公开(公告)号：US09593306B2

公开(公告)日：2017-03-14

申请号：US13434409

申请日：2012-03-29

Applicant: Janet Davis ,  Jiajian Liu ,  Christine Parmenter ,  Pascal Ghislain André Bonnet

Inventor： Janet Davis ,  Jiajian Liu ,  Christine Parmenter ,  Pascal Ghislain André Bonnet

IPC: C12N5/071 ,  C12N5/0735

CPC classification number: C12N5/0606 ,  C12N5/0678 ,  C12N2501/11 ,  C12N2501/119 ,  C12N2501/135 ,  C12N2501/16 ,  C12N2501/165 ,  C12N2501/19 ,  C12N2501/999 ,  C12N2506/02

Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

Abstract translation: 本发明涉及分化多能干细胞的方法。 特别地，本发明涉及将多能干细胞分化成表达定形内胚层谱系特征性标志物的细胞的方法和组合物，其包括在含有足够数量的GDF-8的培养基中培养多能干细胞以引起多能分化 干细胞进入表达定形内胚层谱系特征标志物的细胞。

公开(公告)号：US09593305B2

公开(公告)日：2017-03-14

申请号：US13434370

申请日：2012-03-29

Applicant: Janet Davis ,  Jiajian Liu ,  Christine Parmenter ,  Pascal Ghislain André Bonnet

Inventor： Janet Davis ,  Jiajian Liu ,  Christine Parmenter ,  Pascal Ghislain André Bonnet

IPC: C12N5/071 ,  C12N5/0735

CPC classification number: C12N5/0606 ,  C12N5/0678 ,  C12N2501/11 ,  C12N2501/119 ,  C12N2501/135 ,  C12N2501/16 ,  C12N2501/165 ,  C12N2501/19 ,  C12N2501/999 ,  C12N2506/02

Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

公开(公告)号：US08895601B2

公开(公告)日：2014-11-25

申请号：US13643741

申请日：2011-04-28

Applicant: Gordon Saxty ,  Christopher William Murray ,  Valerio Berdini ,  Gilbert Ebai Besong ,  Christopher Charles Frederick Hamlett ,  Christopher Norbert Johnson ,  Steven John Woodhead ,  David Charles Rees ,  Laurence Anne Mevellec ,  Patrick René Angibaud ,  Eddy Jean Edgard Freyne ,  Timothy Pietro Suren Perera ,  Ronaldus Arnodus Hendrika Joseph Gilissen ,  Berthold Wroblowski ,  Jean Fernand Armand Lacrampe ,  Alexandra Papanikos ,  Oliver Alexis Georges Querolle ,  Elisabeth Thérèse Jeanne Pasquier ,  Isabelle Noëlle Constance Pilatte ,  Pascal Ghislain André Bonnet ,  Werner Constant Johan Embrechts ,  Rhalid Akkari ,  Lieven Meerpoel

Inventor： Gordon Saxty ,  Christopher William Murray ,  Valerio Berdini ,  Gilbert Ebai Besong ,  Christopher Charles Frederick Hamlett ,  Christopher Norbert Johnson ,  Steven John Woodhead ,  David Charles Rees ,  Laurence Anne Mevellec ,  Patrick René Angibaud ,  Eddy Jean Edgard Freyne ,  Timothy Pietro Suren Perera ,  Ronaldus Arnodus Hendrika Joseph Gilissen ,  Berthold Wroblowski ,  Jean Fernand Armand Lacrampe ,  Alexandra Papanikos ,  Oliver Alexis Georges Querolle ,  Elisabeth Thérèse Jeanne Pasquier ,  Isabelle Noëlle Constance Pilatte ,  Pascal Ghislain André Bonnet ,  Werner Constant Johan Embrechts ,  Rhalid Akkari ,  Lieven Meerpoel

IPC: A61K31/415 ,  C07D231/10 ,  C07D231/12 ,  C07D405/14 ,  C07D403/04 ,  C07D487/08 ,  C07D413/14 ,  C07D403/14 ,  C07D409/14

CPC classification number: C07D403/04 ,  A61K31/498 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D487/08 ,  C07D491/113 ,  C07F9/6524

Abstract: The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract translation: 本发明涉及新的喹喔啉衍生物化合物，包含所述化合物的药物组合物，用于制备所述化合物的方法和所述化合物在治疗疾病中的用途。 癌症。

