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    Method and sysem for non-ablative acne treatment and prevention
    1.
    发明授权
    Method and sysem for non-ablative acne treatment and prevention 有权
    非烧蚀性痤疮治疗和预防的方法和系统

    公开(公告)号：US09566454B2

    公开(公告)日：2017-02-14

    申请号：US11738682

    申请日：2007-04-23

    Applicant: Peter G. Barthe ,  Michael H. Slayton ,  Inder Raj S. Makin

    Inventor： Peter G. Barthe ,  Michael H. Slayton ,  Inder Raj S. Makin

    IPC: A61N7/02 ,  A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61N7/00 ,  A61B8/00 ,  A61M37/00

    CPC classification number: A61N7/02 ,  A61B8/4272 ,  A61B2017/00747 ,  A61B2017/22008 ,  A61B2018/00666 ,  A61M37/0092 ,  A61N7/00 ,  A61N2007/0008 ,  A61N2007/0078

    Abstract: A method and system for non-ablative acne treatment and prevention is disclosed. The method utilizes ultrasound energy which is targeted at a region of interest to treat existing acne and prevent future acne from forming. The application of ultrasound energy causes numerous physiological effects that treat acne. Some of these physiological effects comprise reducing sebum, increasing perfusion at the region of interest, denaturing proteins at the region of interest, creating an uninhabitable environment at the region of interest, initiating programmed cell death at the region of interest and the initiation of mechanical effects at the region of interest.

    Abstract translation: 公开了一种用于非烧蚀性痤疮治疗和预防的方法和系统。 该方法利用针对感兴趣区域的超声能量来治疗现有的痤疮并防止将来的痤疮形成。 超声能量的应用导致许多治疗痤疮的生理效应。 这些生理作用中的一些包括减少皮脂，增加感兴趣区域的灌注，在感兴趣的区域变性蛋白质，在感兴趣的区域产生不适宜的环境，在感兴趣的区域启动程序性细胞死亡并引发机械效应 在感兴趣的地区。

    Methods and systems for modulating medicants using acoustic energy
    3.
    发明授权
    Methods and systems for modulating medicants using acoustic energy 有权
    使用声能调节药物的方法和系统

    公开(公告)号：US09216276B2

    公开(公告)日：2015-12-22

    申请号：US12116810

    申请日：2008-05-07

    Applicant: Michael H. Slayton ,  Peter G. Barthe ,  Inder Raj S. Makin

    Inventor： Michael H. Slayton ,  Peter G. Barthe ,  Inder Raj S. Makin

    IPC: A61M37/00 ,  A61N7/00 ,  A61N7/02 ,  A61B19/00 ,  A61B8/00

    CPC classification number: A61M37/0092 ,  A61B8/4281 ,  A61B2090/378 ,  A61M2037/0007 ,  A61M2205/3375 ,  A61N7/00 ,  A61N7/02 ,  A61N2007/0008 ,  A61N2007/0043 ,  A61N2007/0056

    Abstract: This invention provides methods and systems uniquely capable of enhancing medicant delivery and/or effectiveness through the use of energy to predictably disrupt membranes and mechanically and thermally modulate cells and tissues. In exemplary embodiments, the methods and systems disclosed herein are capable of modulating multiple layers of tissue. In an exemplary embodiment, the energy is acoustic energy (e.g., ultrasound). In other exemplary embodiments, the energy is photon based energy (e.g., IPL, LED, laser, white light, etc.), or other energy forms, such radio frequency electric currents, or various combinations of acoustic energy, electromagnetic energy and other energy forms or energy absorbers such as cooling. Medicants can be first introduced to the region of interest by diffusion, circulation, and/or injection. An exemplary system for enhancing medicant delivery and/or effectiveness comprises a control system, a probe, and a display or indicator system. Imaging and/or monitoring may alternatively be coupled and/or co-housed with an ultrasound system contemplated by the present invention.

