公开(公告)号：US20240158381A1

公开(公告)日：2024-05-16

申请号：US18543599

申请日：2023-12-18

Applicant: Libra Therapeutics, Inc.

Inventor： James Guy BREITENBUCHER ,  Maria Pia CATALANI ,  Ali Munaim YOUSIF

IPC: C07D413/04 ,  C07D263/48 ,  C07D413/12 ,  C07D413/14 ,  C07D491/048 ,  C07D491/056 ,  C07D491/08 ,  C07D491/107 ,  C07D495/10 ,  C07D498/04

CPC classification number: C07D413/04 ,  C07D263/48 ,  C07D413/12 ,  C07D413/14 ,  C07D491/048 ,  C07D491/056 ,  C07D491/08 ,  C07D491/107 ,  C07D495/10 ,  C07D498/04

Abstract: Described herein are oxazole TRPML1 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of TRPML1-mediated disorders or diseases.

公开(公告)号：US12098145B2

公开(公告)日：2024-09-24

申请号：US18543599

申请日：2023-12-18

Applicant: Libra Therapeutics, Inc.

Inventor： James Guy Breitenbucher ,  Maria Pia Catalani ,  Ali Munaim Yousif

IPC: C07D263/48 ,  A61K31/422 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D491/048 ,  C07D491/056 ,  C07D491/08 ,  C07D491/107 ,  C07D495/10 ,  C07D498/04

CPC classification number: C07D413/04 ,  C07D263/48 ,  C07D413/12 ,  C07D413/14 ,  C07D491/048 ,  C07D491/056 ,  C07D491/08 ,  C07D491/107 ,  C07D495/10 ,  C07D498/04

Abstract: Described herein are oxazole TRPML1 agonists and pharmaceutical compositions comprising said agonists. The subject compounds and compositions are useful for the treatment of TRPML1-mediated disorders or diseases.

公开(公告)号：US20240254083A1

公开(公告)日：2024-08-01

申请号：US18559288

申请日：2022-05-11

Applicant: Libra Therapeutics, Inc.

Inventor： James Guy BREITENBUCHER

IPC: C07D211/46 ,  A61K31/395 ,  A61K31/45 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/5375 ,  C07D241/28 ,  C07D265/30 ,  C07D401/12

CPC classification number: C07D211/46 ,  A61K31/45 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/5375 ,  A61K31/5545 ,  C07D241/28 ,  C07D265/30 ,  C07D401/12

Abstract: Described herein are TRPML1 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of TRPML1-mediated disorders or diseases.

公开(公告)号：US20230010299A1

公开(公告)日：2023-01-12

申请号：US17776050

申请日：2020-11-12

Applicant: LIBRA THERAPEUTICS, INC.

Inventor： Paolo PEVARELLO ,  Valentina CUSANO ,  Mariangela SODANO ,  Domenica TORINO ,  Rocco VITALONE ,  Chiara LIBERATI ,  Francesco PISCITELLI

IPC: C07D409/12 ,  C07D295/135 ,  C07C311/21 ,  C07D471/08 ,  C07D295/205 ,  C07D209/08 ,  C07D217/04 ,  C07D401/12 ,  C07D409/14 ,  C07D211/14 ,  C07D211/62 ,  C07D223/08 ,  C07D267/10 ,  C07D307/79 ,  C07D215/36 ,  C07D417/14 ,  C07D265/30

Abstract: Disclosed is a compound of formula (I) or a stereoisomer thereof, or a salt of any of the foregoing and to processes for its preparation. The compounds of formula (I) are useful in the treatment TRPML1-mediated disorders or diseases.