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10 条记录 (耗时 0.02 秒)

    Preparation of targeted liposome systems of a defined size distribution
    1.
    发明授权
    Preparation of targeted liposome systems of a defined size distribution 失效
    制备具有规定尺寸分布的靶向脂质体系统

    公开(公告)号：US5059421A

    公开(公告)日：1991-10-22

    申请号：US370650

    申请日：1989-06-23

    申请人： Helen C. Loughrey ,  Pieter R. Cullis ,  Marcel B. Bally ,  Lewis S. L. Choi ,  Kim F. Wong

    发明人： Helen C. Loughrey ,  Pieter R. Cullis ,  Marcel B. Bally ,  Lewis S. L. Choi ,  Kim F. Wong

    IPC分类号： A61K9/127 ,  A61K47/48

    CPC分类号： A61K9/1271 ,  A61K47/48238 ,  A61K47/48815 ,  A61K9/1277 ,  A61K9/1278

    摘要： The present invention relates to a general method for producing sized protein-liposome conjugates exhibiting enhanced blood circulation times. The present invention also relates to the sized protein-liposome conjugate compositions produced by the method of the present invention. The protein-liposome conjugates of the present invention preferably range in size from about 75 nm to about 200 nm.The liposomes of the invention may have a transmembrane potential across their membranes, and may be dehydrated. In addition, the composition may contain ionizable bioactive agents such as antineplastic agents, and may be used in diagnostic assays.

    摘要翻译： 本发明涉及一种生产显示出增强的血液循环时间的大小的蛋白质 - 脂质体缀合物的一般方法。 本发明还涉及通过本发明的方法制备的大小的蛋白质 - 脂质体缀合物组合物。 本发明的蛋白质 - 脂质体缀合物的大小范围优选为约75nm至约200nm。 本发明的脂质体可跨过其膜具有跨膜电位，并且可以脱水。 此外，组合物可以含有可离子化的生物活性剂，例如抗变性剂，并且可以用于诊断测定。

    Process of synthesis of vinblastine and vincristine
    2.
    发明授权
    Process of synthesis of vinblastine and vincristine 失效
    长春花碱和长春新碱的合成工艺

    公开(公告)号：US5047528A

    公开(公告)日：1991-09-10

    申请号：US228821

    申请日：1988-08-02

    申请人： James P. Kutney ,  Lewis S. L. Choi ,  Jun Nakano ,  Hiroki Tsukamoto ,  Camille A. Boulet ,  Michael McHugh

    发明人： James P. Kutney ,  Lewis S. L. Choi ,  Jun Nakano ,  Hiroki Tsukamoto ,  Camille A. Boulet ,  Michael McHugh

    IPC分类号： C07D519/04

    CPC分类号： C07D519/04

    摘要： The present invention relates to the synthesis of dimer alkaloid compounds, particularly those of the Catharantus (Vinca) family, from an indole unit, such as cantharanthine, and a dihydroindole unit, such as vindoline. A multi-step process is disclosed including the steps of (1) of 1,4-reduction of a first dimeric iminium intermediate to an enamine compound by reaction with a 1,4-dihydropyridine compound; (2) oxidative transformation of the resulting enamine to a second iminium intermediate under controlled aeration; (3) reduction of the second iminium intermediate to form the target dimer alkaloid compounds. The entire process can be conducted in a one-pot operation to obtain the target compounds without isolation of the intermediates.

    摘要翻译： 本发明涉及二烯生物碱化合物，特别是Catharantus（长春花）家族的二聚生物碱化合物，其可以是吲哚单元，例如cantharanthine，以及二氢吲哚单元，例如乙二氢吲哚。 公开了一种多步骤方法，其包括以下步骤：（1）通过与1,4-二氢吡啶化合物反应1,4-还原第一二聚亚胺中间体至烯胺化合物; （2）在受控通气下将所得烯胺氧化转化为第二亚胺中间体; （3）还原第二亚胺中间体以形成目标二聚体生物碱化合物。 整个过程可以在一锅操作中进行，以获得目标化合物而不分离中间体。

    Process of synthesis of 3′,4′-anhydrovinblastine, vinblastine and vincristine
    9.
    再颁专利
    Process of synthesis of 3′,4′-anhydrovinblastine, vinblastine and vincristine 有权
    合成3'，4'-脱氢长春花碱，长春花碱和长春新碱的方法

    公开(公告)号：USRE37449E1

    公开(公告)日：2001-11-13

    申请号：US09437626

    申请日：1999-11-10

    申请人： James P. Kutney ,  Lewis S. L. Choi ,  Jun Nakano ,  Hiroki Tsukamoto ,  Camille A. Boulet ,  Michael McHugh

    发明人： James P. Kutney ,  Lewis S. L. Choi ,  Jun Nakano ,  Hiroki Tsukamoto ,  Camille A. Boulet ,  Michael McHugh

    IPC分类号： C07D51904

    CPC分类号： C07D519/04

    摘要： The present invention relates to the synthesis of dimer alkaloid compounds, particularly those of the Catharantus (Vinca) family, from an indole unit, such as cantharanthine, and a dihydroindole unit, such as vindoline. A multi-step process is disclosed including the steps of (1) of 1,4-reduction of a first dimeric iminium intermediate to an enamine compound by reaction with a 1,4-dihydropyridine compound; (2) oxidative transformation of the resulting enamine to a second iminium intermediate under controlled aeration; (3) reduction of the second iminium intermediate to form the target dimer alkaloid compounds. The entire process can be conducted in a one-pot operation to obtain the target compounds without isolation of the intermediates.

    摘要翻译： 本发明涉及二烯生物碱化合物，特别是Catharantus（长春花）家族的二聚生物碱化合物，其可以是吲哚单元，例如cantharanthine，以及二氢吲哚单元，例如乙二氢吲哚。 公开了一种多步骤方法，其包括以下步骤：（1）通过与1,4-二氢吡啶化合物反应1,4-还原第一二聚亚胺中间体至烯胺化合物; （2）在受控通气下将所得烯胺氧化转化为第二亚胺中间体; （3）还原第二亚胺中间体以形成目标二聚体生物碱化合物。 整个过程可以在一锅操作中进行，以获得目标化合物而不分离中间体。