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    Therapy control based on a patient movement state
    1.
    发明授权
    Therapy control based on a patient movement state 有权
    基于患者运动状态的治疗控制

    公开(公告)号：US08554325B2

    公开(公告)日：2013-10-08

    申请号：US13345397

    申请日：2012-01-06

    Applicant: Gregory F. Molnar ,  Steven S. Gill ,  Keith A. Miesel ,  Mark S. Lent ,  Timothy J. Denison ,  Eric J. Panken ,  Carl D. Wahlstrand ,  Jonathan C. Werder

    Inventor： Gregory F. Molnar ,  Steven S. Gill ,  Keith A. Miesel ,  Mark S. Lent ,  Timothy J. Denison ,  Eric J. Panken ,  Carl D. Wahlstrand ,  Jonathan C. Werder

    IPC: A61N1/18

    CPC classification number: A61B5/04014 ,  A61B5/0006 ,  A61B5/4082 ,  A61B5/6814 ,  A61N1/36003 ,  A61N1/36014 ,  A61N1/36025 ,  A61N1/36067 ,  A61N1/36082

    Abstract: A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.

    Abstract translation: 基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。 在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。 运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。 在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。 在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。 此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

    Regional therapies for treatment of pain
    2.
    发明授权
    Regional therapies for treatment of pain 有权
    治疗疼痛的区域疗法

    公开(公告)号：US08244360B2

    公开(公告)日：2012-08-14

    申请号：US11374793

    申请日：2006-03-14

    Applicant: Kenneth T. Heruth ,  Mark S. Lent ,  Ruchika Singhal ,  Michael J. Schendel

    Inventor： Kenneth T. Heruth ,  Mark S. Lent ,  Ruchika Singhal ,  Michael J. Schendel

    IPC: A61N1/32

    CPC classification number: A61M5/14276 ,  A61M5/172 ,  A61M5/1723 ,  A61M2205/054 ,  A61M2205/3523 ,  A61N1/025 ,  A61N1/36071 ,  A61N1/372 ,  A61N1/37229

    Abstract: Systems and methods for coordinated delivery of a therapeutic agent and low (less than about 20 Hz) and high (greater than about 50 Hz) frequency stimulation therapy are described. The systems include a control unit for coordinating therapy delivery between an infusion device and a pulse generator, such that a therapeutic agent is administered at a predetermined time relative to application of either low frequency or high frequency stimulation. For example, the control unit may instruct the infusion device to deliver therapeutic agent at a predetermined time prior to delivery of low frequency stimulation. Systems that include more than one infusion device or an infusion pump capable of delivering more than one therapeutic agent are also described.

    Abstract translation: 描述了用于协调递送治疗剂和低（小于约20Hz）和高（大于约50Hz）频率刺激疗法的系统和方法。 该系统包括用于协调输注装置和脉冲发生器之间的治疗递送的控制单元，使得治疗剂在相对于低频或高频刺激的施加的预定时间被施用。 例如，控制单元可以在输送低频刺激之前的预定时间指示输注装置递送治疗剂。 还描述了包括多于一个输注装置或能够递送多于一种治疗剂的输注泵的系统。

    Implantable drug delivery systems and methods
    3.
    发明授权
    Implantable drug delivery systems and methods 有权
    可植入药物输送系统和方法

    公开(公告)号：US08216177B2

    公开(公告)日：2012-07-10

    申请号：US10746269

    申请日：2003-12-23

    Applicant: Kenneth T Heruth ,  Mark S Lent ,  Justin A Blanco

    Inventor： Kenneth T Heruth ,  Mark S Lent ,  Justin A Blanco

    IPC: A61M31/00

    CPC classification number: A61M5/14276 ,  A61M5/16827 ,  A61M25/007 ,  A61M2025/0007 ,  A61M2025/0057 ,  A61M2025/0073 ,  A61M2202/0464 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/128 ,  A61M2205/3331 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2210/0693 ,  A61M2210/1003

    Abstract: Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes that develop significant back pressure to enhance uniform delivery of the drug over an infusion section; catheters that have two or more infusion sections spaced apart along the length of the same catheter, catheters that include two or more infusion sections serviced by independent lumens (such that, e.g., different drug solutions can be delivered to the different infusion sections); implantable drug delivery systems with pumps and multiple reservoirs from which drugs can be delivered; systems that are capable of delivering drug solutions with selected densities; etc.

    Abstract translation: 公开了用于将一种或多种药物递送到一个或多个内部身体位置（例如脑脊液）的装置，系统和方法。 在各个方面，系统和方法可以包括具有渗透膜的输注部分的导管，其具有显着的背压以增强药物在输注部分上的均匀递送; 具有沿相同导管的长度间隔开的两个或更多个输注部分的导管，包括由独立管腔服务的两个或更多个输注部分的导管（使得例如不同的药物溶液可以被递送到不同的输注部分）; 具有泵和多个储存器的可植入药物递送系统，药物可以从其中递送; 能够递送选定密度的药物溶液的系统; 等等

    Peripheral Nerve Field Stimulation Control
    5.
    发明申请
    Peripheral Nerve Field Stimulation Control 有权
    周边神经域刺激控制

    公开(公告)号：US20090281594A1

    公开(公告)日：2009-11-12

    申请号：US12359001

    申请日：2009-01-23

    Applicant: Gary W. King ,  Steven M. Goetz ,  Andrew H. Houchins ,  Jeffrey T. Keacher ,  Jordan J. Greenberg ,  Kenneth T. Heruth ,  Mark S. Lent ,  Paul W. Wacnik

