公开(公告)号：US08962880B2

公开(公告)日：2015-02-24

申请号：US14006198

申请日：2012-03-21

Applicant: Guobin Ren ,  Ying Liu ,  Jinyao Chen ,  Xiaoling Huang ,  Lin Xiao ,  Li Cai ,  Zhen Zhang ,  Xuejun Wu ,  Haiyan Sun ,  Quanhai Liu ,  Liling Jin ,  Minyu Liu ,  Yifang Deng ,  Zhiru Xu ,  Renhai Chen ,  Chungang Li ,  Xiangduan Tan ,  Yan Qin

Inventor： Guobin Ren ,  Ying Liu ,  Jinyao Chen ,  Xiaoling Huang ,  Lin Xiao ,  Li Cai ,  Zhen Zhang ,  Xuejun Wu ,  Haiyan Sun ,  Quanhai Liu ,  Liling Jin ,  Minyu Liu ,  Yifang Deng ,  Zhiru Xu ,  Renhai Chen ,  Chungang Li ,  Xiangduan Tan ,  Yan Qin

IPC: C07C227/14 ,  C07C215/10 ,  C07C229/38 ,  C07J63/00

CPC classification number: C07C227/14 ,  C07C215/10 ,  C07C229/38 ,  C07J63/008

Abstract: An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.

Abstract translation: 一种无定形亚洲氨丁三醇盐及其制备方法。 该方法包括以下步骤：（1）将积雪草酸溶解在有机溶剂中; 步骤（2）与氨丁三醇混合; 步骤（3）搅拌并使其成盐，然后除去有机溶剂。 无定形亚洲氨基丁三醇盐的制备方法容易有效，与现有技术相比，所得到的亚稳氨基甲基胺盐的水溶性和生物利用度大大降低。

公开(公告)号：US20140128463A1

公开(公告)日：2014-05-08

申请号：US14129000

申请日：2012-06-25

Applicant: Zhenpeng Yu ,  Gouping Wang ,  Zhen Zhang ,  Minyu Liu ,  Xiaoling Huang ,  Ying Liu ,  Lin Xiao ,  Li Cai ,  Xuejun Wu ,  Yifang Deng ,  Mianli Pan ,  Renhai Chen ,  Shenrong Tang ,  Quanhai Liu

Inventor： Zhenpeng Yu ,  Gouping Wang ,  Zhen Zhang ,  Minyu Liu ,  Xiaoling Huang ,  Ying Liu ,  Lin Xiao ,  Li Cai ,  Xuejun Wu ,  Yifang Deng ,  Mianli Pan ,  Renhai Chen ,  Shenrong Tang ,  Quanhai Liu

IPC: C07C235/84 ,  C07C231/02

CPC classification number: C07C235/84 ,  A61K31/165 ,  A61K31/166 ,  A61K31/222 ,  C07C231/02 ,  C07C235/20 ,  C07C235/26 ,  C07C251/24 ,  C07C325/02 ,  C07C2601/02 ,  C07C2601/14

Abstract: Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.

Abstract translation: 公开了酰胺化合物，其制备方法和用途，具体地，由式I表示的化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，Q，X和n如描述中所定义。 还公开了制备式I化合物的方法，含有该化合物的组合物及其在制备用于调节血脂和/或预防胆结石的药物中的用途。 本发明公开的式I化合物在体外具有稳定性，在药用有机溶剂中的溶解性好，动物中具有良好的生物利用度。

公开(公告)号：US10428013B2

公开(公告)日：2019-10-01

申请号：US14129000

申请日：2012-06-25

Applicant: Zhenpeng Yu ,  Gouping Wang ,  Zhen Zhang ,  Minyu Liu ,  Xiaoling Huang ,  Ying Liu ,  Lin Xiao ,  Li Cai ,  Xuejun Wu ,  Yifang Deng ,  Mianli Pan ,  Renhai Chen ,  Shenrong Tang ,  Quanhai Liu

Inventor： Zhenpeng Yu ,  Gouping Wang ,  Zhen Zhang ,  Minyu Liu ,  Xiaoling Huang ,  Ying Liu ,  Lin Xiao ,  Li Cai ,  Xuejun Wu ,  Yifang Deng ,  Mianli Pan ,  Renhai Chen ,  Shenrong Tang ,  Quanhai Liu

IPC: C07C235/84 ,  A61K31/165 ,  A61K31/166 ,  A61K31/222 ,  C07C325/02 ,  C07C235/20 ,  C07C235/26 ,  C07C251/24 ,  C07C231/02

Abstract: Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.

