公开(公告)号：US20090156582A1

公开(公告)日：2009-06-18

申请号：US11884054

申请日：2006-02-09

申请人： Tetsuya Tsukamoto ,  Takeshi Yamamoto ,  Ryosuke Tokunoh ,  Tomohiro Kawamoto ,  Masahiro Okura ,  Masakumi Kori ,  Katsuhito Murase

发明人： Tetsuya Tsukamoto ,  Takeshi Yamamoto ,  Ryosuke Tokunoh ,  Tomohiro Kawamoto ,  Masahiro Okura ,  Masakumi Kori ,  Katsuhito Murase

IPC分类号： A61K31/55 ,  A61K31/454 ,  A61K31/4162 ,  C07D403/02

CPC分类号： C07D231/38 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14

摘要： The present invention provides a pyrazole compound represented by the formula (I): wherein ring A0 is a pyrazole ring optionally further having 1 or 2 substituents; Ra is a substituted carbamoyl group; and Rb is an optionally substituted acylamino group, or a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of GSK-3β related pathology or disease, and a GSK-3β inhibitor including same.

摘要翻译： 本发明提供由式（I）表示的吡唑化合物：其中环A0是任选还含有1或2个取代基的吡唑环; Ra是取代的氨基甲酰基; 和Rb是可用作预防或治疗GSK-3β相关病理学或疾病的药剂的任选取代的酰基氨基或其盐或其前药，以及包含GSK-3β抑制剂的GSK-3β抑制剂。