公开(公告)号：US08318802B2

公开(公告)日：2012-11-27

申请号：US12278061

申请日：2007-02-02

申请人： Naglesh R. Palepu

发明人： Naglesh R. Palepu

IPC分类号： A01N43/08 ,  A61K31/34

CPC分类号： A61K9/19 ,  A61K9/0019 ,  A61K31/557 ,  A61K31/5585 ,  A61K47/183 ,  A61K47/26

摘要： This invention relates to a stable epoprostenol composition that can be combined with commercially available IV fluids and can be administered in its reconstituted and/or diluted form under ambient conditions of about 15-30° C. for greater than 24 hours. The composition preferably contains (a) epoprostenol or a salt thereof; (b) a alkalinization agent; and (c) a base, such that when reconstituted or in solution, the solution has a pH>11. Methods for making the lyophilized composition are also disclosed.

摘要翻译： 本发明涉及一种稳定的前荚MP素组合物，其可与市售IV液体组合，并且可以在约15-30℃的环境条件下以其重构和/或稀释形式施用大于24小时。 组合物优选含有（a）依前列醇或其盐; （b）碱化剂; 和（c）碱，使得当重构或溶解时，溶液的pH> 11。 还公开了制备冻干组合物的方法。