公开(公告)号：US20250049825A1

公开(公告)日：2025-02-13

申请号：US18442980

申请日：2024-02-15

Applicant: National Jewish Health

Inventor： Dennis R. Voelker ,  Mari Numata-Nakamura

IPC: A61K31/683 ,  A61K9/00 ,  A61K9/127 ,  A61K31/66

Abstract: The invention generally relates to methods to inhibit inflammation or pathogen infection by administering at least one anionic lipid or compositions comprising at least one anionic lipid to an individual. The invention also relates to methods to prevent or inhibit respiratory syncytial virus (RSV) infection by administering at least one anionic lipid or compositions comprising at least one anionic lipid to an individual. The invention further relates to compositions comprising randomly mixed surfactant lipids and methods to produce the compositions.

公开(公告)号：US20250035617A1

公开(公告)日：2025-01-30

申请号：US18911597

申请日：2024-10-10

Applicant: National Jewish Health

Inventor： Milene Saavedra

IPC: G01N33/537 ,  C12Q1/6883 ,  G01N33/68 ,  G16B40/00 ,  G16B40/30 ,  G16C99/00 ,  G16H50/30

Abstract: The present invention is related to novel methods for categorizing and treating a population of subjects that are at risk for increased pulmonary exacerbation and disease progression.

公开(公告)号：US20250003969A1

公开(公告)日：2025-01-02

申请号：US18883270

申请日：2024-09-12

Applicant: National Jewish Health

Inventor： Donald Y.M. Leung ,  Elena Goleva ,  Lingbo Li

IPC: G01N33/573 ,  C07K16/40 ,  C12N15/113 ,  C12Q1/48

Abstract: The present invention is directed toward novel methods to identify as well as to treat a subject having an inflammatory disease resistant to corticosteroids.

公开(公告)号：US12117446B2

公开(公告)日：2024-10-15

申请号：US17529700

申请日：2021-11-18

Applicant: National Jewish Health

Inventor： Donald Y. M. Leung ,  Elena Goleva ,  Lingbo Li

IPC: G01N33/00 ,  C07K16/40 ,  C12N15/113 ,  C12Q1/48 ,  G01N33/573

CPC classification number: G01N33/573 ,  C07K16/40 ,  C12N15/1137 ,  C12Q1/485 ,  C07K2317/76 ,  C12N2310/14 ,  C12N2320/30 ,  G01N2333/91205 ,  G01N2333/91215 ,  G01N2800/122 ,  G01N2800/52 ,  G01N2800/7095

Abstract: The present invention is directed toward novel methods to identify as well as to treat a subject having an inflammatory disease resistant to corticosteroids.

公开(公告)号：US20240327862A1

公开(公告)日：2024-10-03

申请号：US18605149

申请日：2024-03-14

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE ,  NATIONAL JEWISH HEALTH

Inventor： Brian Freed ,  Kirsten Anderson ,  Christina Roark ,  Jennifer Matsuda

IPC: C12N15/85 ,  A01K67/0275 ,  A61K35/28 ,  A61K48/00 ,  C12N5/0789 ,  C12N9/22 ,  C12N15/11

CPC classification number: C12N15/85 ,  A01K67/0275 ,  A61K35/28 ,  C12N5/0647 ,  C12N9/22 ,  C12N15/11 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0325 ,  A61K48/00 ,  C12N2310/20 ,  C12N2740/15042 ,  C12N2750/14142 ,  C12N2800/80

Abstract: Methods of preventing or treating rheumatoid arthritis (RA) in a subject by introducing the DRB1*04:01K71E mutation that is resistant to RA. The resistant allele is introduced into the subject having or at risk of developing RA, using a HLA CRISPR/Cas9 vector that targets codon 71 in the HLA allele DRB1*04:01, introducing a single A to G point mutation in codon 71 by homology directed repair to alter the lysine at position 71 of the expressed protein to glutamic acid. This modified allele is affected in the subject's hematopoietic stem cells, which are then expanded and transplanted back into the patient. This microgene therapy confers RA-resistance via an autologous transplant. The invention includes isolated nucleic acids, vectors, recombinant viruses, cells, and pharmaceutical compositions to modify the HLA DRB1*04:01 allele.

