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1.发明授权公开(公告)号：US08658674B2
公开(公告)日：2014-02-25
申请号：US13571659
申请日：2012-08-10
申请人： Laval Chan Chun Kong , Sanjoy Kumar Das , Carl Poisson , Constantin G. Yannopoulos , Guy Falardeau , Louis Vaillancourt , Real Denis
发明人： Laval Chan Chun Kong , Sanjoy Kumar Das , Carl Poisson , Constantin G. Yannopoulos , Guy Falardeau , Louis Vaillancourt , Real Denis
IPC分类号： A61K31/4453 , C07D409/12
CPC分类号： C07F7/0812 , A61K38/005 , A61K38/21 , C07D333/38 , C07D333/40 , C07D409/12 , A61K2300/00
摘要： Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections.
摘要翻译： 由式I表示的化合物或其药学上可接受的盐和溶剂化物，其中R1，X，Y和Z如本文所定义，可用于治疗黄病毒科病毒感染。
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公开(公告)号：US08124613B2
公开(公告)日：2012-02-28
申请号：US12304685
申请日：2007-06-14
申请人： Christophe Moinet , Charles Blais , Monica Bubenik , Laval Chan Chun Kong , Marc Courchesne , Oswy Z. Pereira , Réal Denis , Louis Vaillancourt , Constantin G. Yannopoulos
发明人： Christophe Moinet , Charles Blais , Monica Bubenik , Laval Chan Chun Kong , Marc Courchesne , Oswy Z. Pereira , Réal Denis , Louis Vaillancourt , Constantin G. Yannopoulos
IPC分类号： A61K31/44 , C07D401/00
CPC分类号： C07D471/20
摘要： Compounds according to formula (I): wherein R1, R2, R3, n and X are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity. Additionally, compounds according to Formula III: wherein Z, R′1, and R′2 are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful as intermediates for production of compounds that modulate CCR5 chemokine receptor activity.
摘要翻译： 根据式（I）的化合物：其中R 1，R 2，R 3，n和X如本文所定义，其药学上可接受的盐，水合物和溶剂合物可用于调节CCR5趋化因子受体活性。 另外，根据式III的化合物：其中Z，R'1和R'2如本文所定义，其药学上可接受的盐，水合物和溶剂合物可用作产生调节CCR5趋化因子受体活性的化合物的中间体 。
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3.发明授权公开(公告)号：US08003685B2
公开(公告)日：2011-08-23
申请号：US11984330
申请日：2007-11-15
申请人： Laval Chan Chun Kong , Sanjoy Kumar Das , Carl Poisson , Constantin G. Yannopoulos , Guy Falardeau , Louis Vaillancourt , Réal Denis
发明人： Laval Chan Chun Kong , Sanjoy Kumar Das , Carl Poisson , Constantin G. Yannopoulos , Guy Falardeau , Louis Vaillancourt , Réal Denis
IPC分类号： A61K31/381 , C07D333/36
CPC分类号： C07F7/0812 , A61K38/005 , A61K38/21 , C07D333/38 , C07D333/40 , C07D409/12 , A61K2300/00
摘要： Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections.
摘要翻译： 由式I表示的化合物或其药学上可接受的盐和溶剂化物，其中R1，X，Y和Z如本文所定义，可用于治疗黄病毒科病毒感染。
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公开(公告)号：US20110105546A1
公开(公告)日：2011-05-05
申请号：US12304685
申请日：2007-06-14
申请人： Christophe Moinet , Charles Blas , Monica Bubenik , Laval Chan Chun Kong , Marc Courchesne , Oswy Pereira , Réal Denis , Louis Vaillancourt , Constantin Yannopoulos
发明人： Christophe Moinet , Charles Blas , Monica Bubenik , Laval Chan Chun Kong , Marc Courchesne , Oswy Pereira , Réal Denis , Louis Vaillancourt , Constantin Yannopoulos
IPC分类号： A61K31/46 , C07D451/00 , A61P31/18 , A61P29/00
CPC分类号： C07D471/20
摘要： Compounds according to formula (I): wherein R1, R2, R3, n and X are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity. Additionally, compounds according to Formula III: wherein Z, R′1, and R′2 are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful as intermediates for production of compounds that modulate CCR5 chemokine receptor activity.