    Inventor： Gary W. King ,  Steven M. Goetz ,  Andrew H. Houchins ,  Jeffrey T. Keacher ,  Jordan J. Greenberg ,  Kenneth T. Heruth ,  Mark S. Lent ,  Paul W. Wacnik

    IPC: A61N1/34

    CPC classification number: A61N1/36139 ,  A61N1/36057 ,  A61N1/36071

    Abstract: Peripheral nerve field stimulation (PNFS) may be controlled based on detected physiological effects of the PNFS, which may be an efferent response to the PNFS. In some examples, a closed-loop therapy system may include a sensing module that senses a physiological parameter of the patient, which may be indicative of the patient's response to the PNFS. Based on a signal generated by the sensing module, the PNFS may be activated, deactivated or modified. Example physiological parameters of the patient include heart rate, respiratory rate, electrodermal activity, muscle activity, blood flow rate, sweat gland activity, pilomotor reflex, or thermal activity of the patient's body. In some examples, a patient pain state may be detected based on a signal generated by the sensing module, and therapy may be controlled based on the detection of the pain state.

    Abstract translation: 可以基于PNFS的检测到的生理效应来控制外周神经区域刺激（PNFS），这可能是对PNFS的传出响应。 在一些示例中，闭环治疗系统可以包括感测患者的生理参数的感测模块，其可以指示患者对PNFS的反应。 基于由感测模块产生的信号，可以激活，去激活或修改PNFS。 患者的生理参数包括心率，呼吸频率，皮肤活动，肌肉活动，血流速度，汗腺活动，引导反射或患者身体的热活动。 在一些示例中，可以基于由感测模块生成的信号来检测患者疼痛状态，并且可以基于疼痛状态的检测来控制治疗。

    THERAPY CONTROL BASED ON A PATIENT MOVEMENT STATE
    6.
    发明申请
    THERAPY CONTROL BASED ON A PATIENT MOVEMENT STATE 有权
    基于患者运动状态的治疗控制

    公开(公告)号：US20090099627A1

    公开(公告)日：2009-04-16

    申请号：US12237799

    申请日：2008-09-25

    Applicant: Gregory F. Molnar ,  Steven S. Gill ,  Keith A. Miesel ,  Mark S. Lent ,  Timothy J. Denison ,  Eric J. Panken ,  Carl D. Wahlstrand ,  Jonathan C. Werder

    Inventor： Gregory F. Molnar ,  Steven S. Gill ,  Keith A. Miesel ,  Mark S. Lent ,  Timothy J. Denison ,  Eric J. Panken ,  Carl D. Wahlstrand ,  Jonathan C. Werder

    IPC: A61N1/36 ,  A61B5/0476 ,  A61M37/00

    CPC classification number: A61B5/04014 ,  A61B5/0006 ,  A61B5/4082 ,  A61B5/6814 ,  A61N1/36003 ,  A61N1/36014 ,  A61N1/36025 ,  A61N1/36067 ,  A61N1/36082

    Abstract: A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.

    Abstract translation: 基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。 在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。 运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。 在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。 在一些示例中，在检测到患者不再处于运动状态或患者已经成功启动运动时，治疗递送被停用。 此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

    Peripheral nerve field stimulation control
    7.
    发明授权
    Peripheral nerve field stimulation control 有权
    外周神经域刺激控制

    公开(公告)号：US08805518B2

    公开(公告)日：2014-08-12

    申请号：US12359001

    申请日：2009-01-23

    Applicant: Gary W. King ,  Steven M. Goetz ,  Andrew H. Houchins ,  Jeffrey T. Keacher ,  Jordan J. Greenberg ,  Kenneth T. Heruth ,  Mark S. Lent ,  Paul W. Wacnik

    Inventor： Gary W. King ,  Steven M. Goetz ,  Andrew H. Houchins ,  Jeffrey T. Keacher ,  Jordan J. Greenberg ,  Kenneth T. Heruth ,  Mark S. Lent ,  Paul W. Wacnik

    IPC: A61N1/34

    CPC classification number: A61N1/36139 ,  A61N1/36057 ,  A61N1/36071

    Abstract: Peripheral nerve field stimulation (PNFS) may be controlled based on detected physiological effects of the PNFS, which may be an efferent response to the PNFS. In some examples, a closed-loop therapy system may include a sensing module that senses a physiological parameter of the patient, which may be indicative of the patient's response to the PNFS. Based on a signal generated by the sensing module, the PNFS may be activated, deactivated or modified. Example physiological parameters of the patient include heart rate, respiratory rate, electrodermal activity, muscle activity, blood flow rate, sweat gland activity, pilomotor reflex, or thermal activity of the patient's body. In some examples, a patient pain state may be detected based on a signal generated by the sensing module, and therapy may be controlled based on the detection of the pain state.

    Abstract translation: 可以基于PNFS的检测到的生理效应来控制外周神经区域刺激（PNFS），这可能是对PNFS的传出响应。 在一些示例中，闭环治疗系统可以包括感测患者的生理参数的感测模块，其可以指示患者对PNFS的反应。 基于由感测模块产生的信号，可以激活，去激活或修改PNFS。 患者的生理参数包括心率，呼吸频率，皮肤活动，肌肉活动，血流速度，汗腺活动，引导反射或患者身体的热活动。 在一些示例中，可以基于由感测模块生成的信号来检测患者疼痛状态，并且可以基于疼痛状态的检测来控制治疗。

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