公开(公告)号：US06787333B2

公开(公告)日：2004-09-07

申请号：US10272394

申请日：2002-10-15

Applicant: Margaret E. Callahan ,  Thomas M. Folks ,  Paul Sandstrom ,  Shambavi Subbarao ,  Jennifer Brown ,  Walid Heneine ,  William M. Switzer

Inventor： Margaret E. Callahan ,  Thomas M. Folks ,  Paul Sandstrom ,  Shambavi Subbarao ,  Jennifer Brown ,  Walid Heneine ,  William M. Switzer

IPC: C12Q106

CPC classification number: C07K14/005 ,  A61K48/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2740/17021 ,  C12N2740/17022 ,  C12N2740/17043

Abstract: The present invention comprises spumavirus isolated from humans. More specifically, the spumavirus of the present invention was isolated from humans who had exposure to nonhuman primates. Importantly, the spumavirus of the present invention or antibodies to the spumavirus can be used to detect the presence of spumavirus or antibodies in body fluids, for pathogenicity studies of related viruses, and as a vector for gene therapies. The spumavirus of the invention can also be used for treatment of conditions in humans due to the presence of rapidly dividing cells and for recombinant live virus vaccination.

Abstract translation: 本发明包括从人分离的真菌病毒。 更具体地，将本发明的真菌病毒与暴露于非人类灵长类动物的人分离。 重要的是，本发明的真菌病毒或针对该病毒的抗体可用于检测体液中的真菌病毒或抗体的存在，相关病毒的致病性研究以及用于基因治疗的载体。 由于存在快速分裂的细胞和重组活病毒疫苗接种，本发明的真菌病毒也可用于治疗人体中的病症。

公开(公告)号：US06492165B1

公开(公告)日：2002-12-10

申请号：US09692652

申请日：2000-10-19

Applicant: Margaret E. Callahan ,  Thomas M. Folks ,  Paul Sandstrom ,  Shambavi Subbarao ,  Jennifer Brown ,  Walid Heneine ,  William M. Switzer

Inventor： Margaret E. Callahan ,  Thomas M. Folks ,  Paul Sandstrom ,  Shambavi Subbarao ,  Jennifer Brown ,  Walid Heneine ,  William M. Switzer

IPC: C12N1500

CPC classification number: C07K14/005 ,  A61K48/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2740/17021 ,  C12N2740/17022 ,  C12N2740/17043

Abstract: The present invention comprises spumavirus isolated from humans. More specifically, the spumavirus of the present invention was isolated from humans who had exposure to nonhuman primates. Importantly, the spumavirus of the present invention or antibodies to the spumavirus can be used to detect the presence of spumavirus or antibodies in body fluids, for pathogenicity studies of related viruses, and as a vector for gene therapies. The spumavirus of the invention can also be used for treatment of conditions in humans due to the presence of rapidly dividing cells and for recombinant live virus vaccination.

Abstract translation: 本发明包括从人分离的真菌病毒。 更具体地，将本发明的真菌病毒与暴露于非人类灵长类动物的人分离。 重要的是，本发明的真菌病毒或针对该病毒的抗体可用于检测体液中的真菌病毒或抗体的存在，相关病毒的致病性研究以及用于基因治疗的载体。 由于存在快速分裂的细胞和重组活病毒疫苗接种，本发明的真菌病毒也可用于治疗人体中的病症。