-
公开(公告)号：US20130057828A1
公开(公告)日：2013-03-07
申请号：US13405809
申请日：2012-02-27
Applicant: Marc de Smet
Inventor： Marc de Smet
Abstract: A system and method for fundus imaging wherein selective illumination of a sector of the field of view of the fundus, using off-axis illumination, provides images of acceptable clarity, resolution, and size, with significantly reduced reflections, in a compact system. By rotating illumination around the optical axis, sectors of the fundus may be selectively and sequentially illuminated. An image of the entire field of view of the fundus is obtained by combining images, e.g. two or more half images, obtained within a single shutter exposure or capture period. An illumination system using LED light sources and a rotatable occluder provides for a lightweight, handheld and portable fundus imaging system. It may take the form of a fundus camera, a fundus imaging lens module for regular camera, or an adapter which couples to the standard lens of a camera to create a low cost fundus camera.
Abstract translation: 用于眼底成像的系统和方法，其中使用离轴照明的眼底视野的区域的选择性照明在紧凑的系统中以显着减小的反射提供可接受的清晰度，分辨率和尺寸的图像。 通过围绕光轴旋转照明，可以选择性地并顺序地照亮眼底的扇形。 通过组合图像获得眼底的整个视野的图像，例如， 在单个快门曝光或捕获周期内获得的两个或更多个半图像。 使用LED光源和可旋转闭塞器的照明系统提供轻量级，手持式和便携式眼底成像系统。 它可以采用眼底相机，用于常规相机的眼底成像镜头模块或耦合到相机的标准镜头的适配器的形式来创建低成本眼底照相机。
-
公开(公告)号：US20110300123A1
公开(公告)日：2011-12-08
申请号：US13097985
申请日：2011-04-29
Applicant: Steve PAKOLA , Marc DE SMET
Inventor： Steve PAKOLA , Marc DE SMET
CPC classification number: A61K38/484 , A61K45/06 , C12Y302/01023 , C12Y302/01035 , C12Y304/21007 , C12Y304/24007 , C12Y402/02004 , C12Y402/02005 , C12Y402/02019 , A61K2300/00
Abstract: A method of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject comprising contacting a vitreous and/or aqueous humor with a composition comprising a truncated form of plasmin comprising a catalytic domain of plasmin (TPCD). TPCDs include, but are not limited to, miniplasmin, microplasmin and derivatives and variants thereof. The methods of the invention can be used to reduce the viscosity of the vitreous, liquefy the vitreous, induce posterior vitreous detachment, reduce hemorrhagic blood from the eye, clear or reduce materials toxic to the eye, clear or reduce intraocular foreign substances from the eye, increase diffusion of a composition administered to an eye, reduce extraretinal neovascularization and any combinations thereof. The method can be used in the absence of, or as an adjunct to, vitrectomy.
Abstract translation: 治疗或预防受试者眼睛疾病或病症并发症的方法，包括使玻璃体和/或房水与包含纤维蛋白溶酶的催化结构域（TPCD）的截短形式的纤溶酶的组合物接触。 TPCD包括但不限于微型血小板，微量血浆及其衍生物和变体。 本发明的方法可用于降低玻璃体粘度，液化玻璃体，诱导玻璃体后脱离，减少眼睛出血血液，清除或减少眼睛有毒的物质，清除或减少眼内异物 增加施用于眼睛的组合物的扩散，减少外耳道新生血管形成及其任何组合。 该方法可用于玻璃体切除术的缺失或辅助。
-
公开(公告)号：US08383105B2
公开(公告)日：2013-02-26
申请号：US12951787
申请日：2010-11-22
Applicant: Steve Pakola , Marc De Smet
Inventor： Steve Pakola , Marc De Smet
CPC classification number: A61K38/484 , A61K45/06 , C12Y302/01023 , C12Y302/01035 , C12Y304/21007 , C12Y304/24007 , C12Y402/02004 , C12Y402/02005 , C12Y402/02019 , A61K2300/00
Abstract: A method of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject comprising contacting a vitreous and/or aqueous humor with a composition comprising a truncated form of plasmin comprising a catalytic domain of plasmin (TPCD). TPCDs include, but are not limited to, miniplasmin, microplasmin and derivatives and variants thereof. The methods of the invention can be used to reduce the viscosity of the vitreous, liquefy the vitreous, induce posterior vitreous detachment, reduce hemorrhagic blood from the eye, clear or reduce materials toxic to the eye, clear or reduce intraocular foreign substances from the eye, increase diffusion of a composition administered to an eye, reduce extraretinal neovascularization and any combinations thereof. The method can be used in the absence of, or as an adjunct to, vitrectomy.
