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公开(公告)号：US08273794B2
公开(公告)日：2012-09-25
申请号：US11569004
申请日：2005-05-16
申请人： Maria Isabel Gomez-Orellana , David Gschneidner , Andrea Leone-Bay , Destardi Moye-Sherman , Stephen V. Pusztay , Parshuram Rath , Pingwah Tang , John J. Weidner , Jianfeng Song
发明人： Maria Isabel Gomez-Orellana , David Gschneidner , Andrea Leone-Bay , Destardi Moye-Sherman , Stephen V. Pusztay , Parshuram Rath , Pingwah Tang , John J. Weidner , Jianfeng Song
IPC分类号： A61K31/19 , A61K31/195 , C07C229/00
CPC分类号： C07C233/07 , A61K9/0031 , A61K9/0073 , A61K9/0095 , A61K9/2013 , A61K31/192 , A61K31/195 , A61K38/00 , A61K45/06 , A61K47/183 , C07C2601/14 , A61K2300/00
摘要： Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译： 提供用于递送活性剂的化合物和组合物。 也提供给药和制备方法。
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公开(公告)号：US09399054B2
公开(公告)日：2016-07-26
申请号：US11571862
申请日：2005-07-12
CPC分类号： A61K38/22 , A61K9/0056 , A61K9/2013 , A61K9/2072 , A61K9/2095
摘要： The present invention provides a composition (e.g., a pharmaceutical composition) comprising at least one delivery agent compound and at least one of peptide YY (PYY) and a PYY agonist. Preferably, the composition includes a therapeutically effective amount of peptide YY or the PYY agonist and the delivery agent compound. The composition of the present invention facilitates the delivery of PYY, a PYY agonist, or a mixture thereof and increases its bioavailability compared to administration without the delivery agent compound. PPY and PYY agonists possess activity as agents to reduce nutrient availability, including reduction of food intake.
摘要翻译： 本发明提供包含至少一种递送剂化合物和肽YY（PYY）和PYY激动剂中的至少一种的组合物（例如药物组合物）。 优选地，组合物包含治疗有效量的肽YY或PYY激动剂和递送剂化合物。 本发明的组合物有助于PYY，PYY激动剂或其混合物的递送，并且与不含递送剂化合物的给药相比，其生物利用度增加。 PPY和PYY激动剂具有作为减少营养物质可用性的药剂的活性，包括减少食物摄取量。
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公开(公告)号：US09035085B2
公开(公告)日：2015-05-19
申请号：US12045395
申请日：2008-03-10
IPC分类号： C07C303/00 , C07C233/33 , A61K31/192 , A61K45/06 , C07C59/90
CPC分类号： C07C233/33 , A61K31/19 , A61K31/192 , A61K31/727 , A61K38/2271 , A61K38/28 , A61K38/29 , A61K45/06 , C07C59/90 , Y02A50/406 , A61K2300/00
摘要： The present invention provides aryl ketone compounds and compositions containing them which facilitate the delivery of active agents. The aryl ketone compounds have the formula or a salt thereof, where n=1 to 9, and R1 to R5 are independently hydrogen, C1 to C4 alkyl, C1 to C4 alkoxy, C2 to C4 alkenyl, halogen, hydroxyl, —NH—C(O)—CH3, or —O—C6H5.
摘要翻译： 本发明提供芳基酮化合物和含有它们的组合物，其有利于递送活性剂。 芳基酮化合物具有下式或其盐，其中n = 1至9，并且R 1至R 5独立地为氢，C 1至C 4烷基，C 1至C 4烷氧基，C 2至C 4烯基，卤素，羟基，-NH-C （O）-CH 3或-O-C 6 H 5。
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公开(公告)号：US20080255250A1
公开(公告)日：2008-10-16
申请号：US11569004
申请日：2005-05-16
申请人： Maria Isabel Gomez-Orellana , David Gschneidner , Andrea Leone-Bay , Destardi Moye-Sherman , Stephen V. Pusztay , Parshuram Rath , Pingwah Tang , John J. Weidner , Jianfeng Song
发明人： Maria Isabel Gomez-Orellana , David Gschneidner , Andrea Leone-Bay , Destardi Moye-Sherman , Stephen V. Pusztay , Parshuram Rath , Pingwah Tang , John J. Weidner , Jianfeng Song
IPC分类号： A61K47/12 , A61K47/18 , C07C229/42
CPC分类号： C07C233/07 , A61K9/0031 , A61K9/0073 , A61K9/0095 , A61K9/2013 , A61K31/192 , A61K31/195 , A61K38/00 , A61K45/06 , A61K47/183 , C07C2601/14 , A61K2300/00
摘要： Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译： 提供用于递送活性剂的化合物和组合物。 也提供给药和制备方法。
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5.发明申请ARYL KETONE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS 审中-公开ARYL KETONE化合物和用于递送活性剂的组合物公开(公告)号：US20080167217A1
公开(公告)日：2008-07-10
申请号：US12045395
申请日：2008-03-10
IPC分类号： A61K31/715 , C07C59/00 , A61K31/19 , A61K31/70
CPC分类号： C07C233/33 , A61K31/19 , A61K31/192 , A61K31/727 , A61K38/2271 , A61K38/28 , A61K38/29 , A61K45/06 , C07C59/90 , Y02A50/406 , A61K2300/00
摘要： The present invention provides aryl ketone compounds and compositions containing them which facilitate the delivery of active agents. The aryl ketone compounds have the formula or a salt thereof, where n=1 to 9, and R1 to R5 are independently hydrogen, C1 to C4 alkyl, C1 to C4 alkoxy, C2 to C4 alkenyl, halogen, hydroxyl, —NH—C(O)—CH3, or —O—C6H5.
摘要翻译： 本发明提供芳基酮化合物和含有它们的组合物，其有利于递送活性剂。 芳基酮化合物具有式或其盐，其中n = 1至9，R 1至R 5独立地为氢，C 1〜 C 1至C 4烷基，C 1至C 4烷氧基，C 2至C 4 烯基，卤素，羟基，-NH-C（O）-CH 3或-OC 6 H 5。
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