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公开(公告)号：US20180098953A1
公开(公告)日：2018-04-12
申请号：US15617185
申请日：2017-06-08
IPC分类号： A61K31/198 , A61K33/06 , A61K31/593 , A61K33/08 , A61K33/30
CPC分类号： A61K31/198 , A61K31/593 , A61K33/06 , A61K33/08 , A61K33/30
摘要： A mineral-vitamin complex for osteoporosis includes at least 92 mass % of the mineral-vitamin complex of amino acids and Krebs cycle acids and/or Krebs cycle acid salts, wherein the amino acids include glycine of between 1% and 80% of the mineral-vitamin complex, and wherein the Krebs cycle acids and/or Krebs cycle acid salts are up to 5 mass % of the mineral-vitamin complex; and valine, leucine and isoleucine such that a mass ratio of glycine to a sum of valine+leucine+isoleucine is in a range of 10-1000. Optionally, the valine, leucine and isoleucine are derived from dry milk, any stable dry product derived from milk and/or a mix thereof. Optionally, the following compounds are used as a source of Krebs cycle acid salts: Y-Me-Y.nH2O, where Me—divalent metal, from Ca, Mg, Zn group, Y—anion of an acid participating in Krebs cycle, and n=0-12.
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公开(公告)号：US20120130125A1
公开(公告)日：2012-05-24
申请号：US13061148
申请日：2009-08-24
申请人： Roman Anatolievich Trunin , Mikhail Lvovich Uchitel , Evgenij Iljich Maevskij , Vladimir Izrailevich Heifets , Svetlana Yakovlevna Chernitzkaya , Donna Kasseinova , Galina Nikolaevna Ermakova
发明人： Roman Anatolievich Trunin , Mikhail Lvovich Uchitel , Evgenij Iljich Maevskij , Vladimir Izrailevich Heifets , Svetlana Yakovlevna Chernitzkaya , Donna Kasseinova , Galina Nikolaevna Ermakova
IPC分类号： C07C51/41
CPC分类号： C07C51/43 , C07C51/412 , C07C55/10 , C07C57/15
摘要： An improved process for preparing ammonium salts from fumaric or succinic acid, is described. The method consists of neutralizing the corresponding acid carbonate or ammonium bicarbonate at a molar stoichiometric or greater than the stoichiometric ratio of 4-5% in a saturated aqueous solution of the synthesized salt at a temperature not exceeding 40° C., followed by separation of the product and drying at a temperature not exceeding 70° C. After separation of the ammonium salts, the filtrate can be re-used. Isolation of the product is usually carried out by cooling the reaction mixture to a temperature of 15-18C°. The product comes out in almost crystalline form. Saturated aqueous solution of the synthesized salt is formed by the interaction of carbonate or ammonium bicarbonate with the appropriate acid at a temperature not exceeding 40° C. It is possible to obtain cleaner salt concentration weighing more than 99% and not yielding lower than 98%. The method allows for an increase in the yield of targeted products and ensures their consistent high quality due to their formation in crystalline form.
摘要翻译： 描述了从富马酸或琥珀酸制备铵盐的改进方法。 该方法包括在不超过40℃的温度下，在合成盐的饱和水溶液中以相当于化学计量或大于化学计量比为4-5％的摩尔化学计量比或相对应的酸式碳酸氢铵中和，然后分离 产物并在不超过70℃的温度下干燥。分离出铵盐后，可以重新使用滤液。 产物的分离通常通过将反应混合物冷却至15-18℃的温度来进行。 该产品以几乎结晶的形式出现。 合成的盐的饱和水溶液是通过碳酸氢铵或碳酸氢铵与适当的酸在不超过40℃的温度的相互作用形成的。可以获得重量大于99％且不低于98％的清洁剂盐浓度， 。 该方法允许增加目标产物的产率，并且由于其形成结晶形式，从而确保其一致的高质量。
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公开(公告)号：US20110213183A1
公开(公告)日：2011-09-01
申请号：US13061147
申请日：2009-08-24
申请人： Roman Anatolievich Trunin , Mikhail Lvovich Uchitel , Evgenij Iljich Maevsku , Vladimar Izrailevich Heifets , Sveilana Yakovlevna Chernitzkaya , Donna Kasseinova , Larisa Petrovna Pivonenkova , Tatiana Borisovna Lubimova
发明人： Roman Anatolievich Trunin , Mikhail Lvovich Uchitel , Evgenij Iljich Maevsku , Vladimar Izrailevich Heifets , Sveilana Yakovlevna Chernitzkaya , Donna Kasseinova , Larisa Petrovna Pivonenkova , Tatiana Borisovna Lubimova
IPC分类号： C07C51/36
CPC分类号： B01J23/892 , B01J23/44 , C07C51/36 , C07C51/43 , C07C55/10
摘要： A method for preparing succinic acid, including producing a modified palladium-containing catalyst by using an acid and liquid-phase hydrogenation of unsaturated acid compounds on the modified catalyst at an increased temperature and pressure; separating the catalyst from the succinic acid; wherein the modification of the catalyst is performed on a substrate having the palladium-containing catalyst delivered thereon, the delivery being performed in an oxygen-free atmosphere; the delivery being performed in an aqueous medium of succinic, maleic or fumaric acids and/or their mixtures at a Pd2+/acid ratio of 1:1-1:100; hydrogenating the liquid-phase unsaturated acid compounds selected from maleic, fumaric acids or their anhydrides or their mixtures; and crystallizing the succinic acid from an aqueous solution containing 0.001-0.01 wt. % succinic acid seed.