-
公开(公告)号：US07547435B2
公开(公告)日：2009-06-16
申请号：US10729475
申请日：2003-12-05
Applicant: Steve Pakola , Marc De Smet
Inventor： Steve Pakola , Marc De Smet
CPC classification number: A61K38/484 , A61K45/06 , C12Y302/01023 , C12Y302/01035 , C12Y304/21007 , C12Y304/24007 , C12Y402/02004 , C12Y402/02005 , C12Y402/02019 , A61K2300/00
Abstract: Methods of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject, comprising contacting a vitreous and/or aqueous humor with a composition comprising a truncated form of plasmin comprising a catalytic domain of plasmin (TPCD) are disclosed. TPCDs include, but are not limited to, miniplasmin, microplasmin and derivatives and variants thereof. The methods of the invention can be used to reduce the viscosity of the vitreous, liquefy the vitreous, induce posterior vitreous detachment, reduce hemorrhagic blood from the eye, clear or reduce materials toxic to the eye, clear or reduce intraocular foreign substances from the eye, increase diffusion of a composition administered to an eye, reduce extraretinal neovascularization and any combinations thereof. The method can be used in the absence of, or as an adjunct to, vitrectomy.
Abstract translation: 包括使玻璃体和/或房水与包含纤溶酶（TPCD）的催化结构域的截短形式的纤溶酶的组合物接触的方法，所述方法包括使玻璃体和/或房室液体接触， 披露 TPCD包括但不限于微型血小板，微量血浆及其衍生物和变体。 本发明的方法可用于降低玻璃体的粘度，使玻璃体液化，诱导玻璃体后脱离，减少眼睛出血，清除或减少对眼睛有毒的物质，清除或减少眼内异物 增加施用于眼睛的组合物的扩散，减少外耳道新生血管形成及其任何组合。 该方法可用于玻璃体切除术的缺失或辅助。
-
公开(公告)号：US20090081187A1
公开(公告)日：2009-03-26
申请号：US12156911
申请日：2008-06-05
Applicant: Steve Pakola , Marc De Smet
Inventor： Steve Pakola , Marc De Smet
CPC classification number: A61K38/484 , A61K45/06 , C12Y302/01023 , C12Y302/01035 , C12Y304/21007 , C12Y304/24007 , C12Y402/02004 , C12Y402/02005 , C12Y402/02019 , A61K2300/00
Abstract: A method of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject comprising contacting a vitreous and/or aqueous humor with a composition comprising a truncated form of plasmin comprising a catalytic domain of plasmin (TPCD). TPCDs include, but are not limited to, miniplasmin, microplasmin and derivatives and variants thereof. The methods of the invention can be used to reduce the viscosity of the vitreous, liquefy the vitreous, induce posterior vitreous detachment, reduce hemorrhagic blood from the eye, clear or reduce materials toxic to the eye, clear or reduce intraocular foreign substances from the eye, increase diffusion of a composition administered to an eye, reduce extraretinal neovascularization and any combinations thereof. The method can be used in the absence of, or as an adjunct to, vitrectomy.
