公开(公告)号：US20130213037A1

公开(公告)日：2013-08-22

申请号：US13881319

申请日：2011-10-24

申请人： Isao Kitsukawa ,  Tomohiro Sugano ,  Yoshiyuki Abe ,  Haruyo Kimura ,  Akira Iijima ,  Naoki Ishibashi ,  Syougo Sakashita

发明人： Isao Kitsukawa ,  Tomohiro Sugano ,  Yoshiyuki Abe ,  Haruyo Kimura ,  Akira Iijima ,  Naoki Ishibashi ,  Syougo Sakashita

IPC分类号： F02B37/11

CPC分类号： F02B37/11 ,  F02B37/10 ,  F02B39/10 ,  F02D23/00 ,  F02D41/0007 ,  F02D41/062 ,  F02D2200/702 ,  Y02T10/144

摘要： A turbocharger system for simultaneously improving a fuel efficiency and obtaining a satisfactory hill start performance due to a downsized engine. The system includes an electric assist turbocharger which includes a turbine disposed in an exhaust passage of an engine and driven by exhaust gas, a compressor disposed in an intake passage and driven by a rotational torque of the turbine, and an electric motor assisting a driving force of the compressor and an electric motor control unit which drives the electric motor when detecting a start operation at a sloping road.

摘要翻译： 一种涡轮增压器系统，用于同时提高燃料效率并且由于发动机尺寸减小而获得令人满意的起升性能。 该系统包括电动辅助涡轮增压器，其包括设置在发动机的排气通道中并被排气驱动的涡轮机，设置在进气通道中并由涡轮机的旋转扭矩驱动的压缩机和辅助驱动力的电动机 的压缩机和电动机控制单元，其在检测到在倾斜道路上的起动操作时驱动电动机。

公开(公告)号：US20130213036A1

公开(公告)日：2013-08-22

申请号：US13881309

申请日：2011-10-24

申请人： Isao Kitsukawa ,  Tomohiro Sugano ,  Yoshiyuki Abe ,  Haruyo Kimura ,  Akira Iijima ,  Naoki Ishibashi ,  Syougo Sakashita

发明人： Isao Kitsukawa ,  Tomohiro Sugano ,  Yoshiyuki Abe ,  Haruyo Kimura ,  Akira Iijima ,  Naoki Ishibashi ,  Syougo Sakashita

IPC分类号： F02B37/04

CPC分类号： F02B37/04 ,  F02B37/10 ,  F02B39/10 ,  F02D13/04 ,  F02D23/00 ,  F02D41/0005 ,  F02D41/0007 ,  F02D2200/602 ,  F02M26/05 ,  F02M26/10 ,  F02M26/28 ,  Y02T10/144 ,  Y02T10/42

摘要： An engine system for ensuring a sufficient boost pressure during engine braking and improving a braking force of a compression release brake. The system includes: a compression release brake device that operates a compression release brake to obtain a braking force during engine braking by forcibly opening an exhaust valve and releasing a compressive pressure near a compression top dead center of an engine; a power-assisted turbocharger including a turbine disposed on an exhaust passage of the engine and driven by exhaust, a compressor disposed on an intake passage and driven by a rotational torque of the turbine, and an electric motor that assists a drive force of the compressor; and an electric motor control unit that drives the electric motor when the compressor release brake is operated.

