Method for predicting liver fibrosis and related pathologies
    2.
    发明申请
    Method for predicting liver fibrosis and related pathologies 有权
    预防肝纤维化及相关病理的方法

    公开(公告)号:US20070225919A1

    公开(公告)日:2007-09-27

    申请号:US11388766

    申请日:2006-03-24

    IPC分类号: G06F19/00

    摘要: Provided herein are methods of detecting and staging liver fibrosis in an individual with liver disease. Also provided are methods of detecting necroinflammatory activity. Invention methods utilize four serum markers, age, and gender to determine an end value. The end value is compared to a cut-off value, in order to identify significant fibrosis (METAVIR stages F2 to F4), or an absence of advanced fibrosis (stages F3 and F4) or cirrhosis (stage F4). In particular aspects, progression or treatment of liver fibrosis can be monitored by invention methods. The end value is also used to distinguish between no to mild necroinflammatory activity (METAVIR grade A0 to A1) and moderate to severe necroinflammatory activity (grade A2 to A3).

    摘要翻译: 本文提供了检测和分期肝脏疾病个体肝纤维化的方法。 还提供了检测坏死性炎症活性的方法。 本发明方法利用四种血清标志物,年龄和性别来确定终点值。 将结束值与临界值进行比较,以鉴定明显的纤维化(METAVIR阶段F2至F4),或不存在晚期纤维化(F3和F4期)或肝硬化(F4期)。 在特定方面,肝纤维化的进展或治疗可以通过发明方法来监测。 最终值也用于区分无轻度坏死性炎症活动(METAVIR级别A0至A1)和中度至重度坏死性炎症活动(A2至A3级)。

    Method and system for predicting liver fibrosis and related pathologies
    4.
    发明授权
    Method and system for predicting liver fibrosis and related pathologies 有权
    预防肝纤维化及相关病理的方法和系统

    公开(公告)号:US08676511B2

    公开(公告)日:2014-03-18

    申请号:US11388766

    申请日:2006-03-24

    IPC分类号: G01N33/48

    摘要: Provided herein are methods of detecting and staging liver fibrosis in an individual with liver disease. Also provided are methods of detecting necroinflammatory activity. Invention methods utilize four serum markers, age, and gender to determine an end value. The end value is compared to a cut-off value, in order to identify significant fibrosis (METAVIR stages F2 to F4), or an absence of advanced fibrosis (stages F3 and F4) or cirrhosis (stage F4). In particular aspects, progression or treatment of liver fibrosis can be monitored by invention methods. The end value is also used to distinguish between no to mild necroinflammatory activity (METAVIR grade A0 to A1) and moderate to severe necroinflammatory activity (grade A2 to A3).

    摘要翻译: 本文提供了检测和分期肝脏疾病个体肝纤维化的方法。 还提供了检测坏死性炎症活性的方法。 本发明方法利用四种血清标志物,年龄和性别来确定终点值。 将结束值与临界值进行比较,以鉴定明显的纤维化(METAVIR阶段F2至F4),或不存在晚期纤维化(F3和F4期)或肝硬化(F4期)。 在特定方面,肝纤维化的进展或治疗可以通过发明方法来监测。 最终值也用于区分无轻度坏死性炎症活动(METAVIR级别A0至A1)和中度至重度坏死性炎症活动(A2至A3级)。

    Fuel dispensing nozzle
    7.
    发明授权
    Fuel dispensing nozzle 失效
    燃油分配喷嘴

    公开(公告)号:US4153085A

    公开(公告)日:1979-05-08

    申请号:US906962

    申请日:1978-05-18

    申请人: Leon Adams

    发明人: Leon Adams

    IPC分类号: B67D7/42 B65B3/04 B67D5/37

    CPC分类号: B67D7/42

    摘要: A dispensing nozzle for delivering fuel to selective fuel tanks has a control rod which must be displaced longitudinally by a restrictor plate in the fill tube of the fuel tank before the manual lever of the dispensing nozzle is effective to open the flow controlling valve of the dispensing nozzle. Thus, the introduction of one grade of fuel into a tank not having a restrictor plate and requiring a different grade of fuel is prevented.

    摘要翻译: 用于将燃料输送到选择性燃料箱的分配喷嘴具有控制杆,该控制杆在分配喷嘴的手动杆有效打开分配器的流量控制阀之前必须由燃料箱的填充管中的限制板纵向移动 喷嘴。 因此,防止将一级燃料引入不具有限流板并且需要不同等级的燃料的罐中。