摘要翻译： 根据式（I）的化合物：其中R 1，R 2，R 3，n和X如本文所定义，其药学上可接受的盐，水合物和溶剂合物可用于调节CCR5趋化因子受体活性。 另外，根据式III的化合物：其中Z，R'1和R'2如本文所定义，其药学上可接受的盐，水合物和溶剂合物可用作产生调节CCR5趋化因子受体活性的化合物的中间体 。
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5.发明申请Spirohydantoin compounds and methods for the modulation of chemokine receptor activity 失效螺乙内酰脲化合物和调节趋化因子受体活性的方法公开(公告)号：US20060014769A1
公开(公告)日：2006-01-19
申请号：US11159406
申请日：2005-06-23
IPC分类号： A61K31/4747 , C07D487/10
CPC分类号： C07D471/10
摘要： Novel compounds represented by formula (I): wherein R1, R2, R3 and R4 are as defined herein, and pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.
摘要翻译： 由式（I）表示的新型化合物：其中R 1，R 2，R 3和R 4均为 如本文所定义，及其药学上可接受的盐，水合物和溶剂化物，可用于调节CCR5趋化因子受体活性。
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公开(公告)号：US20120301430A1
公开(公告)日：2012-11-29
申请号：US13571659
申请日：2012-08-10
申请人： Laval Chan Chun Kong , Sanjoy Kumar Das , Carl Poisson , Constantin G. Yannopoulos , Guy Falardeau , Louis Vaillancourt , Real Denis
发明人： Laval Chan Chun Kong , Sanjoy Kumar Das , Carl Poisson , Constantin G. Yannopoulos , Guy Falardeau , Louis Vaillancourt , Real Denis
IPC分类号： A61K31/381 , C07D409/12 , A61K31/4192 , A61K31/4535 , A61K31/4196 , A61P37/02 , A61P39/06 , A61P31/04 , A61P37/04 , A61K39/00 , A61P1/16 , A61K31/7088 , A61P31/14 , A61P31/12 , A61K38/21 , A61K31/7056 , C07F7/10 , C07D333/38
CPC分类号： C07F7/0812 , A61K38/005 , A61K38/21 , C07D333/38 , C07D333/40 , C07D409/12 , A61K2300/00
摘要： Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections.
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7.发明授权公开(公告)号：US08269014B2
公开(公告)日：2012-09-18
申请号：US13172477
申请日：2011-06-29
申请人： Laval Chan Chun Kong , Sanjoy Kumar Das , Carl Poisson , Constantin G. Yannopoulos , Guy Falardeau , Louis Vaillancourt , Real Denis
发明人： Laval Chan Chun Kong , Sanjoy Kumar Das , Carl Poisson , Constantin G. Yannopoulos , Guy Falardeau , Louis Vaillancourt , Real Denis
IPC分类号： C07D409/12
CPC分类号： C07F7/0812 , A61K38/005 , A61K38/21 , C07D333/38 , C07D333/40 , C07D409/12 , A61K2300/00
摘要： Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections.
摘要翻译： 由式I表示的化合物或其药学上可接受的盐和溶剂化物，其中R1，X，Y和Z如本文所定义，可用于治疗黄病毒科病毒感染。
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8.发明申请BENZIMIDAZOLE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS 失效用于治疗或预防感染病毒的苯唑咪唑类似物公开(公告)号：US20110172238A1
公开(公告)日：2011-07-14
申请号：US12838350
申请日：2010-07-16
申请人： James A. Henderson , John Maxwell , Louis Vaillancourt , Mark Morris , Ronald Grey, JR. , Simon Giroux , Laval Chan Chun Kong , Sanjoy Kumar Das , Bingcan Liu , Carl Poisson , Caroline Cadilhac , Monica Bubenik , T. Jagadeeswar Reddy , Guy Falardeau , Constantin Yannopoulos , Jian Wang , Oswy Z. Pereira , Youssef L. Bennani , Albert C. Pierce , Govinda Rao Bhisetti , Kevin M. Cottrell , Valerie Marone
发明人： James A. Henderson , John Maxwell , Louis Vaillancourt , Mark Morris , Ronald Grey, JR. , Simon Giroux , Laval Chan Chun Kong , Sanjoy Kumar Das , Bingcan Liu , Carl Poisson , Caroline Cadilhac , Monica Bubenik , T. Jagadeeswar Reddy , Guy Falardeau , Constantin Yannopoulos , Jian Wang , Oswy Z. Pereira , Youssef L. Bennani , Albert C. Pierce , Govinda Rao Bhisetti , Kevin M. Cottrell , Valerie Marone
IPC分类号： A61K31/496 , C07D403/14 , A61K31/4184 , C07D401/14 , A61K31/4545 , A61K31/506 , A61K31/4439 , A61P31/14
CPC分类号： C07K5/06052 , C07D401/14 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D495/04
摘要： Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B′, X, Y, R1, R1′, R2, R2′, R3, R3′, R5, R5′, R6, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.
