公开(公告)号：US10287242B2

公开(公告)日：2019-05-14

申请号：US14369410

申请日：2012-05-04

申请人： Dilip S. Mehta ,  Mayank Shastri

发明人： Dilip S. Mehta ,  Mayank Shastri

IPC分类号： C07C229/00 ,  C07C277/08

摘要： The present invention is related to synthesis of highly pure cationic surfactant products by eliminating or reducing impurities generation that has beset prior art. This is achieved through the N-acylation of ester of amino acid and its inorganic salts or its organic salts (e.g. amino acid or hydrochloride of amino acid or sulfate of amino acid or acetate of amino acid etc.) in non-hydrolytic or nearly non-hydrolytic reaction conditions involving mono or biphasic reaction system with fatty acid halide (C4 to C20), under moderate uniform basic condition yielding high purity N-acyl substituted amino acid ester, particularly ethyl lauroyl arginate. The present process achieves pH control through process strategy rather than the measurement and control steps. This ambient temperature process is stable through a range of temperature variation eliminating rigid low temperature control.

公开(公告)号：US09464021B2

公开(公告)日：2016-10-11

申请号：US14530250

申请日：2014-10-31

申请人： Dilip S. Mehta ,  Priya Mohan ,  Mayank Shastri ,  Ted Reid

发明人： Dilip S. Mehta ,  Priya Mohan ,  Mayank Shastri ,  Ted Reid

IPC分类号： C07C69/76 ,  C07C46/00 ,  C07C69/734 ,  C07C41/18 ,  C07D339/08 ,  C07C45/56 ,  C07C46/02 ,  C07C69/618

CPC分类号： C07C46/00 ,  C07C41/18 ,  C07C45/567 ,  C07C46/02 ,  C07C69/618 ,  C07C69/734 ,  C07D339/08 ,  C07C49/255 ,  C07C43/215 ,  C07C50/14

摘要： The description provides processes for the regio and stereospecific synthesis of polyprenylatedquinone derivatives, such as Vitamin K1, K2 and Ubiquinone, exploiting dithioacetals, especially 1,3-dithiane, mediated Umpolung chemistry which works along a new concept “Inhibiting resonance delocalization (IRD)” to overcome isomerization generated due to delocalization of allyliccarbanion on the π-electron cloud of an allylic systems by the conventional synthesis.

摘要翻译： 该描述提供了聚异戊二烯基化醌衍生物如维生素K1，K2和泛醌的区域和立体特异性合成的方法，利用二硫缩醛，特别是1,3-二噻吩介导的Umpolung化学，其沿着新概念“抑制共振离域（IRD）”工作） 以克服由于通过常规合成在烯丙基系统的π电子云上的烯丙基碳阴离子离域产生的异构化。

公开(公告)号：US20150126763A1

公开(公告)日：2015-05-07

申请号：US14530250

申请日：2014-10-31

申请人： Dilip S. Mehta ,  Priya Mohan ,  Mayank Shastri ,  Ted Reid

发明人： Dilip S. Mehta ,  Priya Mohan ,  Mayank Shastri ,  Ted Reid

IPC分类号： C07C46/00 ,  C07C69/618

CPC分类号： C07C46/00 ,  C07C41/18 ,  C07C45/567 ,  C07C46/02 ,  C07C69/618 ,  C07C69/734 ,  C07D339/08 ,  C07C49/255 ,  C07C43/215 ,  C07C50/14

摘要： The description provides processes for the regio and stereospecific synthesis of polyprenylatedquinone derivatives, such as Vitamin K1, K2 and Ubiquinone, exploiting dithioacetals, especially 1,3-dithiane, mediated Umpolung chemistry which works along a new concept “Inhibiting resonance delocalization (IRD)” to overcome isomerization generated due to delocalization of allyliccarbanion on the π-electron cloud of an allylic systems by the conventional synthesis.

摘要翻译： 该描述提供了聚异戊二烯基化醌衍生物如维生素K1，K2和泛醌的区域和立体特异性合成的方法，利用二硫缩醛，特别是1,3-二噻吩介导的Umpolung化学，其沿着新概念“抑制共振离域（IRD）”工作） 克服由于通过常规合成在烯丙基系统的电子云上的烯丙基碳阴离子的离域产生的异构化。

公开(公告)号：US20140323756A1

公开(公告)日：2014-10-30

申请号：US14369410

申请日：2012-05-04

申请人： Dilip S. Mehta ,  Mayank Shastri

发明人： Dilip S. Mehta ,  Mayank Shastri

IPC分类号： C07C277/08

CPC分类号： C07C277/08 ,  C07C279/14

摘要： The present invention is related to synthesis of highly pure cationic surfactant products by eliminating or reducing impurities generation that has beset prior art. This is achieved through the N-acylation of ester of amino acid and its inorganic salts or its organic salts (e.g. amino acid or hydrochloride of amino acid or sulfate of amino acid or acetate of amino acid etc.) in non-hydrolytic or nearly non-hydrolytic reaction conditions involving mono or biphasic reaction system with fatty acid halide (C4 to C20), under moderate uniform basic condition yielding high purity N-acyl substituted amino acid ester, particularly ethyl lauroyl arginate. The present process achieves pH control through process strategy rather than the measurement and control steps. This ambient temperature process is stable through a range of temperature variation eliminating rigid low temperature control.

摘要翻译： 本发明涉及通过消除或减少现有技术中杂质产生来合成高纯度阳离子表面活性剂产品。 这是通过氨基酸及其无机盐或其有机盐（例如氨基酸或氨基酸的硫酸盐或氨基酸的乙酸盐的氨基酸或盐酸盐）的N-酰化在非水解或几乎不 水解反应条件涉及单或双相反应体系与脂肪酰卤（C4至C20），在中等均匀碱性条件下，产生高纯度N-酰基取代的氨基酸酯，特别是精氨酸月桂酸乙酯。 本方法通过过程策略而不是测量和控制步骤实现pH控制。 这种环境温度过程通过一系列温度变化而稳定，消除了刚性低温控制。