公开(公告)号：US20240299448A1

公开(公告)日：2024-09-12

申请号：US18181865

申请日：2023-03-10

Applicant: Luda DIATCHENKO ,  Jeffrey MOGIL ,  Lucas Vasconcelos LIMA ,  Marc PARISIEN ,  Massimo ALLEGRI ,  Nader GHASEMLOU ,  Mohamad KARAKY

Inventor： Luda DIATCHENKO ,  Jeffrey MOGIL ,  Lucas Vasconcelos LIMA ,  Marc PARISIEN ,  Massimo ALLEGRI ,  Nader GHASEMLOU ,  Mohamad KARAKY

IPC: A61K35/15 ,  A61K31/197 ,  A61K31/485 ,  A61K31/56 ,  A61K38/18 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21 ,  A61P25/04

CPC classification number: A61K35/15 ,  A61K31/197 ,  A61K31/485 ,  A61K31/56 ,  A61K38/1866 ,  A61K38/191 ,  A61K38/2006 ,  A61K38/204 ,  A61K38/2053 ,  A61K38/208 ,  A61K38/21 ,  A61P25/04

Abstract: The present invention relates to a method of preventing or treating chronic pain comprising administering to a subject, in an amount/number effective to elicit, sustain or potentiate an inflammatory process, a pro-inflammatory compound, myeloid leukocyte cells or a substance that increases the number or activity of myeloid leukocyte cells.

公开(公告)号：US20140220004A1

公开(公告)日：2014-08-07

申请号：US14122812

申请日：2012-06-01

Applicant: Nader Ghasemlou ,  Christian A. Von Hehn ,  Clifford J. Woolf

Inventor： Nader Ghasemlou ,  Christian A. Von Hehn ,  Clifford J. Woolf

IPC: A61K39/395 ,  A61K31/713 ,  A61K45/06 ,  C07K16/18 ,  C07K14/47

CPC classification number: A61K39/3955 ,  A61K31/713 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18

Abstract: Provided herein are compositions containing an antibody or antigen-binding antibody fragment that specifically binds to metallothionein 2 (MT2) protein, and compositions containing an agent that binds to or neutralizes a function of MT2 protein and/or an oligonucleotide that decreases the expression of MT2 mRNA in a mammalian cell, and optionally, one or more anti-inflammatory agents and/or analgesics. Also provided are methods of decreasing pain in a mammal that include administering to the mammal an agent that binds to or neutralizes a function of MT2 protein and/or an oligonucleotide that decreases the expression of MT2 mRNA in a mammalian cell, in an amount sufficient to decrease the level of extracellular MT2 protein or neutralize a function of extracellular MT2 protein in the mammal, thereby decreasing pain in the mammal.

Abstract translation: 本文提供含有特异性结合金属硫蛋白2（MT2）蛋白的抗体或抗原结合抗体片段的组合物，以及含有与MT2蛋白结合或中和的功能的组合物和/或降低MT2表达的寡核苷酸 mRNA，以及任选的一种或多种抗炎剂和/或镇痛药。 还提供了减少哺乳动物疼痛的方法，其包括向哺乳动物施用结合或中和MT2蛋白和/或降低哺乳动物细胞中MT2 mRNA表达的寡核苷酸的功能的试剂，其量足以 降低细胞外MT2蛋白的水平或中和哺乳动物细胞外MT2蛋白的功能，从而降低哺乳动物的疼痛。