公开(公告)号：US20210171957A1

公开(公告)日：2021-06-10

申请号：US17079380

申请日：2020-10-23

申请人： MICROCURES, INC.

发明人： Abhinav DEY ,  David James Sharp

IPC分类号： C12N15/113 ,  A61K9/00 ,  A61K35/17 ,  A61P35/00 ,  C12N5/0783

摘要： Methods are described for enhancing the tumor homing or penetration activity of T-cells to improve cancer treatment, by exposing T-cells in vitro, ex vivo or in vivo to an agent that inhibits fidgetin-like 2 activity, such as by using an RNA interference agent.

公开(公告)号：US20200289394A1

公开(公告)日：2020-09-17

申请号：US16768398

申请日：2018-10-23

申请人： MICROCURES, INC.

发明人： Brian O'ROURKE

IPC分类号： A61K8/60 ,  A61K31/712 ,  A61K8/46 ,  A61K8/73

摘要： The disclosure provides methods of enhancing hair growth and hair follicle restoration using a siRNA or shRNA directed against a human Fidgetin like-2 nucleic acid. Specifically, the disclosure provides compositions comprising siRNA or shRNA against a human Fidgetin like-2 nucleic acid, and the methods of using the compositions. Further disclosed are siRNA sequences against a human Fidgetin like-2 nucleic acid and the formulations of the compositions.

公开(公告)号：US20240294918A1

公开(公告)日：2024-09-05

申请号：US17802916

申请日：2021-02-27

申请人： MICROCURES, INC.

发明人： Douglas G. BROOKS ,  Brian O'ROURKE ,  Adam KRAMER ,  David James SHARP

IPC分类号： C12N15/113 ,  A61K9/107 ,  A61K9/70 ,  A61K47/06 ,  A61K47/10 ,  A61K47/20 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  A61P17/02

CPC分类号： C12N15/1137 ,  A61K9/1075 ,  A61K9/7007 ,  A61K47/06 ,  A61K47/10 ,  A61K47/20 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  A61P17/02 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321

摘要： Nucleic acid molecules and compositions thereof targeted to fidgetin-like 2, and methods of their use in treating a wound or scar in a human subject are described.

公开(公告)号：US20200338111A1

公开(公告)日：2020-10-29

申请号：US16758323

申请日：2018-10-16

申请人： MICROCURES, INC.

发明人： Brian O'ROURKE

IPC分类号： A61K31/7105 ,  A61B18/20 ,  A61N5/06 ,  A61K8/60 ,  A61K9/00 ,  A61K47/36 ,  A61K47/32 ,  A61P17/02 ,  A61Q19/08 ,  C12N15/113

摘要： Methods of enhancing skin health recovery from a skin procedure comprising laser application to the skin using a siRNA or shRNA directed against a human Fidgetin like-2 nucleic acid.

公开(公告)号：US20230263820A1

公开(公告)日：2023-08-24

申请号：US17963962

申请日：2022-10-11

申请人： MICROCURES, INC.

发明人： Brian O'Rourke

IPC分类号： A61K31/7105 ,  A61P17/02 ,  A61B18/20 ,  A61K8/60 ,  A61K9/00 ,  A61K47/32 ,  A61K47/36 ,  A61N5/06 ,  A61Q19/08 ,  C12N15/113

CPC分类号： A61K31/7105 ,  A61P17/02 ,  A61B18/203 ,  A61K8/606 ,  A61K9/0014 ,  A61K9/0021 ,  A61K47/32 ,  A61K47/36 ,  A61N5/0616 ,  A61Q19/08 ,  C12N15/1137 ,  A61B2018/00458

摘要： Methods of enhancing skin health recovery from a skin procedure comprising laser application to the skin using a siRNA or shRNA directed against a human Fidgetin like-2 nucleic acid.

公开(公告)号：US20230203495A1

公开(公告)日：2023-06-29

申请号：US17802905

申请日：2021-02-26

申请人： MICROCURES, INC.

发明人： David James SHARP ,  Brian O'ROURKE

IPC分类号： C12N15/113 ,  A61P17/02

CPC分类号： C12N15/1137 ,  A61P17/02 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/30

摘要： Methods of accelerating or improving the healing of a skin graft or skin grafting site in a subject are provided comprising administering to the subject an amount of an inhibitor of fidgetin-like 2.

公开(公告)号：US20210353824A1

公开(公告)日：2021-11-18

申请号：US17287910

申请日：2019-10-23

申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE ,  MICROCURES, INC.

发明人： David James SHARP ,  Brian O'ROURKE ,  Adam Hildyard KRAMER

IPC分类号： A61L26/00 ,  A61K8/02 ,  A61K8/60 ,  A61K8/90 ,  A61K8/65

摘要： Methods and compositions for reducing a ratio of collagen III to collagen I in wounded skin, treating wounds and accelerating healing is provided with a surfactant polymer dressing comprising FL2 siRNA, collagen and a poloxamer.