公开(公告)号：US20130203995A1

公开(公告)日：2013-08-08

申请号：US13519398

申请日：2011-01-04

Applicant: Alistair Boyd ,  Mark Richard Fielding ,  James Gair Ford ,  Lianne Frodsham ,  Michael D. Golden ,  Kevin William Leslie ,  Ben Mckeever-Abbas ,  Paula Tomlin

Inventor： Alistair Boyd ,  Mark Richard Fielding ,  James Gair Ford ,  Lianne Frodsham ,  Michael D. Golden ,  Kevin William Leslie ,  Ben Mckeever-Abbas ,  Paula Tomlin

IPC: C07D413/10

CPC classification number: C07D413/10 ,  C07C235/42 ,  C07D209/46 ,  C07D307/68 ,  C07D307/88 ,  C07D413/04

Abstract: Processes for making 7-methyl-5-(3piperazin-1-ylmethyl-[1,2,4]oxadiazol-5-yl)-2-(4-trifluoromethoxybenzyl)-2,3-dihydroisoindol-1-one

Abstract translation: 制备7-甲基-5-（3-哌嗪-1-基甲基 - [1,2,4]恶二唑-5-基）-2-（4-三氟甲氧基苄基）-2,3-二氢异吲哚-1-酮的方法

公开(公告)号：US08299076B2

公开(公告)日：2012-10-30

申请号：US11914433

申请日：2006-05-17

Applicant: Allison L. Marlow ,  Eli Wallace ,  Jeongbeob Seo ,  Joseph P. Lyssikatos ,  Hong Woon Yang ,  Jim Blake ,  Richard Anthony Storey ,  Rebecca Jane Booth ,  John David Pittam ,  John Leonard ,  Mark Richard Fielding

Inventor： Allison L. Marlow ,  Eli Wallace ,  Jeongbeob Seo ,  Joseph P. Lyssikatos ,  Hong Woon Yang ,  Jim Blake ,  Richard Anthony Storey ,  Rebecca Jane Booth ,  John David Pittam ,  John Leonard ,  Mark Richard Fielding

IPC: A01N43/58 ,  A01N43/54 ,  A01N43/40 ,  C07D401/00 ,  C07D239/02 ,  C07D487/00 ,  A61P35/00 ,  A61P29/00

CPC classification number: C07D237/24 ,  C07D213/80 ,  C07D213/82 ,  C07D213/84 ,  C07D213/85

Abstract: Disclosed are crystalline forms of 2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

Abstract translation: 公开了可用于治疗过度增殖的2-（2-氟-4-碘苯基氨基）-N-（2-羟基乙氧基）-1,5-二甲基-6-氧代-1,6-二氢吡啶-3-甲酰胺的结晶形式 疾病，如癌症和炎症，哺乳动物和炎症病症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。

公开(公告)号：US20110015392A1

公开(公告)日：2011-01-20

申请号：US12854388

申请日：2010-08-11

Applicant: Mark Richard Fielding ,  John Leonard

Inventor： Mark Richard Fielding ,  John Leonard

IPC: C07D265/32 ,  C07D213/80

CPC classification number: C07D213/74 ,  C07D265/32

Abstract: A route for preparing a compound of formula (I) where X, R1, R2, R7, R8 and R9 are as defined in the specification, is described. Process steps used in the route and novel intermediates prepared during the route are also described and claimed. Compounds of formula (I) are used in the preparation of pharmaceutical compounds, in particular inhibitors of MEK, useful in the treatment of hyperproliferative disease such as cancer and inflammatory conditions.

Abstract translation: 描述了制备其中X，R 1，R 2，R 7，R 8和R 9如说明书中所定义的式（I）化合物的途径。 路线中使用的工艺步骤和在路线中制备的新型中间体也被描述和要求保护。 式（I）化合物用于制备药物化合物，特别是MEK抑制剂，其可用于治疗过度增殖性疾病如癌症和炎性病症。

公开(公告)号：US20080280957A1

公开(公告)日：2008-11-13

申请号：US11914433

申请日：2006-05-17

Applicant: Allison L. Marlow ,  Eli M. Wallace ,  Jeongbeob Seo ,  Joseph P. Lyssikatos ,  Hoog Woon Yang ,  James Blake ,  Richard Anthony Storey ,  Rebecca Jane Booth ,  John David Pittam ,  John Leonard ,  Mark Richard Fielding

Inventor： Allison L. Marlow ,  Eli M. Wallace ,  Jeongbeob Seo ,  Joseph P. Lyssikatos ,  Hoog Woon Yang ,  James Blake ,  Richard Anthony Storey ,  Rebecca Jane Booth ,  John David Pittam ,  John Leonard ,  Mark Richard Fielding

IPC: A61K31/4412 ,  C07D213/63 ,  A61P35/00

CPC classification number: C07D237/24 ,  C07D213/80 ,  C07D213/82 ,  C07D213/84 ,  C07D213/85

Abstract: Disclosed are MEK inhibitors useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

Abstract translation: 公开了可用于治疗哺乳动物和炎性病症中过度增殖性疾病如癌症和炎症的MEK抑制剂。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。