公开(公告)号：US20140243553A1

公开(公告)日：2014-08-28

申请号：US14006198

申请日：2012-03-21

Applicant: Guobin Ren ,  Ying Liu ,  Jinyao Chen ,  Xiaoling Huang ,  Lin Xiao ,  Li Cai ,  Zhen Zhang ,  Xuejun Wu ,  Haiyan Sun ,  Quanhai Liu ,  Liling Jin ,  Minyu Liu ,  Yifang Deng ,  Zhiru Xu ,  Renhai Chen ,  Chungang Li ,  Xiangduan Tan ,  Yan Qin

Inventor： Guobin Ren ,  Ying Liu ,  Jinyao Chen ,  Xiaoling Huang ,  Lin Xiao ,  Li Cai ,  Zhen Zhang ,  Xuejun Wu ,  Haiyan Sun ,  Quanhai Liu ,  Liling Jin ,  Minyu Liu ,  Yifang Deng ,  Zhiru Xu ,  Renhai Chen ,  Chungang Li ,  Xiangduan Tan ,  Yan Qin

IPC: C07C227/14 ,  C07C229/38

CPC classification number: C07C227/14 ,  C07C215/10 ,  C07C229/38 ,  C07J63/008

Abstract: An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.

Abstract translation: 一种无定形亚洲氨丁三醇盐及其制备方法。 该方法包括以下步骤：（1）将积雪草酸溶解在有机溶剂中; 步骤（2）与氨丁三醇混合; 步骤（3）搅拌并使其成盐，然后除去有机溶剂。 无定形亚洲氨基丁三醇盐的制备方法容易有效，与现有技术相比，所得到的亚稳氨基甲基胺盐的水溶性和生物利用度大大降低。

公开(公告)号：US06633439B1

公开(公告)日：2003-10-14

申请号：US09714007

申请日：2000-11-16

Applicant: Baoxi Xu ,  Minyu Liu ,  Tow Chong Chong ,  Gaoqiang Yuan

Inventor： Baoxi Xu ,  Minyu Liu ,  Tow Chong Chong ,  Gaoqiang Yuan

IPC: G02B1318

CPC classification number: G11B7/1374 ,  G11B7/122 ,  G11B7/1387 ,  G11B11/10532 ,  G11B11/10554 ,  G11B11/1058 ,  G11B2007/13727

Abstract: The present invention provides an improved optical reading and recording system utilizing optical system employing an aspherical solid immersion lens (SIL). The improved optical system has an aspherical SIL between an objective lens and the recording media. The aspherical SIL reduces the focused electromagnetic radiation beam spot size by providing an increased numeric aperture (NA) of the optical system. The aspherical surface of the SIL provide greater manufacturing and operating tolerances between the objective lens and the aspherical SIL. Greater manufacturing tolerances provide an easier to manufacture optical system. Increased ease of manufacture reduces the cost of optical systems.

