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公开(公告)号：US08420834B2
公开(公告)日：2013-04-16
申请号：US12679494
申请日：2008-09-25
发明人： Luigi Villanova
IPC分类号： C07D493/18 , A61K36/282
CPC分类号： C07D493/18
摘要： Disclosed is a process for manufacturing crude Artemisinin comprising the extraction of Artemisia annua from plant material with carbon dioxide or water in a critical physical state such that after extraction, the solvent evaporates completely from the resulting extract.
摘要翻译： 公开了一种制造粗制青蒿素的方法，其包括用临界物理状态的二氧化碳或水从植物材料中提取青蒿，使得萃取后溶剂从所得萃取物中完全蒸发。
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公开(公告)号：US20100331553A1
公开(公告)日：2010-12-30
申请号：US12679494
申请日：2008-09-25
IPC分类号： C07D493/18
CPC分类号： C07D493/18
摘要： Disclosed is a process for manufacturing crude Artemisinin comprising the extraction of Artemisia annua from plant material with carbon dioxide or water in a critical physical state such that after extraction, the solvent evaporates completely from the resulting extract.
摘要翻译： 公开了一种制造粗制青蒿素的方法，其包括用临界物理状态的二氧化碳或水从植物材料中提取青蒿，使得萃取后溶剂从所得萃取物中完全蒸发。
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3.发明申请YOGHURT CONTAINING HYDROXYTYROSOL AND OTHER BIOPHENOLS WITH A PREVENTIVE NUTRITIONAL ACTIVITY BENEFICIAL TO HUMAN BEINGS 审中-公开含有羟基酪醇和其他具有预防营养活性的生物素的含有人类受益人公开(公告)号：US20100297330A1
公开(公告)日：2010-11-25
申请号：US12669621
申请日：2008-07-15
申请人： Luigi Villanova , Azzurra Villanova , Luciano Villanova , Alessandro Merendino , Gianluca Fasieloo , Felicia Cisale
发明人： Luigi Villanova , Azzurra Villanova , Luciano Villanova , Alessandro Merendino , Gianluca Fasieloo , Felicia Cisale
IPC分类号： A23C9/123
CPC分类号： A23C9/13
摘要： A yoghurt includes hydroxytyrosol as an additional component, so as to provide a healthy, natural food product with additional health-giving and beneficial characteristics, which in particular provides nutritional prevention against damage caused by oxidative stress, inflammation, angiogenesis and the related tumoral processes, cholesterol proliferation and atherosclerotic processes, and a general effect of nutritional prevention of aging.
摘要翻译： 酸奶包括羟基酪醇作为附加组分，以便提供健康的天然食品，其具有额外的健康和有益特征，其特别地提供营养物质防止由氧化应激，炎症，血管生成和相关的肿瘤过程引起的损伤， 胆固醇增殖和动脉粥样硬化过程，以及营养预防老化的一般作用。
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4.发明授权Process for the recovery of tyrosol and hydroxytyrosol from oil mill wastewaters and catalytic oxidation method in order to convert tyrosol in hydroxytyrosol 有权从油厂废水中回收酪醇和羟基酪醇的方法和催化氧化方法，以转化羟基酪醇中的酪醇公开(公告)号：US07427358B2
公开(公告)日：2008-09-23
申请号：US11197359
申请日：2005-08-05
CPC分类号： B01J31/165 , A23L33/105 , A61K8/347 , A61Q19/02 , B01J2231/70 , B01J2531/74 , C02F1/001 , C02F1/26 , C02F1/441 , C02F1/442 , C02F1/444 , C02F1/725 , C02F9/00 , C02F2103/322 , C07C37/009 , C07C37/60 , C07C39/11
摘要： A for preparing Tyrosol and/or Hydroxytyrosol from oil mill wastewaters.includes: a) Microfiltration (MF), Ultrafiltration (UF). Nanofiltration (NF) and Reverse Osmosis (RO) of the OMW; b) Separation of Tyrosol, Hydroxytyrosol and other phenolic compounds from the concentrated RO; c) Oxidation of the obtained Tyrosol to Hydroxytyrosol in the presence of methyl rhenium trioxide and of hydrogen peroxide in a protic solvent.