摘要翻译： 一种用于在发动机制动期间确保足够的增压压力并提高压缩释放制动器的制动力的发动机系统。 该系统包括：压缩释放制动装置，其通过强制地打开排气门并释放发动机的压缩上止点附近的压缩压力来操作压缩释放制动器以获得发动机制动期间的制动力; 动力辅助涡轮增压器，其包括设置在发动机的排气通道上并由排气驱动的涡轮机，设置在进气通道上并由涡轮机的旋转扭矩驱动的压缩机以及辅助压缩机的驱动力的电动机 ; 以及当压缩机释放制动器被操作时驱动电动机的电动机控制单元。

公开(公告)号：US20130209291A1

公开(公告)日：2013-08-15

申请号：US13882079

申请日：2011-10-26

申请人： Isao Kitsukawa ,  Tomohiro Sugano ,  Yoshiyuki Abe ,  Haruyo Kimura ,  Akira Iijima ,  Naoki Ishibashi ,  Syougo Sakashita

发明人： Isao Kitsukawa ,  Tomohiro Sugano ,  Yoshiyuki Abe ,  Haruyo Kimura ,  Akira Iijima ,  Naoki Ishibashi ,  Syougo Sakashita

IPC分类号： F04D13/06

CPC分类号： F04D13/06 ,  F02B37/004 ,  F02B37/013 ,  F02B37/10 ,  F02B37/16 ,  F02B37/18 ,  F02B39/10 ,  F02D23/00 ,  Y02T10/144

摘要： A turbocharger system includes: a high-pressure stage turbocharger including a high-pressure stage turbine disposed on an exhaust passage and driven by exhaust, and a high-pressure stage compressor disposed on an intake passage and driven by a rotational torque of the high-pressure stage turbine; and a low-pressure stage turbocharger including a low-pressure stage turbine disposed on the exhaust passage of a more downstream side than the high-pressure stage turbine and driven by exhaust, and a low-pressure stage compressor disposed on the intake passage of a more upstream side than the high-pressure stage compressor and driven by a rotational torque of the low-pressure stage turbine, wherein the high-pressure stage turbocharger includes an electric motor that assists a drive force of the high-pressure stage compressor.

摘要翻译： 涡轮增压器系统包括：高压级涡轮增压器，包括设置在排气通道上并被排气驱动的高压级涡轮机;以及高压级压缩机，其设置在进气通道上并由高压级涡轮机的旋转扭矩驱动， 压力级涡轮; 以及低压级涡轮增压器，其包括设置在比高压级涡轮机更靠下游侧的排气通道上并由排气驱动的低压级涡轮机，以及设置在排气通道的进气通道上的低压级压缩机 比高压级压缩机更上游侧由低压级涡轮机的旋转扭矩驱动，其中高压级涡轮增压器包括辅助高压级压缩机的驱动力的电动机。

公开(公告)号：US07557127B2

公开(公告)日：2009-07-07

申请号：US12264363

申请日：2008-11-04

申请人： Naoki Ishibashi ,  Yuki Sawada ,  Yasuharu Urano ,  Shigeki Satoh ,  Yoshikazu Inoue ,  Yoshiteru Eikyu ,  Koichiro Mukoyoshi ,  Kazunori Kamijo ,  Fumiyuki Shirai ,  Hisashi Takasugi

发明人： Naoki Ishibashi ,  Yuki Sawada ,  Yasuharu Urano ,  Shigeki Satoh ,  Yoshikazu Inoue ,  Yoshiteru Eikyu ,  Koichiro Mukoyoshi ,  Kazunori Kamijo ,  Fumiyuki Shirai ,  Hisashi Takasugi

IPC分类号： C07D401/12 ,  C07D403/12 ,  A61K31/497 ,  A61K31/506 ,  A61K31/501

CPC分类号： C07D213/74 ,  C07C259/06 ,  C07D207/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14

摘要： Compounds having the formula (I): wherein R1 is hydrogen, lower alkyl, lower alkenyl, lower or higher alkynyl, cyclo(lower)alkyl, cyclo(higher)alkyl, cyclo(lower)alkyl(lower)alkyl, cyclo(higher)alkyl(lower)alkyl, cyclo(lower)alkenyl(lower)alkyl, aryl-fused cyclo(lower)alkyl, lower alkoxy, acyl, aryl, ar(lower)alkoxy, ar(lower)alkyl, heteroar(lower)alkyl, amino, heteroaryl, heterocyclyl or heterocyclyl(lower)alkyl, which may be substituted with one or more suitable substituent(s), R2 is hydrogen or lower alkyl, X is pyrrolidinylene or piperidinylene, Y is pyridylene, which may be substituted with one or more suitable substituent(s), Z is lower alkenylene, which may be substituted with lower alkyl or halogen, and salts thereof are useful as a histone deacetylase inhibitors.

