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1.发明授权公开(公告)号：US08859582B2
公开(公告)日：2014-10-14
申请号：US13275752
申请日：2011-10-18
Applicant: Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong
Inventor： Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong
IPC: A01N43/42 , A61K31/44 , C07D513/02 , C07D515/02 , C07D471/04
CPC classification number: C07D471/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, q, A, B, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及式（I）的新的双环杂环衍生物化合物：其中R1，q，A，B，X1，X2，X3，X4，X5和R2如本文所定义，包含所述化合物的药物组合物和使用 的所述化合物治疗疾病，例如 癌症。
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公开(公告)号：US08685980B2
公开(公告)日：2014-04-01
申请号：US13060154
申请日：2009-08-20
Applicant: Gilbert Ebai Besong , Christopher Thomas Brain , Clinton Alan Brooks , Miles Stuart Congreve , Claudio Dagostin , Guo He , Ying Hou , Steven Howard , Yue Li , Yipin Lu , Paul Neil Mortenson , Troy D. Smith , Moo Je Sung , Steven John Woodhead , Wojciech Wrona , Bharat Lagu
Inventor： Gilbert Ebai Besong , Christopher Thomas Brain , Clinton Alan Brooks , Miles Stuart Congreve , Claudio Dagostin , Guo He , Ying Hou , Steven Howard , Yue Li , Yipin Lu , Paul Neil Mortenson , Troy D. Smith , Moo Je Sung , Steven John Woodhead , Wojciech Wrona , Bharat Lagu
IPC: C07D487/04 , A61K31/519 , A61P35/00 , A61P29/00
CPC classification number: C07D487/04 , A61K31/519 , C07D487/08
Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.
Abstract translation: 所公开的化合物涉及蛋白激酶相关病症的治疗和疗法。 还需要可用于治疗或预防或改善癌症，移植排斥和自身免疫性疾病的一种或多种症状的化合物。 此外，需要使用本文提供的化合物调节蛋白激酶如CDK1，CDK2，CDK4，CDK5，CDK6，CDK7，CDK8和CDK9的活性的方法。
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3.发明授权公开(公告)号：US08859583B2
公开(公告)日：2014-10-14
申请号：US13275786
申请日：2011-10-18
Applicant: Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong , Maria Grazia Carr
Inventor： Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong , Maria Grazia Carr
IPC: A01N43/42 , A61K31/44 , C07D513/02 , C07D515/02 , C07D487/04 , C07D471/04
CPC classification number: C07D471/04 , C07D487/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, A, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及式（I）的新的双环杂环衍生物化合物：其中R1，A，X1，X2，X3，X4，X5和R2如本文所定义，包含所述化合物的药物组合物和所述化合物在 疾病的治疗，例如 癌症。
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4.发明申请SUBSTITUTED BENZOPYRAZIN DERIVATIVES AS FGFR KINASE INHIBITORS FOR THE TREATMENT OF CANCER DISEASES 有权作为FGFR激酶抑制剂治疗癌症疾病的替代苯并噻嗪衍生物公开(公告)号：US20130267525A1
公开(公告)日：2013-10-10
申请号：US13990193
申请日：2011-11-29
Applicant: Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Steven John Woodhead , Yannick Aime Eddy Ligny , Patrick René Angibaud
Inventor： Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Steven John Woodhead , Yannick Aime Eddy Ligny , Patrick René Angibaud
IPC: C07D403/04 , C07D401/14 , C07D403/14
CPC classification number: C07D403/04 , C07D401/14 , C07D403/14
Abstract: The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及新的喹喔啉衍生物化合物，包含所述化合物的药物组合物，用于制备所述化合物的方法和所述化合物在治疗疾病中的用途。 癌症。
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5.发明申请公开(公告)号：US20120035153A1
公开(公告)日：2012-02-09
申请号：US13275786
申请日：2011-10-18
Applicant: Gordon SAXTY , Valerio BERDINI , Christopher William MURRAY , Charlotte Mary GRIFFITHS-JONES , Emma VICKERSTAFFE , Gilbert Ebai BESONG , Maria Grazia CARR
Inventor： Gordon SAXTY , Valerio BERDINI , Christopher William MURRAY , Charlotte Mary GRIFFITHS-JONES , Emma VICKERSTAFFE , Gilbert Ebai BESONG , Maria Grazia CARR
IPC: A61K31/519 , A61P35/00 , C07D487/04 , C07D471/04 , A61K31/437
CPC classification number: C07D471/04 , C07D487/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, A, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及式（I）的新的双环杂环衍生物化合物：其中R1，A，X1，X2，X3，X4，X5和R2如本文所定义，包含所述化合物的药物组合物和所述化合物在 疾病的治疗，例如 癌症。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20100286113A1
