公开(公告)号：US5214170A

公开(公告)日：1993-05-25

申请号：US827151

申请日：1992-01-27

申请人： Miyuki Tanabe ,  Shigeru Ikuta

发明人： Miyuki Tanabe ,  Shigeru Ikuta

IPC分类号： C07C401/00

CPC分类号： C07C401/00 ,  Y02P20/55 ,  Y10T436/173845

摘要： A novel 1.alpha. (or 24R), 25-dihydroxy vitamin D.sub.3 amino acid derivative of the formula ##STR1## wherein R.sub.1 is OH or --O--CO--A--NH.sub.2, and R.sub.2 and R.sub.3 are each selected from the group consisting of hydrogen, OH and --O--CO--A--NH.sub.2 ; wherein one of R.sub.2 and R.sub.3 is hydrogen, one of R.sub., R.sub.2 and R.sub.3 is OH, and one of R.sub.1, R.sub.2 and R.sub.3 is --O--CO--A--NH.sub.2 ; and wherein A is C.sub.1-10 alkylene, is produced by removing a protective group for the amino group, e.g. 9-fluorenylmethyloxycarbonyl, in the presence of a base in an inert solvent. A radioisotope iodine-labeled residue is then attached to the amino group to produce a derivative useful in the assay of 1.alpha. (or 24R), 25-dihydroxy vitamin D.sub.3 in a specimen.

摘要翻译： 其中R 1是OH或-O-CO-A-NH 2的式1α（或24R），25-二羟基维生素D3氨基酸衍生物，其中R 1和R 2各自选自氢 ，OH和-O-CO-A-NH 2; 其中R2和R3中的一个是氢，R，R2和R3之一是OH，R1，R2和R3中的一个是-O-CO-A-NH2; 并且其中A为C 1-10亚烷基，是通过除去氨基的保护基来制备的。 9-芴基甲氧基羰基，在碱的存在下在惰性溶剂中。 然后将放射性同位素碘标记的残基连接到氨基上以产生可用于测定样品中1α（或24R），25-二羟基维生素D3的衍生物。

公开(公告)号：US5117018A

公开(公告)日：1992-05-26

申请号：US417313

申请日：1989-10-05

申请人： Miyuki Tanabe ,  Shigeru Ikuta

发明人： Miyuki Tanabe ,  Shigeru Ikuta

IPC分类号： C07C401/00

CPC分类号： C07C401/00 ,  Y10T436/173845

摘要： A novel 1.alpha. (or 24R), 25-dihydroxy vitamin D.sub.3 amino acid derivative of the formula ##STR1## wherein R.sub.1 is OH or --O--CO--A--NH.sub.2, and R.sub.2 and R.sub.3 are each selected from the group consisting of hydrogen, OH and --O--CO--A--NH.sub.2 ; wherein one of R.sub.2 and R.sub.3 is hydrogen, one of R.sub.1, R.sub.2 and R.sub.3 is OH, and one of R.sub.1, R.sub.2 and R.sub.3 is --O--CO--A--NH.sub.2 ; and wherein A is C.sub.1-10 alkylene, is produced by removing a protective group for the amino group, e.g. 9-fluorenylmethyloxycarbonyl, in the presence of a base in an inert solvent. A radioisotope iodine-labeled residue is then attached to the amino group to produce a derivative useful in the assay of 1.alpha. (or 24R), 25-dihydroxy vitamin D.sub.3 in a specimen.

公开(公告)号：US5202266A

公开(公告)日：1993-04-13

申请号：US733628

申请日：1991-07-22

申请人： Nobuaki Nakagawa ,  Shigeru Ikuta ,  Miyuki Tanabe

发明人： Nobuaki Nakagawa ,  Shigeru Ikuta ,  Miyuki Tanabe

IPC分类号： C07C401/00 ,  G01N33/82

CPC分类号： C07C401/00 ,  G01N33/82 ,  Y02P20/55 ,  Y10S436/815

摘要： A novel 25-hydroxy vitamin D.sub.3 amino acid derivative of the formula ##STR1## wherein R.sub.1 is C.sub.1-10 alkylene, is produced by removing a protective group for the amino group, e.g. 9-fluorenylmethyloxycarbonyl, in the presence of a base in an inert solvent. A radioisotope iodine-labeled residue is then attached to the amino group to produce a derivative useful in the assay of 25-hydroxy vitamin D.sub.3 in a specimen.

摘要翻译： 通过除去氨基的保护基，例如，通过除去氨基的保护基来制备式“IMAGE”的新型25-羟基维生素D3氨基酸衍生物，其中R 1是C 1-10亚烷基。 9-芴基甲氧基羰基，在碱的存在下在惰性溶剂中。 然后将放射性同位素碘标记的残基连接到氨基上以产生可用于样品中的25-羟基维生素D3的测定中的衍生物。

公开(公告)号：US5075465A

公开(公告)日：1991-12-24

申请号：US258017

申请日：1988-10-14

申请人： Nobuaki Nakagawa ,  Shigeru Ikuta ,  Miyuki Tanabe

发明人： Nobuaki Nakagawa ,  Shigeru Ikuta ,  Miyuki Tanabe

IPC分类号： G01N33/53 ,  C07C67/00 ,  C07C401/00 ,  G01N33/82

CPC分类号： G01N33/82 ,  C07C401/00 ,  Y02P20/55

摘要： A novel 25-hydroxy vitamin D.sub.3 amino acid derivative of the formula ##STR1## wherein R.sub.1 is C.sub.1-10 alkylene, is produced by removing a protective group for the amino group, e.g. 9-fluorenylmethyl-oxycarbonyl, in the presence of a base in an inert solvent. A radioisotope iodine-labeled residue is then attached to the amino group to produce a derivative useful in the assay of 25-hydroxy vitamin D.sub.3 in a specimen.