摘要翻译： 一种制备琥珀酸的方法，包括在升高的温度和压力下，通过在改性催化剂上使用不饱和酸化合物的酸和液相氢化制备改性的含钯催化剂; 将催化剂与琥珀酸分离; 其中所述催化剂的改性在其上交付有所述含钯催化剂的基材上进行，所述输送在无氧气氛中进行; 递送在丁酸，马来酸或富马酸和/或其混合物的水性介质中以1：1-1：100的Pd 2+ /酸比进行; 氢化选自马来酸，富马酸或其酸酐或其混合物的液相不饱和酸化合物; 并从含有0.001-0.01重量％的水溶液中使琥珀酸结晶。 ％琥珀酸种子。
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公开(公告)号：US10130599B2
公开(公告)日：2018-11-20
申请号：US15617185
申请日：2017-06-08
IPC分类号： A61K31/198 , A61K33/06 , A61K33/30 , A61K31/593 , A61K33/08
摘要： A mineral-vitamin complex for osteoporosis includes at least 92 mass % of the mineral-vitamin complex of amino acids and Krebs cycle acids and/or Krebs cycle acid salts, wherein the amino acids include glycine of between 1% and 80% of the mineral-vitamin complex, and wherein the Krebs cycle acids and/or Krebs cycle acid salts are up to 5 mass % of the mineral-vitamin complex; and valine, leucine and isoleucine such that a mass ratio of glycine to a sum of valine+leucine+isoleucine is in a range of 10-1000. Optionally, the valine, leucine and isoleucine are derived from dry milk, any stable dry product derived from milk and/or a mix thereof. Optionally, the following compounds are used as a source of Krebs cycle acid salts: Y-Me-Y.nH2O, where Me—divalent metal, from Ca, Mg, Zn group, Y—anion of an acid participating in Krebs cycle, and n=0-12.
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公开(公告)号：US09845284B1
公开(公告)日：2017-12-19
申请号：US15368618
申请日：2016-12-04
IPC分类号： C07C229/00 , C07C227/18 , C07C51/41
CPC分类号： C07C227/18 , C07C51/418 , C07C57/15 , C07C55/10 , C07C229/24
摘要： A method of obtaining a complex acidic salt of a divalent metal and a dicarboxylic acid includes heating water in a reactor; adding a dicarboxylic acid to the heated water; stirring the water to dissolve the dicarboxylic acid in the heated water to produce a solution or a suspension of the dicarboxylic acid in the heated water; adding MeO to the solution or the suspension, where Me is a divalent metal; continuing the stirring of the solution or suspension until formation of the complex acidic salt Me(AcH)2.nH2O begins, where Ac is an anion of the dicarboxylic acid, and n=0-8; cooling the complex acidic salt to below a temperature of crystallization; sedimenting the complex acidic salt; filtering the complex acidic salt to remove water from the complex acidic salt; and drying the complex acidic salt.