    Abstract translation: 本发明提供了能够通过使用能量来预测性地破坏膜并机械和热调节细胞和组织来增强药物递送和/或有效性的方法和系统。 在示例性实施例中，本文公开的方法和系统能够调制多层组织。 在示例性实施例中，能量是声能（例如，超声）。 在其它示例性实施例中，能量是基于光子的能量（例如，IPL，LED，激光，白光等）或其他能量形式，例如射频电流，或声能，电磁能和其他能量的各种组合 形式或能量吸收器如冷却。 首先通过扩散，循环和/或注射将药物引入感兴趣的区域。 用于增强药物递送和/或有效性的示例性系统包括控制系统，探针和显示器或指示器系统。 可以与本发明预期的超声系统可以联接和/或共同成像和/或监视。

    Method and system for ultrasound treatment with a multi-directional transducer
    4.
    发明授权
    Method and system for ultrasound treatment with a multi-directional transducer 有权
    用多向传感器进行超声处理的方法和系统

    公开(公告)号：US09114247B2

    公开(公告)日：2015-08-25

    申请号：US13294004

    申请日：2011-11-10

    Applicant: Peter G. Barthe ,  Michael H. Slayton

    Inventor： Peter G. Barthe ,  Michael H. Slayton

    IPC: A61B8/00 ,  A61N7/02 ,  A61B17/00 ,  A61B19/00 ,  A61N7/00

    CPC classification number: A61N7/022 ,  A61B8/4272 ,  A61B2017/00084 ,  A61B2090/378 ,  A61N2007/0078

    Abstract: A method and system for ultrasound treatment utilizing a multi-directional transducer to facilitate treatment, such as therapy and/or imaging or other tissue parameter monitoring, in two or more directions. In accordance with an exemplary embodiment, a multi-directional transducer comprises at least two transduction elements configured to provide for ultrasound energy, such as radiation, acoustical energy, heat energy, imaging, positional information and/or tissue parameter monitoring signals in two or more directions. The transduction elements can comprise various materials for providing ultrasound energy or radiation, such as piezoelectric materials, with and without matching layers. In addition, the transduction elements can be configured for substantially uniform, focused and/or defocused radiation patterns, as well as for single, multiple-element and/or multiple-element array configurations. In addition, an exemplary multi-directional transducer can comprise multiple elements, either side by side, stacked or in an array.

    Abstract translation: 一种利用多向换能器来促进诸如在两个或更多个方向上的治疗和/或成像或其它组织参数监测的治疗的超声治疗的方法和系统。 根据示例性实施例，多方向换能器包括至少两个换能元件，所述至少两个换能元件被配置为提供两个或更多个超声波能量，例如辐射，声能，热能，成像，位置信息和/或组织参数监测信号 方向。 转导元件可以包括用于提供超声能量或辐射的各种材料，例如具有和不具有匹配层的压电材料。 此外，转导元件可以被配置为基本上均匀的，聚焦的和/或散焦的辐射图，以及用于单个，多元件和/或多元件阵列配置。 此外，示例性多向换能器可以包括多个元件，并排，堆叠或阵列。

    Methods and systems for coupling and focusing acoustic energy using a coupler member
    6.
    发明授权
    Methods and systems for coupling and focusing acoustic energy using a coupler member 有权
    使用耦合器部件耦合和聚焦声能的方法和系统

    公开(公告)号：US08764687B2

    公开(公告)日：2014-07-01

    申请号：US12116828

    申请日：2008-05-07

    Applicant: Michael H Slayton ,  Peter G. Barthe ,  Paul M. Jaeger

    Inventor： Michael H Slayton ,  Peter G. Barthe ,  Paul M. Jaeger

    IPC: A61N7/00

    CPC classification number: A61B8/4281 ,  A61K49/226 ,  G10K11/02 ,  G10K11/30

    Abstract: An exemplary system for coupling acoustic energy using an encapsulated coupler member comprises a display or indicator, a control system, a probe, and a coupler member. This invention provides a coupler member adjustably configured to perform at least one of (i) providing a standoff, (ii) focusing or defocusing energy, and (iii) coupling energy. An exemplary gel coupler member is configured to hold the shape of a lens geometry. In one aspect of the present invention, gel coupler member comprises water, glycerol, and polyvinyl alcohol, and exhibits an increased desiccation time and shelf life when compared to the prior art. The probe can comprise various probe and/or transducer configurations. In an exemplary embodiment, the probe delivers focused, unfocused, and/or defocused ultrasound energy to the region of interest. Imaging and/or monitoring may alternatively be coupled and/or co-housed with an ultrasound system contemplated by the present invention.