摘要翻译： 具有式（I）的化合物：其中R1是氢，低级烷基，低级烯基，低级或高级炔基，环（低级）烷基，环（高级）烷基，环（低级）烷基（低级）烷基， 烷基，低级烷基，低级烷基，低级烷基，低级烷基，低级烷基，低级烷基，低级烷基， 氨基，杂芳基，杂环基或杂环基（低级）烷基，其可以被一个或多个合适的取代基取代，R 2是氢或低级烷基，X是吡咯烷基或哌啶子基，Y是亚吡啶基，其可以被一个或多个 更合适的取代基，Z是低级亚烯基，其可以被低级烷基或卤素取代，其盐可用作组蛋白脱乙酰酶抑制剂。

公开(公告)号：US07249883B2

公开(公告)日：2007-07-31

申请号：US11224035

申请日：2005-09-13

申请人： Masao Kuroda ,  Naoki Ishibashi ,  Yutaka Kobayashi

发明人： Masao Kuroda ,  Naoki Ishibashi ,  Yutaka Kobayashi

IPC分类号： G01K7/00

CPC分类号： G01K1/165 ,  G01K7/427 ,  G01K13/002

摘要： A deep-area temperature calculating device 441 calculates the temperature Tcore of a deep area on the basis of a first body-surface temperature and second body-surface temperature from body-surface sensors 31A and 31B, and on the basis of a first intermediate temperature and second intermediate temperature from intermediate sensors 32A and 32B. Since the temperature Tcore of the deep area is determined from two body-surface temperatures and two intermediate temperatures, the temperature Tcore of the deep area can be calculated regardless of the heat resistance of the thermometer without making any assumptions regarding the heat resistance of the area that extends from the deep area of the human body to the body surface. Thereby, the temperature Tcore of the deep area can be calculated and the body temperature can be measured with high precision regardless of differences in the body type or contact with clothing or bedding.

摘要翻译： 深区域温度计算装置441基于身体表面传感器31A和31B的第一体表温度和第二体表温度计算深区域的温度T N“ ，并且基于来自中间传感器32A和32B的第一中间温度和第二中间温度。由于深部区域的温度T 从两个体表温度确定，并且两个中间体 可以不考虑温度计的耐热性而不考虑从人体的深部区域延伸的区域的耐热性的假设来计算深度区域的温度T _{身体表面。 因此，可以计算深部区域的温度T core，并且可以高精度地测量体温，而不管身体类型的差异或与衣物或床上用品的接触。}

公开(公告)号：US07129243B2

公开(公告)日：2006-10-31

申请号：US10250444

申请日：2001-12-18

申请人： Ichiro Shima ,  Takehiko Ohkawa ,  Kentaro Sato ,  Naoki Ishibashi ,  Kenichiro Imamura

发明人： Ichiro Shima ,  Takehiko Ohkawa ,  Kentaro Sato ,  Naoki Ishibashi ,  Kenichiro Imamura

IPC分类号： A61K31/50

CPC分类号： C07K5/06139 ,  A61K38/00 ,  C07K5/06191

摘要： The present invention relates to a compound of the formula (I) wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts thereof. The compound (1) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases in human being and animals

摘要翻译： 本发明涉及式（I）化合物，其中R 1为被卤素取代的苯并呋喃基或被卤素取代的苯乙烯基; R2是取代的羟基，取代的巯基或取代的磺酰基; X是其药学上可接受的盐。 本发明化合物（1）及其药学上可接受的盐对一氧化氮（NO）的产生具有很强的抑制活性，可用于预防和/或治疗人和动物中NO介导的疾病

