公开(公告)号：US20210008042A1

公开(公告)日：2021-01-14

申请号：US17028300

申请日：2020-09-22

申请人： MedRegen, LLC

发明人： Zhaoli Sun ,  George Melville Williams

IPC分类号： A61K31/436 ,  A61K38/13 ,  A61K38/19 ,  A61K45/06 ,  A61K31/00 ,  A61K31/395

摘要： The present invention related to the field of organ transplantation. In one aspect, the present invention provides methods of treating an organ transplant recipient comprising administering to the recipient a therapeutically effective amount of a stem cell mobilizer and an immunosuppressive agent. In particular embodiments, the present invention provides a method of treating an organ transplant recipient comprising administering to the recipient a therapeutically effective amount of an agent that mobilizes CD34+ and/or CD133+ stem cells and a low dose of immunosuppressive agent.

公开(公告)号：US12048687B2

公开(公告)日：2024-07-30

申请号：US17166568

申请日：2021-02-03

申请人： MedRegen, LLC

发明人： Zhaoli Sun ,  George Melville Williams ,  Qing Lin

IPC分类号： A61K31/395 ,  A61K31/436 ,  A61K31/4427 ,  A61K31/5377 ,  A61K38/13 ,  A61K38/18 ,  A61K38/19 ,  A61K45/06 ,  A61P17/02

CPC分类号： A61K31/395 ,  A61K31/436 ,  A61K31/4427 ,  A61K31/5377 ,  A61K38/13 ,  A61K38/18 ,  A61K38/193 ,  A61K45/06 ,  A61P17/02 ,  A61K31/395 ,  A61K2300/00 ,  A61K31/4427 ,  A61K2300/00 ,  A61K31/436 ,  A61K2300/00 ,  A61K31/5377 ,  A61K2300/00 ,  A61K38/193 ,  A61K2300/00 ,  A61K38/13 ,  A61K2300/00 ,  A61K38/18 ,  A61K2300/00

摘要： The present invention relates to the field of wound healing. More specifically, the present invention provides methods and compositions useful for improved wound healing via autologous stem cell mobilization. In one embodiment, a method for improving wound healing in a patient comprises administering to the patient a therapeutically effective amount of a stem cell mobilizer and a low dose of an immunosuppressive agent.

公开(公告)号：US10420751B2

公开(公告)日：2019-09-24

申请号：US14814988

申请日：2015-07-31

申请人： MedRegen, LLC

发明人： Zhaoli Sun ,  Xuhang Li

IPC分类号： A61K31/436 ,  A61K31/395 ,  A61K31/00

摘要： The present invention relates to the field of inflammatory bowel disease. In one aspect, the present invention provides methods for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of a stem cell mobilizer and an immunosuppressive agent. In particular embodiments, the present invention provides a method for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of an agent that mobilizes CD34+ and/or CD133+ stem cells and a low dose of an immunosuppressive agent.

公开(公告)号：US12115149B2

公开(公告)日：2024-10-15

申请号：US17523323

申请日：2021-11-10

申请人： MedRegen, LLC

发明人： Zhaoli Sun ,  John Sun ,  Christy Eatmon ,  Rachel Labell ,  Zhimin Liu ,  Richard Brewer ,  Isaac Agyemang ,  Mitchell Williams

IPC分类号： A61K31/436 ,  A61K9/00 ,  A61K31/495 ,  A61K47/02 ,  A61K47/10 ,  A61K47/22 ,  A61P11/00 ,  A61P29/00

CPC分类号： A61K31/436 ,  A61K9/0019 ,  A61K31/495 ,  A61K47/02 ,  A61K47/10 ,  A61K47/22 ,  A61P11/00 ,  A61P29/00

摘要： Embodiments of the disclosure relate generally to formulations, methods, kits, and dosage forms for improved stability comprising at least two active ingredients, AMD3100, or similar stem cell mobilizer, and Tacrolimus, or FK506 derivative or analog, and one or more excipients. The formulations may be administered as a single dose subcutaneous injection. The formulations may be useful in treating various diseases, disorders or injuries.

公开(公告)号：US11291657B2

公开(公告)日：2022-04-05

申请号：US16540985

申请日：2019-08-14

申请人： MedRegen, LLC

发明人： Zhaoli Sun ,  Xuhang Li

IPC分类号： A61K31/436 ,  A61K38/13 ,  A61K31/395 ,  A61K45/06 ,  A61K31/00 ,  A61K38/19

摘要： The present invention relates to the field of inflammatory bowel disease. In one aspect, the present invention provides methods for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of a stem cell mobilizer and an immunosuppressive agent. In particular embodiments, the present invention provides a method for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of an agent that mobilizes CD34+ and/or CD133+ stem cells and a low dose of an immunosuppressive agent.

