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公开(公告)号：US10653715B2
公开(公告)日：2020-05-19
申请号：US15787398
申请日：2017-10-18
IPC分类号： A61K31/733 , A61K33/06 , A23L33/105 , A61K31/194 , A61K31/198 , A61K31/216 , A61K33/14 , A61K45/06
摘要： The present invention relates to methods for attenuating aging, of health maintenance, and/or treating, or delaying the onset of, an age-related condition or disorder, in a subject comprising administering to the subject an effective amount of (a) one or more compounds that sustain pharmacological activation of xenobiotic metabolism or induce fermentation by gut bacteria to produce substances that activate xenobiotic metabolism enzymes and/or stimulate xenobiotic excretion and (b) one or more chelators. A further aspect of the invention is a composition comprising (a) and (b).
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公开(公告)号：US20240024353A1
公开(公告)日：2024-01-25
申请号：US18476119
申请日：2023-09-27
IPC分类号： A61K31/733 , A61K33/06 , A23L33/105 , A61K31/194 , A61K31/198 , A61K31/216 , A61K33/14 , A61K45/06
CPC分类号： A61K31/733 , A61K33/06 , A23L33/105 , A61K31/194 , A61K31/198 , A61K31/216 , A61K33/14 , A61K45/06 , A23V2002/00 , A23V2250/032 , A23V2250/161 , A23V2250/21 , A23V2250/5062 , A61K2300/00
摘要： The present invention relates to methods for attenuating aging, of health maintenance, and/or treating, or delaying the onset of, an age-related condition or disorder, in a subject comprising administering to the subject an effective amount of (a) one or more compounds that sustain pharmacological activation of xenobiotic metabolism or induce fermentation by gut bacteria to produce substances that activate xenobiotic metabolism enzymes and/or stimulate xenobiotic excretion and (b) one or more chelators. A further aspect of the invention is a composition comprising (a) and (b).
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公开(公告)号：US20210283173A1
公开(公告)日：2021-09-16
申请号：US17328624
申请日：2021-05-24
IPC分类号： A61K31/733 , A61K33/06 , A23L33/105 , A61K31/194 , A61K31/198 , A61K31/216 , A61K33/14 , A61K45/06
摘要： The present invention relates to methods for attenuating aging, of health maintenance, and/or treating, or delaying the onset of, an age-related condition or disorder, in a subject comprising administering to the subject an effective amount of (a) one or more compounds that sustain pharmacological activation of xenobiotic metabolism or induce fermentation by gut bacteria to produce substances that activate xenobiotic metabolism enzymes and/or stimulate xenobiotic excretion and (b) one or more chelators. A further aspect of the invention is a composition comprising (a) and (b).
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4.发明申请公开(公告)号：US20180256617A1
公开(公告)日：2018-09-13
申请号：US15784869
申请日：2017-10-16
IPC分类号： A61K31/704 , A61K31/733 , A61K31/198 , A61K45/06 , A61P35/00 , A61P25/28 , A61P3/04 , A61P3/10
CPC分类号： A61K31/704 , A61K31/198 , A61K31/733 , A61K45/06 , A61K2300/00 , A61P3/04 , A61P3/10 , A61P25/28 , A61P35/00 , G01N2500/00
摘要： The present disclosure relates to methods of extending the lifespan of a subject or treating, suppressing, inhibiting or delaying the onset of an age-related condition or disorder, such as cancer, in a subject. The methods comprise administering to the subject an effective amount of (i) a compound that sustains pharmacological activation of xenobiotic metabolism, (ii) a cardiac glycoside, (iii) a chelator, (iv) inulin, (v) D-valine, or any combination thereof. In a further aspect, the present disclosure relates to a method of identifying clinical candidates by performing a high throughput screening in mammals of test compounds which have great structural and/or functional diversity.
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公开(公告)号：US20200254006A1
公开(公告)日：2020-08-13
申请号：US16859027
申请日：2020-04-27
IPC分类号： A61K31/733 , A61K33/06 , A23L33/105 , A61K31/194 , A61K31/198 , A61K31/216 , A61K33/14 , A61K45/06
摘要： The present invention relates to methods for attenuating aging, of health maintenance, and/or treating, or delaying the onset of, an age-related condition or disorder, in a subject comprising administering to the subject an effective amount of (a) one or more compounds that sustain pharmacological activation of xenobiotic metabolism or induce fermentation by gut bacteria to produce substances that activate xenobiotic metabolism enzymes and/or stimulate xenobiotic excretion and (b) one or more chelators. A further aspect of the invention is a composition comprising (a) and (b).
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