    Abstract translation: 使用封装的耦合器部件耦合声能的示例性系统包括显示器或指示器，控制系统，探针和耦合器部件。 本发明提供一种可调节地配置成执行（i）提供支座，（ii）聚焦或散焦能量和（iii）耦合能量中的至少一个的耦合器部件。 示例性的凝胶耦合器构件被配置为保持透镜几何形状。 在本发明的一个方面，凝胶偶联剂包含水，甘油和聚乙烯醇，并且与现有技术相比表现出增加的干燥时间和保存期限。 探头可以包括各种探头和/或换能器构造。 在示例性实施例中，探针将聚焦的，未聚焦的和/或散焦的超声能量传递到感兴趣的区域。 可以与本发明预期的超声系统可以联接和/或共同成像和/或监视。

    Visual imaging system for ultrasonic probe
    7.
    发明授权
    Visual imaging system for ultrasonic probe 有权

    公开(公告)号：US08409097B2

    公开(公告)日：2013-04-02

    申请号：US13071298

    申请日：2011-03-24

    Applicant: Michael H Slayton ,  Peter G Barthe

    Inventor： Michael H Slayton ,  Peter G Barthe

    IPC: A61B8/00

    CPC classification number: A61B8/4263 ,  A61B8/00 ,  A61B8/42 ,  A61B8/4245 ,  A61B8/4427 ,  A61B8/463

    Abstract: A non-invasive visual imaging system is provided, wherein the imaging system procures an image of a transducer position during diagnostic or therapeutic treatment. In addition, the system suitably provides for the transducer to capture patient information, such as acoustic, temperature, or ultrasonic images. For example, an ultrasonic image captured by the transducer can be correlated, fused or otherwise combined with the corresponding positional transducer image, such that the corresponding images represent not only the location of the transducer with respect to the patient, but also the ultrasonic image of the region of interest being scanned. Further, a system is provided wherein the information relating to the transducer position on a single patient may be used to capture similar imaging planes on the same patient, or with subsequent patients. Moreover, the imaging information can be effectively utilized as a training tool for medical practitioners.

    METHODS FOR TREATMENT OF HYPERHIDROSIS
    9.
    发明申请
    METHODS FOR TREATMENT OF HYPERHIDROSIS 有权
    治疗高血压的方法

    公开(公告)号：US20120330222A1

    公开(公告)日：2012-12-27

    申请号：US13603159

    申请日：2012-09-04

    Applicant: Inder Raj S. Makin ,  Peter G. Barthe ,  Michael H. Slayton

    Inventor： Inder Raj S. Makin ,  Peter G. Barthe ,  Michael H. Slayton

    IPC: A61B18/04 ,  A61M37/00

    CPC classification number: A61N7/02 ,  A61B8/4281 ,  A61B17/320068 ,  A61B2018/00005 ,  A61N7/00 ,  A61N2007/0004 ,  A61N2007/0052 ,  A61N2007/0078

    Abstract: Methods for ultrasound treatment of hyperhidrosis are provided. Various methods and systems for targeted treatment of sweat glands can be configured in various manners, such as through use of therapy only, therapy and monitoring, imaging and therapy, or therapy, imaging, and monitoring, and/or through use of focused, unfocused, or defocused ultrasound through control of various spatial and temporal parameters. As a result, thermal and/or ablative energy can be deposited at the particular depth at which the sweat gland population is located below the skin surface. Ultrasound and non-ultrasound treatments for hyperhidrosis are provided.

    Abstract translation: 提供超声治疗多汗症的方法。 用于针对性治疗汗腺的各种方法和系统可以以各种方式配置，例如仅通过使用治疗，治疗和监测，成像和治疗，或治疗，成像和监测，和/或通过使用集中的，未聚焦的 ，或通过控制各种空间和时间参数来散焦超声波。 结果，热汗和/或烧蚀能量可以沉积在汗腺群体位于皮肤表面下方的特定深度处。 提供超声和非超声治疗多汗症。

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