公开(公告)号：US20150197489A1

公开(公告)日：2015-07-16

申请号：US14671435

申请日：2015-03-27

申请人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

发明人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

IPC分类号： C07C319/20

CPC分类号： C07C319/20 ,  C07C323/60 ,  C07C323/58 ,  C07C323/52

摘要： A method to produce D,L-Methionine from 2-hydroxy-4-(methylthio)butyronitrile by reaction with ammonia, optionally in the presence of carbon dioxide, is provided. The 2-hydroxy-4-(methylthio)butyronitrile is obtained by reaction of 3-methylmercapto-propionaldehyde with hydrogen cyanide in the presence of a base as catalyst in a main reaction zone of a multizone reactor. Residual gaseous hydrogen cyanide is removed from the main reaction zone to an absorption and post-reaction zone of the reactor which comprises a mixture of 3-methylmercaptopropionaldehyde and the catalyst; and the gaseous hydrogen cyanide is further reacted with the 3-methylmercaptopropionaldehyde in the absorption and post reaction zone. A molar ratio of hydrogen cyanide to 3-(methylthio)propanal in the main reaction zone is from 0.98 to 1.03.

摘要翻译： 提供了通过与氨反应，任选在二氧化碳存在下，由2-羟基-4-（甲硫基）丁腈生成D，L-甲硫氨酸的方法。 2-羟基-4-（甲硫基）丁腈是通过在多基团反应器的主反应区中作为催化剂的碱作为催化剂使3-甲基巯基丙醛与氰化氢反应得到的。 残留的气态氰化氢从主反应区除去反应器的吸收和后反应区，其包含3-甲基巯基丙醛和催化剂的混合物; 并且氰化氢气体在吸收和后反应区域中与3-甲基巯基丙醛进一步反应。 主反应区氰化氢与3-（甲硫基）丙醛的摩尔比为0.98-1.03。

公开(公告)号：US20160263558A1

公开(公告)日：2016-09-15

申请号：US15028415

申请日：2014-10-02

申请人： Martin STEURENTHALER ,  Thomas MÜLLER ,  Martin KÖRFER ,  Steffen KRILL ,  EVONIK DEGUSSA GMBH ,  Martin STEFAN

发明人： Martin Steffan ,  Martin Steurenthaler ,  Thomas Müller ,  Martin Körfer ,  Steffen Krill

IPC分类号： B01J23/42 ,  B01J21/04 ,  C01C3/02 ,  B01J35/04

CPC分类号： B01J23/42 ,  B01J12/007 ,  B01J19/0026 ,  B01J19/006 ,  B01J19/2415 ,  B01J21/04 ,  B01J35/04 ,  B01J2219/0263 ,  B01J2219/30242 ,  C01C3/0229

摘要： The reaction tube for preparing hydrogen cyanide comprises a cylindrical tube composed of ceramic, a catalyst comprising platinum applied to the inner wall of the tube and also at least one insert composed of ceramic, having three or four fins pointing from the tube axis to the inner wall of the tube, which is inserted into the cylindrical tube, wherein the fins divide the tube interior space into substantially straight channels with substantially identical circle segment cross sections and wherein the mean gap between the ends of the fins and the inner wall of the tube is in the range of 0.1 to 3 mm. In the method for preparing hydrogen cyanide, ammonia and at least one aliphatic hydrocarbon having 1 to 4 carbon atoms are reacted in the reaction tube at 1000 to 1400° C.

摘要翻译： 用于制备氰化氢的反应管包括由陶瓷构成的圆柱形管，包含铂的催化剂，其施加到管的内壁上，还包括至少一个由陶瓷组成的插入件，具有从管轴指向内部的三个或四个翅片 插入圆柱形管中的管的壁，其中翅片将管内部空间划分成具有基本相同的圆形截面的基本上直的通道，并且其中翅片的端部与管的内壁之间的平均间隙 在0.1〜3mm的范围内。 在制备氰化氢的方法中，氨和至少一种具有1至4个碳原子的脂族烃在反应管中在1000-1400℃下反应。