Abstract translation: 治疗或预防受试者眼睛疾病或病症并发症的方法，包括使玻璃体和/或房水与包含纤维蛋白溶酶的催化结构域（TPCD）的截短形式的纤溶酶的组合物接触。 TPCD包括但不限于微型血小板，微量血浆及其衍生物和变体。 本发明的方法可用于降低玻璃体粘度，液化玻璃体，诱导玻璃体后脱离，减少眼睛出血血液，清除或减少眼睛有毒的物质，清除或减少眼内异物 增加施用于眼睛的组合物的扩散，减少外耳道新生血管形成及其任何组合。 该方法可用于玻璃体切除术的缺失或辅助。
-
Patent Agency Ranking
公开(公告)号：US20080095753A1
公开(公告)日：2008-04-24
申请号：US11786354
申请日：2007-04-11
Applicant: Steve Pakola , Marc De Smet
Inventor： Steve Pakola , Marc De Smet
CPC classification number: A61K38/484 , A61K45/06 , C12Y302/01023 , C12Y302/01035 , C12Y304/21007 , C12Y304/24007 , C12Y402/02004 , C12Y402/02005 , C12Y402/02019 , A61K2300/00
Abstract: Methods of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject, comprising contacting a vitreous and/or aqueous humor with a composition comprising a truncated form of plasmin comprising a catalytic domain of plasmin (TPCD) are disclosed. TPCDs include, but are not limited to, miniplasmin, microplasmin and derivatives and variants thereof. The methods of the invention can be used to reduce the viscosity of the vitreous, liquefy the vitreous, induce posterior vitreous detachment, reduce hemorrhagic blood from the eye, clear or reduce materials toxic to the eye, clear or reduce intraocular foreign substances from the eye, increase diffusion of a composition administered to an eye, reduce extraretinal neovascularization and any combinations thereof. The method can be used in the absence of, or as an adjunct to, vitrectomy.
Abstract translation: 包括使玻璃体和/或房水与包含纤溶酶（TPCD）的催化结构域的截短形式的纤溶酶的组合物接触的方法，所述方法包括使玻璃体和/或房室液体接触， 披露 TPCD包括但不限于微型血小板，微量血浆及其衍生物和变体。 本发明的方法可用于降低玻璃体粘度，液化玻璃体，诱导玻璃体后脱离，减少眼睛出血血液，清除或减少眼睛有毒的物质，清除或减少眼内异物 增加施用于眼睛的组合物的扩散，减少外耳道新生血管形成及其任何组合。 该方法可用于玻璃体切除术的缺失或辅助。
-
公开(公告)号：US07914783B2
公开(公告)日：2011-03-29
申请号：US11786354
申请日：2007-04-11
Applicant: Steve Pakola , Marc De Smet
Inventor： Steve Pakola , Marc De Smet
CPC classification number: A61K38/484 , A61K45/06 , C12Y302/01023 , C12Y302/01035 , C12Y304/21007 , C12Y304/24007 , C12Y402/02004 , C12Y402/02005 , C12Y402/02019 , A61K2300/00
Abstract: Methods of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject, comprising contacting a vitreous and/or aqueous humor with a composition comprising a truncated form of plasmin comprising a catalytic domain of plasmin (TPCD) are disclosed. TPCDs include, but are not limited to, miniplasmin, microplasmin and derivatives and variants thereof. The methods of the invention can be used to reduce the viscosity of the vitreous, liquefy the vitreous, induce posterior vitreous detachment, reduce hemorrhagic blood from the eye, clear or reduce materials toxic to the eye, clear or reduce intraocular foreign substances from the eye, increase diffusion of a composition administered to an eye, reduce extraretinal neovascularization and any combinations thereof. The method can be used in the absence of, or as an adjunct to, vitrectomy.
Abstract translation: 包括使玻璃体和/或房水与包含纤溶酶（TPCD）的催化结构域的截短形式的纤溶酶的组合物接触的方法，所述方法包括使玻璃体和/或房室液体接触， 披露 TPCD包括但不限于微型血小板，微量血浆及其衍生物和变体。 本发明的方法可用于降低玻璃体粘度，液化玻璃体，诱导玻璃体后脱离，减少眼睛出血血液，清除或减少眼睛有毒的物质，清除或减少眼内异物 增加施用于眼睛的组合物的扩散，减少外耳道新生血管形成及其任何组合。 该方法可用于玻璃体切除术的缺失或辅助。
-
公开(公告)号：US20090074739A1
公开(公告)日：2009-03-19
申请号：US12156907
申请日：2008-06-05
Applicant: Steve Pakola , Marc De Smet
Inventor： Steve Pakola , Marc De Smet
CPC classification number: A61K38/484 , A61K45/06 , C12Y302/01023 , C12Y302/01035 , C12Y304/21007 , C12Y304/24007 , C12Y402/02004 , C12Y402/02005 , C12Y402/02019 , A61K2300/00
Abstract: A method of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject comprising contacting a vitreous and/or aqueous humor with a composition comprising a truncated form of plasmin comprising a catalytic domain of plasmin (TPCD). TPCDs include, but are not limited to, miniplasmin, microplasmin and derivatives and variants thereof. The methods of the invention can be used to reduce the viscosity of the vitreous, liquefy the vitreous, induce posterior vitreous detachment, reduce hemorrhagic blood from the eye, clear or reduce materials toxic to the eye, clear or reduce intraocular foreign substances from the eye, increase diffusion of a composition administered to an eye, reduce extraretinal neovascularization and any combinations thereof. The method can be used in the absence of, or as an adjunct to, vitrectomy.