摘要翻译： 其中A，B，B'，X，Y，R1，R1'，R2，R2'，R3，R3'，R5，R5'，R6，m， n或p如本文所定义，可用于治疗黄病毒科病毒感染。
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9.发明申请Novel Spirotropane Compounds and Methods for the Modulation of Chemokine Receptor Activity 失效新型Spirotropane化合物和调节趋化因子受体活性的方法公开(公告)号：US20080267906A1
公开(公告)日：2008-10-30
申请号：US11792581
申请日：2005-12-09
申请人： Laval Chan Chun Kong , Christophe Moinet , Marc Courchesne , Louis Vaillancourt , Charles Blais , Monica Bubenik
发明人： Laval Chan Chun Kong , Christophe Moinet , Marc Courchesne , Louis Vaillancourt , Charles Blais , Monica Bubenik
IPC分类号： A61K38/20 , C07D487/22 , A61P31/18 , A61P29/00 , A61K31/439
CPC分类号： C07D451/02
摘要： Compounds according to formula (I): wherein A, R1, R2 and R3 are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.
摘要翻译： 根据式（I）的化合物：其中A，R 1，R 2和R 3 3定义如本文所定义，并且药学上可接受的 其盐，水合物和溶剂合物可用于调节CCR5趋化因子受体活性。
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10.发明授权Benzimidazole analogues for the treatment or prevention of flavivirus infections 失效苯并咪唑类似物用于治疗或预防黄病毒感染公开(公告)号：US08354419B2
公开(公告)日：2013-01-15
申请号：US12838350
申请日：2010-07-16
申请人： James A. Henderson , John Maxwell , Louis Vaillancourt , Mark Morris , Ronald Grey, Jr. , Simon Giroux , Laval Chan Chun Kong , Sanjoy Kumar Das , Bingcan Liu , Carl Poisson , Caroline Cadilhac , Monica Bubenik , T. Jagadeeswar Reddy , Guy Falardeau , Constantin Yannopoulos , Jian Wang , Oswy Z. Pereira , Youssef L. Bennani , Albert C. Pierce , Govinda Rao Bhisetti , Kevin M. Cottrell , Valerie Marone
发明人： James A. Henderson , John Maxwell , Louis Vaillancourt , Mark Morris , Ronald Grey, Jr. , Simon Giroux , Laval Chan Chun Kong , Sanjoy Kumar Das , Bingcan Liu , Carl Poisson , Caroline Cadilhac , Monica Bubenik , T. Jagadeeswar Reddy , Guy Falardeau , Constantin Yannopoulos , Jian Wang , Oswy Z. Pereira , Youssef L. Bennani , Albert C. Pierce , Govinda Rao Bhisetti , Kevin M. Cottrell , Valerie Marone
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/4184 , C07D403/14 , C07D401/14
CPC分类号： C07K5/06052 , C07D401/14 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D495/04
摘要： Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B′, X, Y, R1, R1′, R2, R2′, R3, R3′, R5, R5′, R6, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.
摘要翻译： 由式I表示的化合物或其药学上可接受的盐和溶剂化物，其中A，B，B'，X，Y，R1，R1'，R2，R2'，R3，R3'，R5，R5'，R6， n或p如本文所定义，可用于治疗黄病毒科病毒感染。
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