摘要翻译： A用于从油磨废水中制备Tyrosol和/或羟基酪氨酸。 包括：a）微滤（MF），超滤（UF）。 OMW的纳滤（NF）和反渗透（RO）; b）从浓缩的RO中分离出Tyrosol，羟基酪醇和其他酚类化合物; c）在甲基三氧化铼和过氧化氢的存在下，在质子溶剂中将所得Tyrosol氧化成羟基酪醇。
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5.发明申请PROCESS FOR THE RECOVERY OF TYROSOL AND HYDROXYTYROSOL FROM OIL MILL WASTEWATERS AND CATALYTIC OXIDATION METHOD IN ORDER TO CONVERT TYROSOL IN HYDROXYTYROSOL 审中-公开从石油化工废水中回收甲醇和羟基喹啉的方法和催化氧化方法在羟基吡咯烷酮中转化酪氨酸公开(公告)号：US20090023815A1
公开(公告)日：2009-01-22
申请号：US12120252
申请日：2008-05-14
IPC分类号： A61K31/05
CPC分类号： B01J31/165 , A23L33/105 , A61K8/347 , A61Q19/02 , B01J2231/70 , B01J2531/74 , C02F1/001 , C02F1/26 , C02F1/441 , C02F1/442 , C02F1/444 , C02F1/725 , C02F9/00 , C02F2103/322 , C07C37/009 , C07C37/60 , C07C39/11
摘要： A process for preparing Tyrosol and/or Hydroxytyrosol from oil mill wastewaters. includes: a) Microfiltration (MF), Ultrafiltration (UF), Nanofiltration (NF) and Reverse Osmosis (RO) of the OMW; b) Separation of Tyrosol, Hydroxytyrosol and other phenolic compounds from the concentrated RO; c) Oxidation of the obtained Tyrosol to Hydroxytyrosol in the presence of methyl rhenium trioxide and of hydrogen peroxide in a protic solvent.
摘要翻译： 从油厂废水中制备Tyrosol和/或羟基酪醇的方法。 包括：a）OMW的微滤（MF），超滤（UF），纳滤（NF）和反渗透（RO）; b）从浓缩的RO中分离出Tyrosol，羟基酪醇和其他酚类化合物; c）在甲基三氧化铼和过氧化氢的存在下，在质子溶剂中将所得Tyrosol氧化成羟基酪醇。
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6.发明申请Process for the recovery of tyrosol and hydroxytyrosol from oil mill wastewaters and catalytic oxidation method in order to convert tyrosol in hydroxytyrosol 有权从油厂废水中回收酪醇和羟基酪醇的方法和催化氧化方法，以转化羟基酪醇中的酪醇公开(公告)号：US20060070953A1
公开(公告)日：2006-04-06
申请号：US11197359
申请日：2005-08-05
IPC分类号： B01D61/58 , C07C229/00
CPC分类号： B01J31/165 , A23L33/105 , A61K8/347 , A61Q19/02 , B01J2231/70 , B01J2531/74 , C02F1/001 , C02F1/26 , C02F1/441 , C02F1/442 , C02F1/444 , C02F1/725 , C02F9/00 , C02F2103/322 , C07C37/009 , C07C37/60 , C07C39/11
摘要： A for preparing Tyrosol and/or Hydroxytyrosol from oil mill wastewaters. includes: a) Microfiltration (MF), Ultrafiltration (UF), Nanofiltration (NF) and Reverse Osmosis (RO) of the OMW; b) Separation of Tyrosol, Hydroxytyrosol and other phenolic compounds from the concentrated RO; c) Oxidation of the obtained Tyrosol to Hydroxytyrosol in the presence of methyl rhenium trioxide and of hydrogen peroxide in a protic solvent.
摘要翻译： A用于从油磨废水中制备Tyrosol和/或羟基酪氨酸。 包括：a）OMW的微滤（MF），超滤（UF），纳滤（NF）和反渗透（RO）; b）从浓缩的RO中分离出Tyrosol，羟基酪醇和其他酚类化合物; c）在甲基三氧化铼和过氧化氢的存在下，在质子溶剂中将所得Tyrosol氧化成羟基酪醇。
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公开(公告)号：US08507698B2
公开(公告)日：2013-08-13
申请号：US12679916
申请日：2008-09-25
IPC分类号： C07D309/00 , A61K31/335
CPC分类号： C07D493/18
摘要： The invention relates to Artemisinin derivatives of general formula (I) wherein A and B are as defined in the specification. Compounds (I) have proved able to inhibit cell proliferation, in particular of uveal melanoma cells, and can therefore be used, either alone or in association with other antitumoral drugs, for the preparation of medicaments intended for the treatment of malignant melanoma.
摘要翻译： 本发明涉及通式（I）的青蒿素衍生物，其中A和B如说明书中所定义。 化合物（I）已经证明能够抑制细胞增殖，特别是葡萄膜黑素瘤细胞的增殖，因此可以单独使用或与其他抗肿瘤药物联合用于制备用于治疗恶性黑素瘤的药物。
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公开(公告)号：US20100216869A1
公开(公告)日：2010-08-26
申请号：US12679916
申请日：2008-09-25
IPC分类号： A61K31/335 , C07D323/00 , A61P35/00
CPC分类号： C07D493/18
摘要： The invention relates to Artemisinin derivatives of general formula (I) wherein A and B are as defined in the specification. Compounds (I) have proved able to inhibit cell proliferation, in particular of uveal melanoma cells, and can therefore be used, either alone or in association with other antitumoral drugs, for the preparation of medicaments intended for the treatment of malignant melanoma.
摘要翻译： 本发明涉及通式（I）的青蒿素衍生物，其中A和B如说明书中所定义。 化合物（I）已经证明能够抑制细胞增殖，特别是葡萄膜黑素瘤细胞的增殖，因此可以单独使用或与其他抗肿瘤药物联合用于制备用于治疗恶性黑素瘤的药物。
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