliff ,  Colin Eldred ,  Yvonne Fogden ,  Ashley Hancock ,  Thomas Heightman ,  Heather Hobbs ,  Simon Hodgson ,  Matthew Lindon ,  David Wilson

IPC: A61K31/496 ,  C07D403/02

CPC classification number: C07D211/46

Abstract: 1-{4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl}-4-{[4-(methylsulfonyl)phenyl]carbonyl}piperazine or a derivative thereof.

Abstract translation: 1- {4 - [（1-环丁基-4-哌啶基）氧基]苯基} -4 - {[4-（甲基磺酰基）苯基]羰基}哌嗪或其衍生物。

公开(公告)号：US20060025404A1

公开(公告)日：2006-02-02

申请号：US10531758

申请日：2003-10-14

Applicant: Rachel Ancliff ,  Colin Eldred ,  Yvonne Fogden ,  Ashley Hancock ,  Thomas Heightman ,  Heather Hobbs ,  Simon Hodgson ,  Matthew Lindon ,  David Wilson

Inventor： Rachel Ancliff ,  Colin Eldred ,  Yvonne Fogden ,  Ashley Hancock ,  Thomas Heightman ,  Heather Hobbs ,  Simon Hodgson ,  Matthew Lindon ,  David Wilson

IPC: A61K31/551 ,  A61K31/496

CPC classification number: C07D213/81 ,  C07D209/42 ,  C07D211/46 ,  C07D213/50 ,  C07D213/64 ,  C07D215/40 ,  C07D215/46 ,  C07D215/50 ,  C07D239/28 ,  C07D243/08 ,  C07D265/36 ,  C07D277/62 ,  C07D285/06 ,  C07D295/088 ,  C07D295/185 ,  C07D295/192 ,  C07D295/215 ,  C07D295/26 ,  C07D307/79 ,  C07D307/85 ,  C07D311/84 ,  C07D317/68 ,  C07D333/38 ,  C07D405/06 ,  C07D487/08 ,  C07D491/04

Abstract: The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease.

Abstract translation: 本发明涉及具有药理活性的新颖的哌嗪和吖庚因衍生物，其制备方法，含有它们的组合物及其在治疗包括阿尔茨海默病的神经变性疾病中的用途。

公开(公告)号：US20070191426A1

公开(公告)日：2007-08-16

申请号：US10572913

申请日：2004-09-27

Applicant: Christopher Edlin ,  Colin Eldred ,  Christopher Lunniss ,  Alison Redgrave ,  John Robinson ,  Michael Woodrow

Inventor： Christopher Edlin ,  Colin Eldred ,  Christopher Lunniss ,  Alison Redgrave ,  John Robinson ,  Michael Woodrow

IPC: A61K31/47

CPC classification number: C04B35/632 ,  C07D215/44 ,  C07D401/12 ,  C07D405/12 ,  C07D411/12 ,  C07D417/12

Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof are inhibitors of phosphodiesterase type IV (PDE4) and are of use in the treatment of inflammatory and/or allergic diseases.

Abstract translation: 式（I）化合物或其药学上可接受的盐是IV型磷酸二酯酶（PDE4）的抑制剂，并且可用于治疗炎性和/或过敏性疾病。

公开(公告)号：US20070142373A1

公开(公告)日：2007-06-21

申请号：US10557079

申请日：2004-05-19

Applicant: Ian Baldwin ,  Michael Barker ,  Anthony Dean ,  Colin Eldred ,  Brian Evans ,  Sharon Gough ,  Stephen Guntrip ,  Julie Hamblin ,  Stuart Holman ,  Paul Jones ,  Mika Lindvall ,  Christopher Lunniss ,  Tracy Redfern ,  Alison Redgrave ,  John Robinson ,  Michael Woodrow

Inventor： Ian Baldwin ,  Michael Barker ,  Anthony Dean ,  Colin Eldred ,  Brian Evans ,  Sharon Gough ,  Stephen Guntrip ,  Julie Hamblin ,  Stuart Holman ,  Paul Jones ,  Mika Lindvall ,  Christopher Lunniss ,  Tracy Redfern ,  Alison Redgrave ,  John Robinson ,  Michael Woodrow

IPC: A61K31/5377 ,  A61K31/496 ,  A61K31/4709 ,  C07D413/02 ,  C07D403/02 ,  C07D401/02

CPC classification number: C07D401/12 ,  C07D215/54 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02

Abstract: There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

Abstract translation: 根据本发明提供新的式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 19，R 20和R 34如说明书中所述，其制备方法，含有 他们及其在治疗炎症性疾病中的应用。

公开(公告)号：US20060079525A1

公开(公告)日：2006-04-13

申请号：US11284544

申请日：2005-11-22

Applicant: Rachael Ancliff ,  Caroline Cook ,  Colin Eldred ,  Paul Gore ,  Lee Harrison ,  Simon Hodgson ,  Duncan Judd ,  Suzanne Keeling ,  Xiao Lewell ,  Graeme Robertson ,  Stephen Swanson

Inventor： Rachael Ancliff ,  Caroline Cook ,  Colin Eldred ,  Paul Gore ,  Lee Harrison ,  Simon Hodgson ,  Duncan Judd ,  Suzanne Keeling ,  Xiao Lewell ,  Graeme Robertson ,  Stephen Swanson

IPC: A61K31/537 ,  C07D265/30

CPC classification number: C07D265/30 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: There are provided according to the invention, novel compounds of formula (I) wherein R1, R2, R3, R4, R5, X, a, b and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

Abstract translation: 根据本发明，提供了式（I）的新化合物，其中R 1，R 2，R 3，R 3， 4，R 5，X，a，b和Z如说明书中所定义，制备方法，含有它们的制剂及其在治疗炎性疾病中的用途。

公开(公告)号：US20060058299A1

公开(公告)日：2006-03-16

申请号：US10509417

申请日：2003-03-27

Applicant: Rachael Ancliff ,  Caroline Cook ,  Colin Eldred ,  Paul Gore ,  Lee Harrison ,  Martin Hayes ,  Simon Hodgson ,  Duncan Judd ,  Suzanne Keeling ,  Xiao Lewell ,  Gail Mills ,  Graeme Robertson ,  Stephen Swanson ,  Andrew Walker ,  Mark Wilkinson

Inventor： Rachael Ancliff ,  Caroline Cook ,  Colin Eldred ,  Paul Gore ,  Lee Harrison ,  Martin Hayes ,  Simon Hodgson ,  Duncan Judd ,  Suzanne Keeling ,  Xiao Lewell ,  Gail Mills ,  Graeme Robertson ,  Stephen Swanson ,  Andrew Walker ,  Mark Wilkinson

IPC: C07D265/30 ,  A61K31/537

CPC classification number: C07D265/30 ,  A61K31/5375

Abstract: Compound of formula (I): and salts and solvates thereof, a process for its preparation, pharmaceutical formulations containing it and its use in therapy.

Abstract translation: 式（I）化合物：