公开(公告)号：US20170240567A1

公开(公告)日：2017-08-24

申请号：US15519740

申请日：2015-10-21

申请人： Mark E. Scott ,  David Guerin ,  Danielle Molinari ,  Sam Kattar ,  Peter Fuller ,  Christopher Dinsmore ,  Normon Kong ,  Yunfeng Bai ,  Jianmin FU ,  Yumei Liu ,  Zhixiang Zheng

发明人： Mark E. Scott ,  David Guerin ,  Danielle Molinari ,  Sam Kattar ,  Peter Fuller ,  Christopher Dinsmore ,  Normon Kong ,  Yunfeng Bai ,  Jianmin FU ,  Yumei Liu ,  Zhixiang Zheng

IPC分类号： C07D519/00 ,  A61K31/4545 ,  A61K31/55 ,  A61K31/538 ,  A61K31/541 ,  A61K31/554 ,  A61K31/553 ,  C07D471/04 ,  A61K31/5377

CPC分类号： C07D519/00 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K31/55 ,  A61K31/553 ,  A61K31/554 ,  A61P11/06 ,  A61P19/02 ,  A61P35/00 ,  C07D471/04

摘要： The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. The present invention provides novel compounds which are inhibitors of JAKs. The invention also provides a method for the treatment and prevention of JAK-mediated diseases and disorders using the novel compounds, as well as pharmaceutical compositions containing the compounds.