公开(公告)号：US20110165190A1

公开(公告)日：2011-07-07

申请号：US12833633

申请日：2010-07-09

申请人： David Ian Watkins ,  Nancy Ann Wilson Schlei

发明人： David Ian Watkins ,  Nancy Ann Wilson Schlei

IPC分类号： A61K39/21 ,  A61P37/04 ,  A61P31/18

CPC分类号： A61K39/00 ,  C12N2740/16034

摘要： Disclosed are compositions, kits, and methods related to HIV vaccines and immunogenic compositions. Typically, the compositions include a mixture of individual and separate DNA polynucleotides that encode different HIV polypeptides or fragments thereof. The mixture of polynucleotides is designed to elicit a broad immunogenic response which may be subsequently boosted by administering a second composition such as a recombinant virus vector composition. The compositions, kits, and methods may be utilized for treating or preventing HIV infection or disease.

摘要翻译： 公开了与HIV疫苗和免疫原性组合物相关的组合物，试剂盒和方法。 通常，组合物包括编码不同HIV多肽或其片段的个体和单独的DNA多核苷酸的混合物。 设计多核苷酸的混合物以引发广泛的免疫原性应答，其可以随后通过施用第二组合物如重组病毒载体组合物来增强。 组合物，试剂盒和方法可用于治疗或预防HIV感染或疾病。