公开(公告)号：US20070087057A1

公开(公告)日：2007-04-19

申请号：US11610603

申请日：2006-12-14

Applicant: Leah Appel ,  Ronald Beyerinck ,  Mark Chidlaw ,  William Curatolo ,  Dwayne Friesen ,  Kelly Smith ,  Avinash Thombre

Inventor： Leah Appel ,  Ronald Beyerinck ,  Mark Chidlaw ,  William Curatolo ,  Dwayne Friesen ,  Kelly Smith ,  Avinash Thombre

IPC: A61K9/24

CPC classification number: A61K9/0004

Abstract: A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific drug release profiles are disclosed.

Abstract translation: 控释剂型具有涂覆的核心，其核心包含含药物的组合物和水溶胀性组合物，每个组合物占据核心内的分开的区域。 含药组合物包含低溶解度药物和药物引诱剂。 芯周围的涂层是透水的，不溶于水的，并且具有至少一个通过其的输送口。 公开了具有特定药物释放曲线的多种制剂。