公开(公告)号：US20120215022A1

公开(公告)日：2012-08-23

申请号：US13402041

申请日：2012-02-22

申请人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

发明人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

IPC分类号： C07C51/08 ,  C07C253/00

CPC分类号： C07C319/20 ,  C07C323/60 ,  C07C323/58 ,  C07C323/52

摘要： A method for the production of 2-hydroxy-4-(methylthio)butyronitrile having good storage stability in a multi-zone reactor, is provided. 3-methylmercaptopropionaldehyde is reacted with hydrogen cyanide in the presence of a base as catalyst in a main reaction zone of the multizone reactor to form a reaction mixture comprising the 2-hydroxy-4-(methylthio)butyronitrile, unreacted 3-methylmercaptopropionaldehyde, the catalyst and residual amounts of gaseous hydrogen cyanide. The residual gaseous hydrogen cyanide is removed from the main reaction zone to an absorption and post-reaction zone of the reactor which comprises a mixture of 3-methylmercaptopropionaldehyde and the catalyst; and the gaseous hydrogen cyanide is further reacted with the 3-methylmercaptopropionaldehyde in the absorption and post reaction zone. A molar ratio of hydrogen cyanide to 3-(methylthio)propanal in the main reaction zone is from 0.98 to 1.03.

摘要翻译： 提供了一种在多区域反应器中制备具有良好储存稳定性的2-羟基-4-（甲硫基）丁腈的方法。 在多基团反应器的主反应区中，3-甲基巯基丙醛与作为催化剂的碱存在下，与氰化氢反应形成包含2-羟基-4-（甲硫基）丁腈，未反应的3-甲基巯基丙醛，催化剂 和残留量的氰化氢气体。 将残留的气态氰化氢从主反应区移除到包含3-甲基巯基丙醛和催化剂的混合物的反应器的吸收和后反应区域; 并且氰化氢气体在吸收和后反应区域中与3-甲基巯基丙醛进一步反应。 主反应区氰化氢与3-（甲硫基）丙醛的摩尔比为0.98-1.03。

公开(公告)号：US09206121B2

公开(公告)日：2015-12-08

申请号：US14671435

申请日：2015-03-27

申请人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

发明人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

IPC分类号： C07C319/20 ,  C07C51/08 ,  C07C253/00

CPC分类号： C07C319/20 ,  C07C323/60 ,  C07C323/58 ,  C07C323/52

摘要： A method to produce D,L-Methionine from 2-hydroxy-4-(methylthio)butyronitrile by reaction with ammonia, optionally in the presence of carbon dioxide, is provided. The 2-hydroxy-4-(methylthio)butyronitrile is obtained by reaction of 3-methylmercaptopropionaldehyde with hydrogen cyanide in the presence of a base as catalyst in a main reaction zone of a multizone reactor. Residual gaseous hydrogen cyanide is removed from the main reaction zone to an absorption and post-reaction zone of the reactor which comprises a mixture of 3-methylmercaptopropionaldehyde and the catalyst; and the gaseous hydrogen cyanide is further reacted with the 3-methylmercaptopropionaldehyde in the absorption and post reaction zone. A molar ratio of hydrogen cyanide to 3-(methylthio)propanal in the main reaction zone is from 0.98 to 1.03.

摘要翻译： 提供了通过与氨反应，任选在二氧化碳存在下，由2-羟基-4-（甲硫基）丁腈生成D，L-甲硫氨酸的方法。 2-羟基-4-（甲硫基）丁腈通过3-甲基巯基丙醛与氰化氢在碱性作为催化剂存在下在多区反应器的主反应区中反应得到。 残留的气态氰化氢从主反应区除去反应器的吸收和后反应区，其包含3-甲基巯基丙醛和催化剂的混合物; 并且氰化氢气体在吸收和后反应区域中与3-甲基巯基丙醛进一步反应。 主反应区氰化氢与3-（甲硫基）丙醛的摩尔比为0.98-1.03。

公开(公告)号：US08729288B2

公开(公告)日：2014-05-20

申请号：US13402041

申请日：2012-02-22

申请人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

发明人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

IPC分类号： C07C253/00 ,  C07C51/08

CPC分类号： C07C319/20 ,  C07C323/60 ,  C07C323/58 ,  C07C323/52

摘要： A method for the production of 2-hydroxy-4-(methylthio)butyronitrile having good storage stability in a multi-zone reactor, is provided. 3-methylmercaptopropionaldehyde is reacted with hydrogen cyanide in the presence of a base as catalyst in a main reaction zone of the multizone reactor to form a reaction mixture comprising the 2-hydroxy-4-(methylthio)butyronitrile, unreacted 3-methylmercaptopropionaldehyde, the catalyst and residual amounts of gaseous hydrogen cyanide. The residual gaseous hydrogen cyanide is removed from the main reaction zone to an absorption and post-reaction zone of the reactor which comprises a mixture of 3-methylmercaptopropionaldehyde and the catalyst; and the gaseous hydrogen cyanide is further reacted with the 3-methylmercaptopropionaldehyde in the absorption and post reaction zone. A molar ratio of hydrogen cyanide to 3-(methylthio)propanal in the main reaction zone is from 0.98 to 1.03.