公开(公告)号：US09790850B2

公开(公告)日：2017-10-17

申请号：US13881319

申请日：2011-10-24

申请人： Isao Kitsukawa ,  Tomohiro Sugano ,  Yoshiyuki Abe ,  Haruyo Kimura ,  Akira Iijima ,  Naoki Ishibashi ,  Syougo Sakashita

发明人： Isao Kitsukawa ,  Tomohiro Sugano ,  Yoshiyuki Abe ,  Haruyo Kimura ,  Akira Iijima ,  Naoki Ishibashi ,  Syougo Sakashita

IPC分类号： F02B33/44 ,  F02B37/11 ,  F02B37/10 ,  F02B39/10 ,  F02D23/00

CPC分类号： F02B37/11 ,  F02B37/10 ,  F02B39/10 ,  F02D23/00 ,  F02D41/0007 ,  F02D41/062 ,  F02D2200/702 ,  Y02T10/144

摘要： A turbocharger system for simultaneously improving a fuel efficiency and obtaining a satisfactory hill start performance due to a downsized engine. The system includes an electric assist turbocharger which includes a turbine disposed in an exhaust passage of an engine and driven by exhaust gas, a compressor disposed in an intake passage and driven by a rotational torque of the turbine, and an electric motor assisting a driving force of the compressor and an electric motor control unit which drives the electric motor when detecting a start operation at a sloping road.

公开(公告)号：US09512843B2

公开(公告)日：2016-12-06

申请号：US13882065

申请日：2011-10-26

申请人： Isao Kitsukawa ,  Tomohiro Sugano ,  Yoshiyuki Abe ,  Haruyo Kimura ,  Akira Iijima ,  Naoki Ishibashi ,  Syougo Sakashita

发明人： Isao Kitsukawa ,  Tomohiro Sugano ,  Yoshiyuki Abe ,  Haruyo Kimura ,  Akira Iijima ,  Naoki Ishibashi ,  Syougo Sakashita

IPC分类号： F02B33/44 ,  F04D13/06 ,  F02B37/10 ,  F02B39/10 ,  F02D23/00

CPC分类号： F04D13/06 ,  F02B37/10 ,  F02B37/14 ,  F02B39/10 ,  F02D23/00 ,  F02D41/0007 ,  F02D2200/50 ,  F02M26/05 ,  F02M26/23 ,  Y02T10/121 ,  Y02T10/144

摘要： A turbocharger system for achieving both improvement of fuel efficiency by engine downsizing and excellent shock loading resistance. The system includes: a power-assisted turbocharger mounted on a vehicle having an accessory and including a turbine disposed on an exhaust passage of an engine and driven by exhaust, a compressor disposed on an intake passage and driven by a rotational torque of the turbine, and an electric motor that assists a drive force of the compressor; and an electric motor control unit that drives the electric motor when the accessory is being driven.

摘要翻译： 一种涡轮增压器系统，用于通过发动机小型化和优异的抗冲击负载能力来实现燃料效率的提高。 该系统包括：安装在具有附件并且包括设置在发动机的排气通道上并由排气驱动的涡轮机的车辆上的动力辅助涡轮增压器，设置在进气通道上并由涡轮的旋转扭矩驱动的压缩机， 以及辅助压缩机的驱动力的电动机; 以及当所述附件被驱动时驱动所述电动机的电动机控制单元。

公开(公告)号：US09334833B2

公开(公告)日：2016-05-10

申请号：US13881103

申请日：2011-10-24

申请人： Isao Kitsukawa ,  Tomohiro Sugano ,  Yoshiyuki Abe ,  Haruyo Kimura ,  Akira Iijima ,  Naoki Ishibashi ,  Syougo Sakashita