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公开(公告)号：US08933271B2
公开(公告)日：2015-01-13
申请号：US13061148
申请日：2009-08-24
申请人： Roman Anatolievich Trunin , Mikhail Lvovich Uchitel , Evgenij Iljich Maevskij , Donna Kasseinova , Galina Nikolaevna Ermakova , Svetlana Yakovlevna Chernitzkaya
发明人： Roman Anatolievich Trunin , Mikhail Lvovich Uchitel , Evgenij Iljich Maevskij , Vladimir Izrailevich Heifets , Donna Kasseinova , Galina Nikolaevna Ermakova
CPC分类号： C07C51/43 , C07C51/412 , C07C55/10 , C07C57/15
摘要： An improved process for preparing ammonium salts from fumaric or succinic acid, is described. The method consists of neutralizing the corresponding acid carbonate or ammonium bicarbonate at a molar stoichiometric or greater than the stoichiometric ratio of 4-5% in a saturated aqueous solution of the synthesized salt at a temperature not exceeding 40° C., followed by separation of the product and drying at a temperature not exceeding 70° C. After separation of the ammonium salts, the filtrate can be re-used. Isolation of the product is usually carried out by cooling the reaction mixture to a temperature of 15-18 C.°. The product comes out in almost crystalline form. Saturated aqueous solution of the synthesized salt is formed by the interaction of carbonate or ammonium bicarbonate with the appropriate acid at a temperature not exceeding 40° C. It is possible to obtain cleaner salt concentration weighing more than 99% and not yielding lower than 98%. The method allows for an increase in the yield of targeted products and ensures their consistent high quality due to their formation in crystalline form.
摘要翻译： 描述了从富马酸或琥珀酸制备铵盐的改进方法。 该方法包括在不超过40℃的温度下，在合成盐的饱和水溶液中以相当于化学计量或大于化学计量比为4-5％的摩尔化学计量比或相对应的酸式碳酸氢铵中和，然后分离 产物并在不超过70℃的温度下干燥。分离出铵盐后，可以重新使用滤液。 产物的分离通常通过将反应混合物冷却至15-18℃的温度来进行。 该产品以几乎结晶的形式出现。 合成的盐的饱和水溶液是通过碳酸氢铵或碳酸氢铵与适当的酸在不超过40℃的温度的相互作用形成的。可以获得重量大于99％且不低于98％的清洁剂盐浓度， 。 该方法允许增加目标产物的产率，并且由于其形成结晶形式，从而确保其一致的高质量。
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公开(公告)号：US08546611B2
公开(公告)日：2013-10-01
申请号：US13061147
申请日：2009-08-24
申请人： Roman Anatolievich Trunin , Mikhail Lvovich Uchitel , Evgenij Iljich Maevskij , Donna Kasseinova , Larisa Petrovna Pivonenkova , Tatiana Borisovna Lubimova , Svetlana Yakovlevna Chernitzkaya
发明人： Roman Anatolievich Trunin , Mikhail Lvovich Uchitel , Evgenij Iljich Maevskij , Vladimir Izrailevich Heifets , Donna Kasseinova , Larisa Petrovna Pivonenkova , Tatiana Borisovna Lubimova
CPC分类号： B01J23/892 , B01J23/44 , C07C51/36 , C07C51/43 , C07C55/10
摘要： A method for preparing succinic acid, including producing a modified palladium-containing catalyst by using an acid and liquid-phase hydrogenation of unsaturated acid compounds on the modified catalyst at an increased temperature and pressure; separating the catalyst from the succinic acid; wherein the modification of the catalyst is performed on a substrate having the palladium-containing catalyst delivered thereon, the delivery being performed in an oxygen-free atmosphere; the delivery being performed in an aqueous medium of succinic, maleic or fumaric acids and/or their mixtures at a Pd2+/acid ratio of 1:1-1:100; hydrogenating the liquid-phase unsaturated acid compounds selected from maleic, fumaric acids or their anhydrides or their mixtures; and crystallizing the succinic acid from an aqueous solution containing 0.001-0.01 wt. % succinic acid seed.
摘要翻译： 一种制备琥珀酸的方法，包括在升高的温度和压力下，通过在改性催化剂上使用不饱和酸化合物的酸和液相氢化制备改性的含钯催化剂; 将催化剂与琥珀酸分离; 其中所述催化剂的改性在其上交付有所述含钯催化剂的基材上进行，所述输送在无氧气氛中进行; 递送在丁酸，马来酸或富马酸和/或其混合物的水性介质中以1：1-1：100的Pd 2+ /酸比进行; 氢化选自马来酸，富马酸或其酸酐或其混合物的液相不饱和酸化合物; 并从含有0.001-0.01重量％的水溶液中使琥珀酸结晶。 ％琥珀酸种子。
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