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公开(公告)号：US20240352542A1
公开(公告)日：2024-10-24
申请号：US18628273
申请日：2024-04-05
发明人： Julien Wist , Samuele Sala , Philipp Nitschke , Jeremy K. Nicholson , Elaine Holmes , Christoph Trautwein , Claire Cannet
IPC分类号： C12Q1/70 , C12Q1/6872 , C12Q1/6876
CPC分类号： C12Q1/70 , C12Q1/6872 , C12Q1/6876
摘要： The invention relates to the field of viral diagnosis. In particular, it is directed to a method for diagnosing a viral infection or a disease associated therewith in a subject comprising the steps of: (a) determining in a sample of said subject the amount of at least one biomarker selected from the group of 3′(,5′-di)deoxy-3′,4′-didehydro furanose derivatives of formula (I) with the exception of 3′-deoxy-3′,4′-didehydro-cytidine (ddhC); and (b) comparing the amount(s) of the at least one biomarkers determined in (a) with a reference, thereby diagnosing a viral infection.
Further, the invention is directed to a method for diagnosing a viral infection or a disease associated therewith in a subject comprising the steps of: (A) determining in a sample of said subject the amount of 3′-deoxy-3′,4′-didehydro-cytidine (ddhC); and (B) comparing the amount of the ddhC determined in (A) with a reference, thereby diagnosing a viral infection; wherein the determination in (a) is done by NMR spectroscopy and the sample of the subject is a urine sample of said subject.
The invention is also related to a diagnostic means for use in diagnosing a viral infection or a disease associated therewith, said diagnostic means comprising at least one biomarker selected from the group of 3′(,5′-di)deoxy-3′,4′-didehydro furanose derivatives of formula (I) with the exception of 3′-deoxy-3′,4′-didehydro-cytidine (ddhC), but also to a diagnostic means comprising 3′-deoxy-3′,4′-didehydro-cytidine (ddhC) for use in diagnosing a viral infection or a disease associated therewith, wherein the amount of the biomarker is determined done by NMR spectroscopy in a urine sample of a subject.
Furthermore, the invention is directed to a device for diagnosing a viral infection or a disease associated therewith in a sample of a subject and to a kit for identifying a subject suffering from a viral infection or a disease associated therewith.-
公开(公告)号：US11786611B2
公开(公告)日：2023-10-17
申请号：US16982704
申请日：2019-05-10
申请人： Murdoch University
发明人： Rakesh Veedu
IPC分类号： A61K48/00 , C12N15/113 , A61K31/7105
CPC分类号： A61K48/0066 , A61K31/7105 , C12N15/1136 , C12N2310/11 , C12N2310/314 , C12N2310/3233 , C12N2320/33 , C12N2320/51
摘要： An isolated or purified antisense oligonucleotide targeted to a nucleic acid molecule encoding vascular endothelial growth factor A (VEGF-A) pre-mRNA, wherein the antisense oligonucleotide has a nucleobase sequence selected from the list comprising SEQ ID NO: 1 to SEQ ID NO: 22 which has a modified backbone structure and sequences with at least 95% sequence identity to SEQ ID NO: 1-22 which have a modified backbone structure, and wherein the antisense oligonucleotide inhibits the expression of human VEGF-A.
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公开(公告)号：US20230081388A1
公开(公告)日：2023-03-16
申请号：US17795828
申请日：2021-01-28
申请人： MURDOCH UNIVERSITY
发明人： Stephen Wilton , May Aung-Htut , Dunhui Li
IPC分类号： C12N15/113 , A61P25/16
摘要： An isolated or purified antisense oligomer with a modified backbone structure for modifying pre-mRNA splicing in the parkin gene transcript or part thereof.
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公开(公告)号：US11459563B2
公开(公告)日：2022-10-04
申请号：US16483329
申请日：2018-02-05
发明人： Stephen Donald Wilton , Sue Fletcher , Archa Fox , Ruohan Li
IPC分类号： C12N15/113 , A61P35/00
摘要： An isolated or purified antisense oligomer for modifying RNA cleavage and processing in the NEAT1 gene transcript or part thereof.
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公开(公告)号：US20210388363A1
公开(公告)日：2021-12-16
申请号：US17411932
申请日：2021-08-25
IPC分类号： C12N15/113
摘要： An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.
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公开(公告)号：US10376536B2
公开(公告)日：2019-08-13
申请号：US15573184
申请日：2016-05-10
申请人： MURDOCH UNIVERSITY
IPC分类号： C12N15/11 , C12N15/113 , A61K31/7105 , A61K48/00
摘要： An antisense oligomer capable of binding to a selected target on the ITGA4 gene transcript to modify pre-mRNA splicing in an ITGA4 gene transcript or part thereof.
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公开(公告)号：US20240141360A1
公开(公告)日：2024-05-02
申请号：US18310289
申请日：2023-05-01
IPC分类号： C12N15/113
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3233 , C12N2310/3513 , C12N2320/30 , C12N2320/33
摘要： An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.
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公开(公告)号：US11479772B2
公开(公告)日：2022-10-25
申请号：US16825918
申请日：2020-03-20
IPC分类号： C12N15/113 , A61P21/00
摘要： Improved compositions and methods for treating a disease or disorder through target exon skipping, and preferably muscular dystrophy by administering antisense thiomorpholino molecules capable of binding to a selected target site in the human dystrophin gene to induce exon skipping to produce a functional Dystrophin protein.
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公开(公告)号：US11441148B2
公开(公告)日：2022-09-13
申请号：US17411932
申请日：2021-08-25
IPC分类号： C12N15/113 , C12Q1/68
摘要： An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.
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公开(公告)号：US11236338B2
公开(公告)日：2022-02-01
申请号：US14917173
申请日：2014-09-05
IPC分类号： C12N15/11 , C12N15/113 , C07F9/6533
摘要： The present disclosure relates to antisense oligomers and related compositions and methods for inducing exon inclusion as a treatment for glycogen storage disease type II (GSD-II) (also known as Pompe disease, glycogenosis II, acid maltase deficiency (AMD), acid alpha-glucosidase deficiency, and lysosomal alpha-glucosidase deficiency), and more specifically relates to inducing inclusion of exon 2 and thereby restoring levels of enzymatically active acid alpha-glucosidase (GAA) protein encoded by the GAA gene.
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