公开(公告)号：US20220142992A1

公开(公告)日：2022-05-12

申请号：US17523323

申请日：2021-11-10

申请人： MedRegen, LLC

发明人： Zhaoli Sun ,  John Sun ,  Jared Griffin ,  Christy Eatmon ,  Rachel Labell ,  Zhimin Liu ,  Richard Brewer ,  Issac Agyemang ,  Mitchell Williams

IPC分类号： A61K31/436 ,  A61K31/495 ,  A61K47/10 ,  A61K47/22 ,  A61K47/02 ,  A61K9/00 ,  A61P11/00 ,  A61P29/00

摘要： Embodiments of the disclosure relate generally to formulations, methods, kits, and dosage forms for improved stability comprising at least two active ingredients, AMD3100, or similar stem cell mobilizer, and Tacrolimus, or FK506 derivative or analog, and one or more excipients. The formulations may be administered as a single dose subcutaneous injection. The formulations may be useful in treating various diseases, disorders or injuries.

公开(公告)号：US20200038381A1

公开(公告)日：2020-02-06

申请号：US16540985

申请日：2019-08-14

申请人： MedRegen, LLC

发明人： Zhaoli Sun ,  Xuhang Li

IPC分类号： A61K31/436 ,  A61K38/13 ,  A61K38/19 ,  A61K45/06 ,  A61K31/00 ,  A61K31/395

摘要： The present invention relates to the field of inflammatory bowel disease. In one aspect, the present invention provides methods for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of a stem cell mobilizer and an immunosuppressive agent. In particular embodiments, the present invention provides a method for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of an agent that mobilizes CD34+ and/or CD133+ stem cells and a low dose of an immunosuppressive agent.

公开(公告)号：US20190314344A9

公开(公告)日：2019-10-17

申请号：US14814988

申请日：2015-07-31

申请人： MedRegen, LLC

发明人： Zhaoli Sun ,  Xuhang Li

IPC分类号： A61K31/436 ,  A61K31/395

摘要： The present invention relates to the field of inflammatory bowel disease. In one aspect, the present invention provides methods for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of a stem cell mobilizer and an immunosuppressive agent. In particular embodiments, the present invention provides a method for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of an agent that mobilizes CD34+ and/or CD133+ stem cells and a low dose of an immunosuppressive agent.

公开(公告)号：US20230255931A1

公开(公告)日：2023-08-17

申请号：US18189741

申请日：2023-03-24

申请人： MedRegen, LLC

发明人： Zhaoli Sun

IPC分类号： A61K31/395 ,  A61K9/00 ,  A61K9/08 ,  A61K31/506 ,  A61K31/4427 ,  A61K45/06 ,  A61K47/44 ,  A61K47/10 ,  A61K31/436 ,  A61P17/02 ,  A61P1/00 ,  A61P29/00

CPC分类号： A61K31/395 ,  A61K9/08 ,  A61K9/0019 ,  A61K31/436 ,  A61K31/506 ,  A61K31/4427 ,  A61K45/06 ,  A61K47/10 ,  A61K47/44 ,  A61P1/00 ,  A61P17/02 ,  A61P29/00

摘要： The present invention relates to the field of tissue injury. More specifically, the present invention provides pharmaceutical compositions useful for the treatment of tissue injury. In certain embodiments, a pharmaceutical composition comprises (a) a stem cell mobilizer and (b) an immunosuppressive agent or non-immunosuppressive FK binding protein ligand. The pharmaceutical compositions of the invention can be administered by a variety of routes and dosing regimens.

公开(公告)号：US20220184043A1

公开(公告)日：2022-06-16

申请号：US17684959

申请日：2022-03-02

申请人： MedRegen, LLC

发明人： Zhaoli Sun ,  Xuhang Li

IPC分类号： A61K31/436 ,  A61K38/13 ,  A61K31/395 ,  A61K45/06 ,  A61K31/00 ,  A61K38/19

摘要： The present invention relates to the field of inflammatory bowel disease. In one aspect, the present invention provides methods for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of a stem cell mobilizer and an immunosuppressive agent. In particular embodiments, the present invention provides a method for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of an agent that mobilizes CD34+ and/or CD133+ stem cells and a low dose of an immunosuppressive agent.