发明人： Isao Kitsukawa ,  Tomohiro Sugano ,  Yoshiyuki Abe ,  Haruyo Kimura ,  Akira Iijima ,  Naoki Ishibashi ,  Syougo Sakashita

IPC分类号： F02B33/44 ,  F02M25/07 ,  F02B37/013 ,  F02B37/10 ,  F02B39/10 ,  F02D21/08 ,  F02D23/00 ,  F02B37/00

CPC分类号： F02M26/03 ,  F02B37/004 ,  F02B37/013 ,  F02B37/10 ,  F02B39/10 ,  F02D21/08 ,  F02D23/00 ,  Y02T10/144

摘要： A turbocharger system for ensuring a sufficient exhaust gas recirculation (“EGR”) amount in all operating conditions, and reducing NOx emission from an engine. The system includes an EGR controller that re-circulates a part of exhaust gas discharged from the engine to an intake side. The turbocharger is a power-assisted turbocharger including an electric motor that assists a drive force of a compressor. The EGR controller controls an amount of exhaust gas recirculated to the intake side so as to inhibit the generation of NOx regardless of an amount of oxygen necessary for combustion of the engine. An electric motor control unit drives the electric motor, by the control of the EGR controller, when the amount of oxygen necessary for the combustion of the engine is deficient.

摘要翻译： 一种涡轮增压器系统，用于确保在所有操作条件下足够的废气再循环（“EGR”）量，并且减少来自发动机的NOx排放。 该系统包括EGR控制器，其将从发动机排出的废气的一部分重新循环到进气侧。 涡轮增压器是一种动力辅助涡轮增压器，其包括有助于压缩机的驱动力的电动机。 EGR控制器控制再循环到进气侧的废气量，以便与发动机燃烧所需的氧气量无关地抑制NOx的产生。 当发动机燃烧所需的氧气量不足时，电动机控制单元通过EGR控制器的控制来驱动电动机。

公开(公告)号：US08367702B2

公开(公告)日：2013-02-05

申请号：US12680301

申请日：2008-09-25

申请人： Kenichi Onda ,  Kenichiro Imamura ,  Fumie Sato ,  Hiroyuki Moritomo ,  Yasuharu Urano ,  Yuki Sawada ,  Naoki Ishibashi ,  Keita Nakanishi ,  Kazuhiro Yokoyama ,  Shigetada Furukawa ,  Kazuhiro Momose

发明人： Kenichi Onda ,  Kenichiro Imamura ,  Fumie Sato ,  Hiroyuki Moritomo ,  Yasuharu Urano ,  Yuki Sawada ,  Naoki Ishibashi ,  Keita Nakanishi ,  Kazuhiro Yokoyama ,  Shigetada Furukawa ,  Kazuhiro Momose

IPC分类号： A61K31/04 ,  C07D215/38

CPC分类号： C07D401/12 ,  C07D215/233 ,  C07D401/06 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/107

摘要： As a result of extensive studies on NAD(P)H oxidase inhibitors, the present inventors found that a quinolone derivative having, at the 2-position, an alkyl group substituted with a heteroatom or the like has an excellent NAD(P)H oxidase inhibitory activity, and accomplished the present invention. The compound of the present invention has a reactive oxygen species production inhibitory activity based on the NAD(P)H oxidase inhibitory activity, and therefore can be used as an agent for preventing and/or treating diabetes, impaired glucose tolerance, hyperlipidemia, fatty liver, diabetic complications and the like.

摘要翻译： 作为对NAD（P）H氧化酶抑制剂的广泛研究的结果，本发明人发现，在2位具有被杂原子等取代的烷基的喹诺酮衍生物具有优异的NAD（P）H氧化酶 抑制活性，完成了本发明。 本发明的化合物具有基于NAD（P）H氧化酶抑制活性的活性氧产生抑制活性，因此可用作糖尿病预防和/或治疗药物，糖耐量异常，高脂血症，脂肪肝 ，糖尿病并发症等。