公开(公告)号：US11986450B2

公开(公告)日：2024-05-21

申请号：US17735368

申请日：2022-05-03

Applicant: National Jewish Health

Inventor： Brian J. Day ,  Preston E. Bratcher

IPC: A61K31/21 ,  A61K45/06 ,  A61P11/00 ,  A61P31/04

CPC classification number: A61K31/21 ,  A61K45/06 ,  A61P11/00 ,  A61P31/04

Abstract: The present invention generally relates to methods and compositions for treating pulmonary infections and inflammation with a composition comprising selenocyanate, hyposelenocyanite or a selenocyanate conjugate.

公开(公告)号：US11937937B2

公开(公告)日：2024-03-26

申请号：US16654333

申请日：2019-10-16

Applicant: National Jewish Health

Inventor： Donald Leung ,  Elena Goleva ,  Evgeny Berdyshev

IPC: A61B5/00

CPC classification number: A61B5/443

Abstract: The invention relates to skin tape stripping methods to identify a subject at risk of having atopic dermatitis, or a subject having atopic dermatitis who is at risk of developing a food allergy, or a subject at risk of developing a food allergy in the absence of the subject having atopic dermatitis.

公开(公告)号：US11922626B2

公开(公告)日：2024-03-05

申请号：US17950376

申请日：2022-09-22

Applicant: National Jewish Health

Inventor： David A. Lynch ,  Stephen M. Humphries

IPC: G06T7/00 ,  A61B5/00 ,  A61B5/055 ,  A61B6/00 ,  G06N5/022 ,  G06N20/10 ,  G16B40/20 ,  G16B40/30 ,  G16B50/30 ,  G16B99/00 ,  G16H30/40 ,  G16H50/20 ,  A61B6/03

CPC classification number: G06T7/0012 ,  A61B5/0062 ,  A61B5/055 ,  A61B6/5217 ,  G06N5/022 ,  G06N20/10 ,  G16B40/20 ,  G16B40/30 ,  G16B50/30 ,  G16B99/00 ,  G16H30/40 ,  G16H50/20 ,  A61B6/03

Abstract: Methods, devices, and systems are provided for quantifying an extent of various pathology patterns in scanned subject images. The detection and quantification of pathology is performed automatically and unsupervised via a trained system. The methods, devices, and systems described herein generate unique dictionaries of elements based on actual image data scans to automatically identify pathology of new image data scans of subjects. The automatic detection and quantification system can detect a number of pathologies including a usual interstitial pneumonia pattern on computed tomography images, which is subject to high inter-observer variation, in the diagnosis of idiopathic pulmonary fibrosis.

公开(公告)号：US20230138022A1

公开(公告)日：2023-05-04

申请号：US17915729

申请日：2021-04-01

Applicant: NATIONAL JEWISH HEALTH

Inventor： Max A. SEIBOLD ,  Yingchun LI

IPC: C12N5/074 ,  C12N5/071 ,  C12N15/90

Abstract: Disclosed herein are methods to reliably and robustly generate a pure population of airway basal cells that are capable of producing a normal mucociliary epithelium. Such basal cells may be used to treat chronic respiratory diseases, such as cystic fibrosis, chronic obstructive pulmonary disease, and asthma.

公开(公告)号：US20230038166A1

公开(公告)日：2023-02-09

申请号：US17778355

申请日：2020-12-17

Applicant: NATIONAL JEWISH HEALTH ,  COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Jerry Allan NICK ,  Delphi CHATTERJEE

IPC: G01N33/569 ,  G01N33/92

Abstract: Methods for detecting a mycobacterial infection in a patient are disclosed. These methods include the step of detecting lipoarabinomannan (LAM) and/or derivatives thereof in a biological sample from the patient. Methods for diagnosing disease, including nontuberculous mycobacterial infection (NTM), and kits for the described methods are also provided.