摘要翻译： 提供了一种在多区域反应器中制备具有良好储存稳定性的2-羟基-4-（甲硫基）丁腈的方法。 在多基团反应器的主反应区中，3-甲基巯基丙醛与作为催化剂的碱存在下，与氰化氢反应形成包含2-羟基-4-（甲硫基）丁腈，未反应的3-甲基巯基丙醛，催化剂 和残留量的氰化氢气体。 将残留的气态氰化氢从主反应区移除到包含3-甲基巯基丙醛和催化剂的混合物的反应器的吸收和后反应区域; 并且氰化氢气体在吸收和后反应区域中与3-甲基巯基丙醛进一步反应。 主反应区氰化氢与3-（甲硫基）丙醛的摩尔比为0.98-1.03。

公开(公告)号：US08546601B2

公开(公告)日：2013-10-01

申请号：US13402032

申请日：2012-02-22

申请人： Dieter Buss ,  Martin Steurenthaler ,  Joachim Hans Hasselbach ,  Michael R. Rinner ,  Benjamin Fonfe ,  Martin Koerfer ,  Stephan Kretz

发明人： Dieter Buss ,  Martin Steurenthaler ,  Joachim Hans Hasselbach ,  Michael R. Rinner ,  Benjamin Fonfe ,  Martin Koerfer ,  Stephan Kretz

IPC分类号： C07C319/20 ,  C07C323/12 ,  C07C323/58

CPC分类号： C07C319/20 ,  C07C319/26 ,  C07C323/60 ,  C07C323/58 ,  C07C323/52

摘要： A storage stable mixture containing 86 to 97% by weight of 2-hydroxy-4-methylthiobutyronitrile, 2 to 14% by weight of water, 0.05 to 0.5% by weight of HCN and having a pH of 1 to 4, measured using a pH electrode at 23° C. is provided. A method to produce the storage stable mixture and its use in manufacture of DL-methionine or 2-hydroxy-4-methylthiobutyric acid is also provided.

摘要翻译： 含有86-97重量％的2-羟基-4-甲基硫代丁腈，2-14重量％水，0.05-0.5重量％HCN和pH为1-4的储存稳定的混合物，使用pH 提供23℃的电极。 还提供了制备储存稳定混合物的方法及其在制备DL-甲硫氨酸或2-羟基-4-甲硫基丁酸中的用途。

公开(公告)号：US20160145114A1

公开(公告)日：2016-05-26

申请号：US14896719

申请日：2014-05-21

申请人： Bernd GLÖCKLER ,  Martin STEFFAN ,  Martin STEURENTHALER ,  Thomas MÜLLER ,  Steffen KRILL ,  Martin KÖRFER ,  EVONIK DEGUSSA GMBH

发明人： Bernd Glockler ,  Martin Steffan ,  Martin Steurenthaler ,  Thomas Müller ,  Nicolas Rigot ,  Steffen Krill ,  Martin Körfer

IPC分类号： C01C3/02 ,  B01J19/00 ,  B01J19/24

CPC分类号： C01C3/0229 ,  B01J12/007 ,  B01J19/0026 ,  B01J19/006 ,  B01J19/2415 ,  B01J2219/00777 ,  B01J2219/24

摘要： The reaction tube comprises a cylindrical ceramic tube and a catalyst comprising platinum applied to the inner surface of the tube, wherein the reaction tube has fins on the inner surface which run in the longitudinal direction of the tube, extend into the interior space of the reaction tube and are coated with catalyst. The reaction tube is suitable for preparing hydrogen cyanide by reacting ammonia and at least one aliphatic hydrocarbon having 1 to 4 carbon atoms at a temperature of 1000 to 1400° C.