公开(公告)日：2010-11-11
申请号：US12682478
申请日：2008-10-10
Applicant: Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong
Inventor： Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong
IPC: A61K31/437 , C07D471/04 , C07D487/04 , A61P35/00
CPC classification number: C07D471/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, q, A, B, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及式（I）的新的双环杂环衍生物化合物：其中R1，q，A，B，X1，X2，X3，X4，X5和R2如本文所定义，包含所述化合物的药物组合物和使用 的所述化合物治疗疾病，例如 癌症。
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公开(公告)号：US09145394B2
公开(公告)日：2015-09-29
申请号：US13990193
申请日：2011-11-29
Applicant: Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Steven John Woodhead , Yannick Aime Eddy Ligny , Patrick René Angibaud
Inventor： Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Steven John Woodhead , Yannick Aime Eddy Ligny , Patrick René Angibaud
IPC: A61K31/498 , C07D241/40 , C07D403/04 , C07D401/14 , C07D403/14
Abstract: The invention relates to new quinoxaline derivative compounds of formula (I), to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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![Imidazo[1,2-a]pyridine compounds for use in treating cancer](/abs-image/US/2013/08/20/US08513276B2/abs.jpg.150x150.jpg)
公开(公告)号：US08513276B2
公开(公告)日：2013-08-20
申请号：US12520333
申请日：2007-12-21
Applicant: Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , Miles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
Inventor： Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , Miles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
IPC: C07D471/04 , A61K31/437 , C07D487/04 , A61K31/519 , A61P35/00
CPC classification number: C07D471/04 , C07D487/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of Formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer. The compounds of Formula (I) are inhibitors of FGFR, VEGFR or PDGFR.
Abstract translation: 本发明涉及式（I）的新的双环杂环衍生物化合物，包含所述化合物的药物组合物以及所述化合物在治疗疾病中的用途。 癌症。 式（I）的化合物是FGFR，VEGFR或PDGFR的抑制剂。
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公开(公告)号：US20100120761A1
公开(公告)日：2010-05-13
申请号：US12520481
申请日：2007-12-21
Applicant: Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , MIles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
Inventor： Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , MIles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
IPC: A61K31/437 , C07D471/04 , C07D487/04 , A61K31/496 , A61K31/5377 , A61K31/519 , A61P35/00
CPC classification number: C07D487/04 , A61K31/437 , C07D471/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及新的双环杂环衍生物化合物，包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。 癌症。
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公开(公告)号：US20100093718A1
公开(公告)日：2010-04-15
申请号：US12520333
申请日：2007-12-21
Applicant: Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , Miles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
Inventor： Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , Miles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
IPC: A61K31/5377 , C07D401/14 , A61K31/496 , C07D413/14 , C07D471/02 , A61K31/437 , C07D487/02 , A61K31/519 , A61P35/00
CPC classification number: C07D471/04 , C07D487/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of Formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer The compounds of Formula (I) are inhibitors of FGFR, VEGFR or PDGFR.
Abstract translation: 本发明涉及式（I）的新的双环杂环衍生物化合物，包含所述化合物的药物组合物以及所述化合物在治疗疾病中的用途。 癌症化学式（I）的化合物是FGFR，VEGFR或PDGFR的抑制剂。
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