公开(公告)号：US20130072457A1

公开(公告)日：2013-03-21

申请号：US13643741

申请日：2011-04-28

Applicant: Gordon Saxty ,  Christopher William Murray ,  Valerio Berdini ,  Gilbert Ebai Besong ,  Christopher Charles Frederick Hamlett ,  Christopher Norbert Johnson ,  Steven John Woodhead ,  Michael Reader ,  David Charles Rees ,  Laurence Anne Mevellec ,  Patrick René Angibaud ,  Eddy Jean Edgard Freyne ,  Tom Cornelis Hortense Govaerts ,  Johan Erwin Edmond Weerts ,  Timothy Pietro Suren Perera ,  Ronaldus Arnodus Hendrika Joseph Gilissen ,  Berthold Wroblowski ,  Jean Fernand Armand Lacrampe ,  Alexandra Papanikos ,  Oliver Alexis Georges Querolle ,  Elisabeth Thérèse Jeanne Pasquier ,  Isabelle Noëlle Constance Pilatte ,  Pascal Ghislain André Bonnet ,  Werner Constant Johan Embrechts ,  Rhalid Akkari ,  Lieven Meerpoel

Inventor： Gordon Saxty ,  Christopher William Murray ,  Valerio Berdini ,  Gilbert Ebai Besong ,  Christopher Charles Frederick Hamlett ,  Christopher Norbert Johnson ,  Steven John Woodhead ,  Michael Reader ,  David Charles Rees ,  Laurence Anne Mevellec ,  Patrick René Angibaud ,  Eddy Jean Edgard Freyne ,  Tom Cornelis Hortense Govaerts ,  Johan Erwin Edmond Weerts ,  Timothy Pietro Suren Perera ,  Ronaldus Arnodus Hendrika Joseph Gilissen ,  Berthold Wroblowski ,  Jean Fernand Armand Lacrampe ,  Alexandra Papanikos ,  Oliver Alexis Georges Querolle ,  Elisabeth Thérèse Jeanne Pasquier ,  Isabelle Noëlle Constance Pilatte ,  Pascal Ghislain André Bonnet ,  Werner Constant Johan Embrechts ,  Rhalid Akkari ,  Lieven Meerpoel

IPC: C07D403/04 ,  C07D405/14 ,  C07D491/113 ,  C07D401/14 ,  C07D413/14 ,  A61K31/5377 ,  C07D487/08 ,  C07F9/6558 ,  A61K31/675 ,  C07D491/107 ,  C07D471/04 ,  C07D403/14 ,  A61K31/506 ,  A61P35/00 ,  A61K31/498

CPC classification number: C07D403/04 ,  A61K31/498 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D487/08 ,  C07D491/113 ,  C07F9/6524

Abstract: The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract translation: 本发明涉及新的喹喔啉衍生物化合物，包含所述化合物的药物组合物，用于制备所述化合物的方法和所述化合物在治疗疾病中的用途。 癌症。

公开(公告)号：US20120190111A1

公开(公告)日：2012-07-26

申请号：US13434370

申请日：2012-03-29

Applicant: Janet Davis ,  Jiajian Liu ,  Christine Parmenter ,  Pascal Ghislain André Bonnet

Inventor： Janet Davis ,  Jiajian Liu ,  Christine Parmenter ,  Pascal Ghislain André Bonnet

IPC: C12N5/071

CPC classification number: C12N5/0606 ,  C12N5/0678 ,  C12N2501/11 ,  C12N2501/119 ,  C12N2501/135 ,  C12N2501/16 ,  C12N2501/165 ,  C12N2501/19 ,  C12N2501/999 ,  C12N2506/02

Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

公开(公告)号：US20120190112A1

公开(公告)日：2012-07-26

申请号：US13434392

申请日：2012-03-29

Applicant: Janet Davis ,  Jiajian Liu ,  Christine Parmenter ,  Pascal Ghislain André Bonnet

Inventor： Janet Davis ,  Jiajian Liu ,  Christine Parmenter ,  Pascal Ghislain André Bonnet

IPC: C12N5/07

Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

公开(公告)号：US20120041000A1

公开(公告)日：2012-02-16

申请号：US13264596

申请日：2010-04-15

Applicant: Gordon Saxty ,  Valerio Berdini ,  Christopher William Murray ,  Eddy Jean Edgard Freyne ,  Yannick Aimé Eddy Ligny ,  Pascal Ghislain André Bonnet ,  Berthold Wroblowski ,  Alexandra Papanikos

Inventor： Gordon Saxty ,  Valerio Berdini ,  Christopher William Murray ,  Eddy Jean Edgard Freyne ,  Yannick Aimé Eddy Ligny ,  Pascal Ghislain André Bonnet ,  Berthold Wroblowski ,  Alexandra Papanikos

IPC: A61K31/437 ,  A61K31/506 ,  A61P35/00 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: The invention relates to new bicyclic heterocyclyl derivatives of formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract translation: 本发明涉及式（I）的新的双环杂环基衍生物，包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途，例如， 癌症。