摘要翻译： 反应管包括圆柱形陶瓷管和包含铂的催化剂，其施加到管的内表面，其中反应管在内表面上具有在管的纵向方向上延伸的翅片，延伸到反应的内部空间 并用催化剂涂覆。 该反应管适用于在1000-1400℃的温度下使氨和至少一种具有1至4个碳原子的脂族烃反应制备氰化氢。

公开(公告)号：US20140213819A1

公开(公告)日：2014-07-31

申请号：US14227418

申请日：2014-03-27

申请人： Dieter BUSS ,  Martin STEURENTHALER ,  Michael R. RINNER ,  Stephan KRETZ ,  Hans Joachim HASSELBACH ,  Caspar-Heinrich FINKELDEI ,  Martin KOERFER ,  Pablo ZACCHI

发明人： Dieter BUSS ,  Martin STEURENTHALER ,  Michael R. RINNER ,  Stephan KRETZ ,  Hans Joachim HASSELBACH ,  Caspar-Heinrich FINKELDEI ,  Martin KOERFER ,  Pablo ZACCHI

IPC分类号： C07C319/20

CPC分类号： C07C319/20 ,  C07C323/60 ,  C07C323/58 ,  C07C323/52

摘要： A method for the production of 2-hydroxy-4-(methylthio)butyronitrile having good storage stability in a multi-zone reactor, is provided. 3-methylmercaptopropionaldehyde is reacted with hydrogen cyanide in the presence of a base as catalyst in a main reaction zone of the multizone reactor to form a reaction mixture comprising the 2-hydroxy-4-(methylthio)butyronitrile, unreacted 3-methylmercaptopropionaldehyde, the catalyst and residual amounts of gaseous hydrogen cyanide. The residual gaseous hydrogen cyanide is removed from the main reaction zone to an absorption and post-reaction zone of the reactor which comprises a mixture of 3-methylmercaptopropionaldehyde and the catalyst; and the gaseous hydrogen cyanide is further reacted with the 3-methylmercaptopropionaldehyde in the absorption and post reaction zone. A molar ratio of hydrogen cyanide to 3-(methylthio)propanal in the main reaction zone is from 0.98 to 1.03.

摘要翻译： 提供了一种在多区域反应器中制备具有良好储存稳定性的2-羟基-4-（甲硫基）丁腈的方法。 在多基团反应器的主反应区中，3-甲基巯基丙醛与作为催化剂的碱存在下，与氰化氢反应形成包含2-羟基-4-（甲硫基）丁腈，未反应的3-甲基巯基丙醛，催化剂 和残留量的氰化氢气体。 将残留的气态氰化氢从主反应区移除到包含3-甲基巯基丙醛和催化剂的混合物的反应器的吸收和后反应区域; 并且氰化氢气体在吸收和后反应区域中与3-甲基巯基丙醛进一步反应。 主反应区氰化氢与3-（甲硫基）丙醛的摩尔比为0.98-1.03。

公开(公告)号：US20120215021A1

公开(公告)日：2012-08-23

申请号：US13402032

申请日：2012-02-22

申请人： Dieter Buss ,  Martin Steurenthaler ,  Hans Joachim Hasselbach ,  Michael R. Rinner ,  Benjamin Fonfe ,  Martin Koerfer ,  Stephan Kretz

发明人： Dieter Buss ,  Martin Steurenthaler ,  Hans Joachim Hasselbach ,  Michael R. Rinner ,  Benjamin Fonfe ,  Martin Koerfer ,  Stephan Kretz

IPC分类号： C07C321/14 ,  C07C319/20

CPC分类号： C07C319/20 ,  C07C319/26 ,  C07C323/60 ,  C07C323/58 ,  C07C323/52

摘要： A storage stable mixture containing 86 to 97% by weight of 2-hydroxy-4-methylthiobutyronitrile, 2 to 14% by weight of water, 0.05 to 0.5% by weight of HCN and having a pH of 1 to 4, measured using a pH electrode at 23° C. is provided. A method to produce the storage stable mixture and its use in manufacture of DL-methionine or 2-hydroxy-4-methylthiobutyric acid is also provided.

摘要翻译： 含有86-97重量％的2-羟基-4-甲基硫代丁腈，2-14重量％的水，0.05-0.5重量％的HCN和pH为1-4的储存稳定的混合物，使用pH 提供23℃的电极。 还提供了制备储存稳定混合物的方法及其在制备DL-甲硫氨酸或2-羟基-4-甲硫基丁酸中的用途。