-
公开(公告)号：US20050118158A1
公开(公告)日：2005-06-02
申请号：US10729475
申请日：2003-12-05
Applicant: Steve Pakola , Marc De Smet
Inventor： Steve Pakola , Marc De Smet
CPC classification number: A61K38/484 , A61K45/06 , C12Y302/01023 , C12Y302/01035 , C12Y304/21007 , C12Y304/24007 , C12Y402/02004 , C12Y402/02005 , C12Y402/02019 , A61K2300/00
Abstract: A method of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject comprising contacting a vitreous and/or aqueous humor with a composition comprising a truncated form of plasmin comprising a catalytic domain of plasmin (TPCD). TPCDs include, but are not limited to, miniplasmin, microplasmin and derivatives and variants thereof. The methods of the invention can be used to reduce the viscosity of the vitreous, liquefy the vitreous, induce posterior vitreous detachment, reduce hemorrhagic blood from the eye, clear or reduce materials toxic to the eye, clear or reduce intraocular foreign substances from the eye, increase diffusion of a composition administered to an eye, reduce extraretinal neovascularization and any combinations thereof. The method can be used in the absence of, or as an adjunct to, vitrectomy.
Abstract translation: 治疗或预防受试者眼睛疾病或病症并发症的方法，包括使玻璃体和/或房水与包含纤维蛋白溶酶的催化结构域（TPCD）的截短形式的纤溶酶的组合物接触。 TPCD包括但不限于微型血小板，微量血浆及其衍生物和变体。 本发明的方法可用于降低玻璃体粘度，液化玻璃体，诱导玻璃体后脱离，减少眼睛出血血液，清除或减少眼睛有毒的物质，清除或减少眼内异物 增加施用于眼睛的组合物的扩散，减少外耳道新生血管形成及其任何组合。 该方法可用于玻璃体切除术的缺失或辅助。
-
公开(公告)号：US08747842B2
公开(公告)日：2014-06-10
申请号：US13097985
申请日：2011-04-29
Applicant: Steve Pakola , Marc De Smet
Inventor： Steve Pakola , Marc De Smet
CPC classification number: A61K38/484 , A61K45/06 , C12Y302/01023 , C12Y302/01035 , C12Y304/21007 , C12Y304/24007 , C12Y402/02004 , C12Y402/02005 , C12Y402/02019 , A61K2300/00
Abstract: A method of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject comprising contacting a vitreous and/or aqueous humor with a composition comprising a truncated form of plasmin comprising a catalytic domain of plasmin (TPCD). TPCDs include, but are not limited to, miniplasmin, microplasmin and derivatives and variants thereof. The methods of the invention can be used to reduce the viscosity of the vitreous, liquefy the vitreous, induce posterior vitreous detachment, reduce hemorrhagic blood from the eye, clear or reduce materials toxic to the eye, clear or reduce intraocular foreign substances from the eye, increase diffusion of a composition administered to an eye, reduce extraretinal neovascularization and any combinations thereof. The method can be used in the absence of, or as an adjunct to, vitrectomy.
Abstract translation: 治疗或预防受试者眼睛疾病或病症并发症的方法，包括使玻璃体和/或房水与包含纤维蛋白溶酶的催化结构域（TPCD）的截短形式的纤溶酶的组合物接触。 TPCD包括但不限于微型血小板，微量血浆及其衍生物和变体。 本发明的方法可用于降低玻璃体粘度，液化玻璃体，诱导玻璃体后脱离，减少眼睛出血血液，清除或减少眼睛有毒的物质，清除或减少眼内异物 增加施用于眼睛的组合物的扩散，减少外耳道新生血管形成及其任何组合。 该方法可用于玻璃体切除术的缺失或辅助。
-
-
-
-
-
-
-
-
-
Search Results
15
records
(took 0.022 seconds)