公开(公告)号：US08722687B2

公开(公告)日：2014-05-13

申请号：US13264596

申请日：2010-04-15

Applicant: Gordon Saxty ,  Valerio Berdini ,  Christopher William Murray ,  Eddy Jean Edgard Freyne ,  Yannick Aimé Eddy Ligny ,  Pascal Ghislain André Bonnet ,  Berthold Wroblowski ,  Alexandra Papanikos

Inventor： Gordon Saxty ,  Valerio Berdini ,  Christopher William Murray ,  Eddy Jean Edgard Freyne ,  Yannick Aimé Eddy Ligny ,  Pascal Ghislain André Bonnet ,  Berthold Wroblowski ,  Alexandra Papanikos

IPC: C07D239/42 ,  C07D401/04 ,  A61K31/44 ,  A01N43/42 ,  C07D513/02 ,  C07D515/02 ,  C07D401/00 ,  C07D403/00 ,  C07D405/00 ,  C07D409/00 ,  C07D411/00 ,  C07D413/00

CPC classification number: C07D471/04

Abstract: The invention relates to new bicyclic heterocyclyl derivatives of formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract translation: 本发明涉及式（I）的新的双环杂环基衍生物，包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途，例如， 癌症。

公开(公告)号：US08318929B2

公开(公告)日：2012-11-27

申请号：US12921499

申请日：2009-03-09

Applicant: Peter Jacobus Johannes Antonius Buijnsters ,  Marc Gustaaf Celine Verdonck ,  Kristof Van Emelen ,  Pascal Ghislain André Bonnet

Inventor： Peter Jacobus Johannes Antonius Buijnsters ,  Marc Gustaaf Celine Verdonck ,  Kristof Van Emelen ,  Pascal Ghislain André Bonnet

IPC: C07D345/00

CPC classification number: C07D471/08 ,  C07D471/18 ,  C07D471/22 ,  C07D498/08 ,  C07D498/18

Abstract: The present invention relates to compounds of Formula (Ia) or (Ib), the N-oxide forms, pharmaceutically acceptable addition salts, quaternary amines, stereoisomers, tautomers, racemics, metabolites, prodrugs, hydrates, or solvates thereof, wherein Y1, m, n, R1; X1; X2; R2; X3; X4; R3; and R4 have the meaning defined in the claims. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to compounds that are kinase inhibitors useful for the treatment of disease states mediated by kinase, especially PLK4, in particular such compounds that are useful in the treatment of pathological processes which involve an aberrant cellular proliferation, such as tumor growth, rheumatoid arthritis, restenosis and atherosclerosis.

Abstract translation: 本发明涉及式（Ia）或（Ib）的化合物，N-氧化物形式，药学上可接受的加成盐，季胺，立体异构体，互变异构体，外消旋学，代谢物，前药，水合物或溶剂化物，其中Y1， ，n，R1; X1; X2; R2; X3; X4; R3; 和R4具有权利要求中限定的含义。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在治疗中的用途。 本发明特别涉及可用于治疗由激酶，特别是PLK4介导的疾病状态的激酶抑制剂的化合物，特别是可用于治疗涉及异常细胞增殖的病理过程的化合物，例如肿瘤生长，类风湿 关节炎，再狭窄和动脉粥样硬化。

公开(公告)号：US08318731B2

公开(公告)日：2012-11-27

申请号：US12670670

申请日：2008-07-25

Applicant: Gaston Stanislas Marcella Diels ,  Peter Ten Holte ,  Eddy Jean Edgard Freyne ,  Thierry Andre Regis Grand-Perret ,  Kristof Van Emelen ,  Werner Constant Johan Embrechts ,  Pascal Ghislain André Bonnet

Inventor： Gaston Stanislas Marcella Diels ,  Peter Ten Holte ,  Eddy Jean Edgard Freyne ,  Thierry Andre Regis Grand-Perret ,  Kristof Van Emelen ,  Werner Constant Johan Embrechts ,  Pascal Ghislain André Bonnet

IPC: C07D487/08 ,  C07D498/08 ,  A61K31/529 ,  A61P35/02

CPC classification number: C07D498/08 ,  C07D487/08

Abstract: The present invention relates to compounds or pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to compounds that are polo-like kinase (PLKs) inhibitors useful for the treatment of disease states mediated by PLK, especially PLK4, in particular such compounds that are useful in the treatment of pathological processes which involve an aberrant cellular proliferation, such as tumor growth, rheumatoid arthritis, restenosis and atherosclerosis.

Abstract translation: 本发明涉及其化合物或药学上可接受的盐，其制备方法，含有它们的药物组合物及其在治疗中的用途。 本发明特别涉及可用于治疗由PLK，特别是PLK4介导的疾病状态的polo样激酶（PLK）抑制剂的化合物，特别是可用于治疗涉及异常细胞增殖的病理过程的此类化合物， 如肿瘤生长，类风湿关节炎，再狭窄和动脉粥样硬化。