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公开(公告)号：US20250009760A1
公开(公告)日：2025-01-09
申请号：US18893805
申请日：2024-09-23
Applicant: Oculis Operations Sàrl
Inventor： Thorsteinn LOFTSSON , Zoltán FÜLÖP
IPC: A61K31/573 , A61K9/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/40 , A61P27/02 , A61P29/00
Abstract: The present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a drug which is prone to oxidation, said method comprising the addition of an additive to prevent oxidation of the drug which is prone to oxidation. In particular, the present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a corticosteroid, said method comprising the addition of an additive to prevent oxidation of the corticosteroid. The present disclosure also relates to a composition comprising a corticosteroid and an additive to prevent oxidation of the corticosteroid.
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公开(公告)号：US20250009759A1
公开(公告)日：2025-01-09
申请号：US18893798
申请日：2024-09-23
Applicant: Oculis Operations Sàrl
Inventor： Thorsteinn LOFTSSON , Zoltán FÜLÖP
IPC: A61K31/573 , A61K9/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/40 , A61P27/02 , A61P29/00
Abstract: The present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a drug which is prone to oxidation, said method comprising the addition of an additive to prevent oxidation of the drug which is prone to oxidation. In particular, the present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a corticosteroid, said method comprising the addition of an additive to prevent oxidation of the corticosteroid. The present disclosure also relates to a composition comprising a corticosteroid and an additive to prevent oxidation of the corticosteroid.
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公开(公告)号：US20240390515A1
公开(公告)日：2024-11-28
申请号：US18792377
申请日：2024-08-01
Applicant: Oculis Operations Sàrl
Inventor： Thorsteinn Loftsson , Frédéric Pilotaz
Abstract: The present invention relates to aqueous cyclodextrin compositions containing drug/cyclodextrin complexes and sorbic acid or a pharmaceutically acceptable sorbate that exhibit a superior antimicrobial preservation effect at a low preservative concentration, and to an aqueous eye drop microsuspension containing solid drug/cyclodextrin complexes and sorbic acid or a pharmaceutically acceptable sorbate, which is suitable as a multidose formulation.
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4.发明授权公开(公告)号：US12233133B2
公开(公告)日：2025-02-25
申请号：US18517529
申请日：2023-11-22
Applicant: Oculis Operations Sàrl
Inventor： Thorsteinn Loftsson , Zoltán Fülöp
IPC: A61K47/69 , A61K9/00 , A61K9/08 , A61K9/10 , A61K9/14 , A61K9/50 , A61K9/51 , A61K31/4184 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/34 , A61K47/38 , A61P27/02 , A61K47/40
Abstract: The present disclosure relates to ophthalmic compositions containing solid complexes of active pharmaceutical ingredient and cyclodextrin, to their method of preparation and their uses. The compositions can include an active agent drug/cyclodextrin complex substantially dissolved in an aqueous eye drop vehicle. The ophthalmic composition is generally in the form of a microsuspension including an active agent complex having a diameter of less than about 100 μm.
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公开(公告)号：US20250009758A1
公开(公告)日：2025-01-09
申请号：US18893796
申请日：2024-09-23
Applicant: Oculis Operations Sàrl
Inventor： Thorsteinn LOFTSSON , Zoltán FÜLÖP
IPC: A61K31/573 , A61K9/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/40 , A61P27/02 , A61P29/00
Abstract: The present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a drug which is prone to oxidation, said method comprising the addition of an additive to prevent oxidation of the drug which is prone to oxidation. In particular, the present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a corticosteroid, said method comprising the addition of an additive to prevent oxidation of the corticosteroid. The present disclosure also relates to a composition comprising a corticosteroid and an additive to prevent oxidation of the corticosteroid.
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Patent Agency Ranking
公开(公告)号：US12097209B2
公开(公告)日：2024-09-24
申请号：US17624311
申请日：2020-06-30
Applicant: Oculis Operations Sàrl
Inventor： Thorsteinn Loftsson , Zoltán Fülöp
IPC: A61K31/573 , A61K9/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/40 , A61P27/02 , A61P29/00
CPC classification number: A61K31/573 , A61K9/0048 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/40 , A61P27/02 , A61P29/00
Abstract: A method is described of stabilizing the pH of an aqueous composition including a drug that is prone to oxidation. The method includes adding an additive to prevent oxidation of the drug that is prone to oxidation. Also described, is a method of stabilizing the pH of an aqueous composition including a corticosteroid, the method including adding an additive to prevent oxidation of the corticosteroid. Further, a composition is described that includes a corticosteroid and an additive to prevent oxidation of the corticosteroid.
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公开(公告)号：US12090161B2
公开(公告)日：2024-09-17
申请号：US18383993
申请日：2023-10-26
Applicant: Oculis Operations Sàrl
Inventor： Thorsteinn Loftsson , Zoltan Fulop
IPC: A61K31/573 , A61K9/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/40 , A61P27/02 , A61P29/00
CPC classification number: A61K31/573 , A61K9/0048 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/40 , A61P27/02 , A61P29/00
Abstract: The present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a drug which is prone to oxidation, said method comprising the addition of an additive to prevent oxidation of the drug which is prone to oxidation. In particular, the present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a corticosteroid, said method comprising the addition of an additive to prevent oxidation of the corticosteroid. The present disclosure also relates to a composition comprising a corticosteroid and an additive to prevent oxidation of the corticosteroid.
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公开(公告)号：US20250009762A1
公开(公告)日：2025-01-09
申请号：US18893810
申请日：2024-09-23
Applicant: Oculis Operations Sàrl
Inventor： Thorsteinn LOFTSSON , Zoltán FÜLÖP
IPC: A61K31/573 , A61K9/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/40 , A61P27/02 , A61P29/00
Abstract: The present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a drug which is prone to oxidation, said method comprising the addition of an additive to prevent oxidation of the drug which is prone to oxidation. In particular, the present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a corticosteroid, said method comprising the addition of an additive to prevent oxidation of the corticosteroid. The present disclosure also relates to a composition comprising a corticosteroid and an additive to prevent oxidation of the corticosteroid.
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公开(公告)号：US20250009761A1
公开(公告)日：2025-01-09
申请号：US18893806
申请日：2024-09-23
Applicant: Oculis Operations Sàrl
Inventor： Thorsteinn LOFTSSON , Zoltán FÜLÖP
IPC: A61K31/573 , A61K9/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/40 , A61P27/02 , A61P29/00
Abstract: The present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a drug which is prone to oxidation, said method comprising the addition of an additive to prevent oxidation of the drug which is prone to oxidation. In particular, the present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a corticosteroid, said method comprising the addition of an additive to prevent oxidation of the corticosteroid. The present disclosure also relates to a composition comprising a corticosteroid and an additive to prevent oxidation of the corticosteroid.
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公开(公告)号：US20250009757A1
公开(公告)日：2025-01-09
申请号：US18893790
申请日：2024-09-23
Applicant: Oculis Operations Sàrl
Inventor： Thorsteinn LOFTSSON , Zoltán FÜLÖP
IPC: A61K31/573 , A61K9/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/40 , A61P27/02 , A61P29/00
Abstract: The present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a drug which is prone to oxidation, said method comprising the addition of an additive to prevent oxidation of the drug which is prone to oxidation. In particular, the present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a corticosteroid, said method comprising the addition of an additive to prevent oxidation of the corticosteroid. The present disclosure also relates to a composition comprising a corticosteroid and an additive to prevent oxidation of the corticosteroid.
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