Abstract translation: 本发明提供了利用采用非球面固体浸没透镜（SIL）的光学系统的改进的光学读取和记录系统。 改进的光学系统在物镜和记录介质之间具有非球面SIL。 非球面SIL通过提供光学系统的增加的数值孔径（NA）来减少聚焦的电磁辐射束斑点尺寸。 SIL的非球面表面在物镜和非球面SIL之间提供更大的制造和工作公差。 更大的制造公差提供了更容易制造的光学系统。 增加制造的便利性降低光学系统的成本。

公开(公告)号：US08258176B2

公开(公告)日：2012-09-04

申请号：US12676470

申请日：2008-08-29

Applicant: Guoping Wang ,  Quanhai Liu ,  Haiyan Sun ,  Wei Wu ,  Jian Hou ,  Lin Yao ,  Chungang Li ,  Minyu Liu ,  Fei Li ,  Xuejun Wu ,  Shuai Zhao

Inventor： Guoping Wang ,  Quanhai Liu ,  Haiyan Sun ,  Wei Wu ,  Jian Hou ,  Lin Yao ,  Chungang Li ,  Minyu Liu ,  Fei Li ,  Xuejun Wu ,  Shuai Zhao

IPC: A61K31/407 ,  C07D487/04 ,  C07D487/02

CPC classification number: C07D495/04

Abstract: The invention discloses a dithiolopyrrolone compound represented by formula I or its pharmaceutically acceptable salts, wherein X1, R1, R2, R3, R4 are defined as in the description. The invention also discloses the preparation of such compounds, and the use of such compounds in preparation of medicaments for increasing peripheral white blood cells and in preparation of ancillary medicaments for inhibiting the decrease of peripheral white blood cells in radiotherapy or chemotherapy.

Abstract translation: 本发明公开了由式I表示的二硫代环吡咯酮化合物或其药学上可接受的盐，其中X1，R1，R2，R3，R4如描述中所定义。 本发明还公开了这样的化合物的制备，以及这些化合物在制备用于增加外周白细胞的药物中的用途以及用于抑制放射治疗或化学疗法中外周白细胞减少的辅助药物。

公开(公告)号：US20100210856A1

公开(公告)日：2010-08-19

申请号：US12676470

申请日：2008-08-29

Applicant: Guoping Wang ,  Quanhai Liu ,  Haiyan Sun ,  Wei Wu ,  Jian Hou ,  Lin Yao ,  Chungang Li ,  Minyu Liu ,  Fei Li ,  Xuejun Wu ,  Shuai Zhao

Inventor： Guoping Wang ,  Quanhai Liu ,  Haiyan Sun ,  Wei Wu ,  Jian Hou ,  Lin Yao ,  Chungang Li ,  Minyu Liu ,  Fei Li ,  Xuejun Wu ,  Shuai Zhao

IPC: C07D495/04

CPC classification number: C07D495/04

Abstract: The invention discloses a dithiolopyrrolone compound represented by formula I or its pharmaceutically acceptable salts, wherein X1, R1, R2, R3, R4 are defined as in the description. The invention also discloses the preparation of such compounds, and the use of such compounds in preparation of medicaments for increasing peripheral white blood cells and in preparation of ancillary medicaments for inhibiting the decrease of peripheral white blood cells in radiotherapy or chemotherapy.

Abstract translation: 本发明公开了由式I表示的二硫代环吡咯酮化合物或其药学上可接受的盐，其中X1，R1，R2，R3，R4如描述中所定义。 本发明还公开了这样的化合物的制备，以及这些化合物在制备用于增加外周白细胞的药物中的用途以及用于抑制放射治疗或化学疗法中外周白细胞减少的辅助药物。

公开(公告)号：US20070010459A1

公开(公告)日：2007-01-11

申请号：US11333030

申请日：2006-01-17

Applicant: Ying Liu ,  Xingchu Gu ,  Quanhai Liu ,  Longhai Shen ,  Jingzhi Dai ,  Minyu Liu

Inventor： Ying Liu ,  Xingchu Gu ,  Quanhai Liu ,  Longhai Shen ,  Jingzhi Dai ,  Minyu Liu

IPC: A61K31/704 ,  A61K31/20

CPC classification number: A61K31/20 ,  A61K31/704

Abstract: Compositions comprising asiatic acid and its derivatives and asiaticoside and the methods of use there of to treat pulmonary fibrosis are provided.

Abstract translation: 提供了包含积雪草酸及其衍生物和积雪草苷的组合物及其用于治疗肺纤维化的方法。