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    IDO inhibitors
    2.
    发明授权
    IDO inhibitors 有权

    公开(公告)号：US10233190B2

    公开(公告)日：2019-03-19

    申请号：US15800190

    申请日：2017-11-01

    Applicant: NewLink Genetics Corporation

    Inventor： Mario Mautino ,  Sanjeev Kumar ,  Jesse Waldo ,  Firoz Jaipuri ,  Tanay Kesharwani ,  Xiaoxia Zhang

    IPC: C07D487/04 ,  C07F9/6561

    Abstract: Presently provided are IDO inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.

    Tricyclic Compounds as Inhibitors of Immunosuppression Mediated By Tryptophan Metabolization
    3.
    发明申请
    Tricyclic Compounds as Inhibitors of Immunosuppression Mediated By Tryptophan Metabolization 有权
    三环化合物作为由色氨酸代谢介导的免疫抑制剂的抑制剂

    公开(公告)号：US20160060266A1

    公开(公告)日：2016-03-03

    申请号：US14774450

    申请日：2014-03-10

    Applicant: NEWLINK GENETICS CORPORATION

    Inventor： Sanjeev Kumar ,  Jesse Waldo ,  Firoz Jaipuri ,  Mario Mautino

    IPC: C07D487/04

    CPC classification number: C07D487/04 ,  C07D235/02

    Abstract: Presently provided are inhibitors of IDO and TDO and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase and tryptophan 2,3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosuppression associated with an infectious disease.

    Abstract translation: 目前提供的可用于调节吲哚胺2,3-双加氧酶和色氨酸2,3双加氧酶活性的IDO和TDO及其药物组合物的抑制剂; 治疗免疫抑制; 治疗受抑于色氨酸降解的医学病症; 提高抗癌治疗的有效性，包括施用抗癌剂; 治疗与癌症有关的肿瘤特异性免疫抑制; 并治疗与感染性疾病相关的免疫抑制。

    IDO Inhibitors
    5.
    发明申请
    IDO Inhibitors 审中-公开
    IDO抑制剂

    公开(公告)号：US20130289083A1

    公开(公告)日：2013-10-31

    申请号：US13801268

    申请日：2013-03-13

    Applicant: NewLink Genetics Corporation

    Inventor： Mario Mautino ,  Firoz Jaipuri ,  Agnieszka Marcinowicz-Flick ,  Tanay Kesharwani ,  Jesse Waldo

    IPC: C07D333/56 ,  C07D307/80 ,  C07D277/64

    CPC classification number: C07D333/56 ,  A61K31/138 ,  A61K31/506 ,  C07C259/06 ,  C07C311/48 ,  C07C327/44 ,  C07C327/48 ,  C07C333/20 ,  C07D209/14 ,  C07D209/18 ,  C07D213/40 ,  C07D215/26 ,  C07D253/07 ,  C07D261/20 ,  C07D263/22 ,  C07D277/36 ,  C07D277/64 ,  C07D279/06 ,  C07D307/80 ,  C07D307/81 ,  C07D333/58 ,  C07D333/60 ,  C07D335/06 ,  C07D401/06 ,  C07D405/12 ,  C07D409/12 ,  C07D417/06 ,  C07D417/12 ,  Y02A50/409 ,  Y02A50/465

    Abstract: Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; and (f) treating immunsupression associated with an infectious disease, e.g., HIV-1 infection, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount a compound as described in one of the aspects described herein.

    Abstract translation: 目前提供的是（a）调节吲哚胺2,3-双加氧酶的活性的方法，包括使吲哚胺2,3-双加氧酶与调节有效量的化合物接触，如本文所述的一个方面所述; （b）在有需要的受试者中治疗吲哚胺2,3-双加氧酶（IDO）介导的免疫抑制，包括施用有效的吲哚胺2,3-双加氧酶抑制量的本文所述方面之一所述的化合物; （c）治疗受抑于吲哚胺-2,3-双加氧酶的酶活性的医学病症，包括给予有效的吲哚胺2,3-双加氧酶抑制量的本文所述方面之一所述的化合物; （d）增强抗癌治疗的有效性，包括给予本文所述方面之一所述的抗癌剂和化合物; （e）治疗与癌症相关的肿瘤特异性免疫抑制，包括施用有效的吲哚胺2,3-双加氧酶抑制量的本文所述方面之一所述的化合物; 和（f）治疗与感染性疾病例如HIV-1感染相关的免疫抑制，包括给予有效的吲哚胺2,3-双加氧酶抑制量的化合物，如本文所述方面之一所述。

    IDO Inhibitors
    6.
    发明申请
    IDO Inhibitors 审中-公开

    公开(公告)号：US20180118753A1

    公开(公告)日：2018-05-03

    申请号：US15800190

    申请日：2017-11-01

    Applicant: NewLink Genetics Corporation

    Inventor： Mario Mautino ,  Sanjeev Kumar ,  Jesse Waldo ,  Firoz Jaipuri ,  Tanay Kesharwani ,  Xiaoxia Zhang

    IPC: C07D487/04 ,  C07F9/6561

    CPC classification number: C07D487/04 ,  C07F9/6561

    Abstract: Presently provided are IDO inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.

    IDO Inhibitors
    7.
    发明申请
    IDO Inhibitors 有权
    IDO抑制剂

    公开(公告)号：US20160362412A1

    公开(公告)日：2016-12-15

    申请号：US15181062

    申请日：2016-08-26

    Applicant: NewLink Genetics Corporation

    Inventor： Mario Mautino ,  Sanjeev Kumar ,  Jesse Waldo ,  Firoz Jaipuri ,  Tanay Kesharwani ,  Xiaoxia Zhang

    IPC: C07D487/04 ,  C07F9/6561

    CPC classification number: C07D487/04 ,  C07F9/6561

    Abstract: Presently provided are IDO inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.

    Abstract translation: 目前提供的是可用于调节吲哚胺2,3-双加氧酶活性的IDO抑制剂及其药物组合物; 治疗吲哚胺2,3-双加氧酶（IDO）介导的免疫抑制; 治疗受抑制吲哚胺-2,3-双加氧酶酶活性的医学病症; 提高抗癌治疗的有效性，包括施用抗癌剂; 治疗与癌症有关的肿瘤特异性免疫抑制; 并治疗与感染性疾病相关的免疫抑制。

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