公开(公告)号：US20090279045A1

公开(公告)日：2009-11-12

申请号：US12292049

申请日：2008-11-10

申请人： Bum Soo Kim ,  Byoung Chul Choi ,  Byoung-Mok Ha ,  Chang Bo Shim ,  Chang-soo Na ,  Cheol Joo Moon ,  Chong Chan Eun ,  Gu-Yun Bok ,  Hae Joon Son ,  Heung-Sun Kim ,  Hong Seok Lee ,  Hyung Jin Park ,  Hyun-Ho Song ,  In Kyu Lee ,  Jae Chuon Ryu ,  Jae Ho Shin ,  Jae Min Jong ,  Je Hyun Kim ,  Jeong Ho Lee ,  Jeong-Joon Lee ,  Jong Won Kim ,  Jun Beom Cho ,  Jun Young Yu ,  Jung Seung Kim ,  Jung-Deog Yoo ,  Jung-Sik Kim ,  Se Joon Baek ,  Seung-Bum Lee ,  Seung-Won Moon ,  Sung-mo Koo ,  Tae Man Kim ,  Young Phil Bang ,  Myoung Su Yang ,  Jae Kyun Lee ,  Hyun-Seok Jang ,  Jung Il Lee

发明人： Bum Soo Kim ,  Byoung Chul Choi ,  Byoung-Mok Ha ,  Chang Bo Shim ,  Chang-soo Na ,  Cheol Joo Moon ,  Chong Chan Eun ,  Gu-Yun Bok ,  Hae Joon Son ,  Heung-Sun Kim ,  Hong Seok Lee ,  Hyung Jin Park ,  Hyun-Ho Song ,  In Kyu Lee ,  Jae Chuon Ryu ,  Jae Ho Shin ,  Jae Min Jong ,  Je Hyun Kim ,  Jeong Ho Lee ,  Jeong-Joon Lee ,  Jong Won Kim ,  Jun Beom Cho ,  Jun Young Yu ,  Jung Seung Kim ,  Jung-Deog Yoo ,  Jung-Sik Kim ,  Se Joon Baek ,  Seung-Bum Lee ,  Seung-Won Moon ,  Sung-mo Koo ,  Tae Man Kim ,  Young Phil Bang ,  Myoung Su Yang ,  Jae Kyun Lee ,  Hyun-Seok Jang ,  Jung Il Lee

IPC分类号： G02F1/1341

CPC分类号： G02F1/1341 ,  G02F1/1303

摘要： An LCD device and a method for manufacturing the same is disclosed, in which it is possible to correct a problem of insufficient or excessive supply of liquid crystal in an LCD device by controlling an amount of liquid crystal. The method includes preparing a liquid crystal cell comprised of a first substrate, a second substrate, a liquid crystal layer between the first and second substrates, and a first sealant formed in the periphery of the liquid crystal layer between the first and second substrates; measuring an amount of liquid crystal provided to the inside of liquid crystal cell; forming an inlet for liquid crystal in the first sealant; and regulating the amount of liquid crystal by supplying or discharging the liquid crystal through the inlet; and sealing the inlet.

摘要翻译： 公开了一种LCD装置及其制造方法，其中可以通过控制液晶量来纠正LCD装置中的液晶供应不足或过多的问题。 该方法包括制备由第一基板，第二基板，第一和第二基板之间的液晶层构成的液晶单元，以及形成在第一和第二基板之间的液晶层周边的第一密封剂; 测量提供给液晶单元内部的液晶量; 在第一密封剂中形成液晶的入口; 并通过从入口供给或排出液晶来调节液晶量; 并密封入口。

公开(公告)号：US07450213B2

公开(公告)日：2008-11-11

申请号：US11476919

申请日：2006-06-29

申请人： Bum Soo Kim ,  Byoung Chul Choi ,  Byoung-Mok Ha ,  Chang Bo Shim ,  Chang-Soo Na ,  Cheol Joo Moon ,  Chong Chan Eun ,  Gu-Yun Bok ,  Hae Joon Son ,  Heung-Sun Kim ,  Hong Seok Lee ,  Hyung Jin Park ,  Hyun-Ho Song ,  In Kyu Lee ,  Jae Choon Ryu ,  Jae Ho Shin ,  Jae Min Jong ,  Je Hyun Kim ,  Jeong-Ho Lee ,  Jeong-Joon Lee ,  Jong Won Kim ,  Jun Beom Cho ,  Jun Young Yu ,  Jung Seung Kim ,  Jung-Deog Yoo ,  Jung-Sik Kim ,  Se Joon Baek ,  Seung-Bum Lee ,  Seung-Won Moon ,  Sung-Mo Koo ,  Tae Man Kim ,  Young Phil Bang ,  Myoung Su Yang ,  Jae Kyun Lee ,  Ilyun-Seok Jang ,  Jung Il Lee

发明人： Bum Soo Kim ,  Byoung Chul Choi ,  Byoung-Mok Ha ,  Chang Bo Shim ,  Chang-Soo Na ,  Cheol Joo Moon ,  Chong Chan Eun ,  Gu-Yun Bok ,  Hae Joon Son ,  Heung-Sun Kim ,  Hong Seok Lee ,  Hyung Jin Park ,  Hyun-Ho Song ,  In Kyu Lee ,  Jae Choon Ryu ,  Jae Ho Shin ,  Jae Min Jong ,  Je Hyun Kim ,  Jeong-Ho Lee ,  Jeong-Joon Lee ,  Jong Won Kim ,  Jun Beom Cho ,  Jun Young Yu ,  Jung Seung Kim ,  Jung-Deog Yoo ,  Jung-Sik Kim ,  Se Joon Baek ,  Seung-Bum Lee ,  Seung-Won Moon ,  Sung-Mo Koo ,  Tae Man Kim ,  Young Phil Bang ,  Myoung Su Yang ,  Jae Kyun Lee ,  Ilyun-Seok Jang ,  Jung Il Lee

IPC分类号： G02F1/13 ,  G02F1/1341 ,  G02F1/1339

CPC分类号： G02F1/1341 ,  G02F1/1303

摘要： An LCD device and a method for manufacturing the same is disclosed, in which it is possible to correct a problem of insufficient or excessive supply of liquid crystal in an LCD device by controlling an amount of liquid crystal. The method includes preparing a liquid crystal cell comprised of a first substrate, a second substrate, a liquid crystal layer between the first and second substrates, and a first sealant formed in the periphery of the liquid crystal layer between the first and second substrates; measuring an amount of liquid crystal provided to the inside of liquid crystal cell; forming an inlet for liquid crystal in the first sealant; and regulating the amount of liquid crystal by supplying or discharging the liquid crystal through the inlet; and sealing the inlet.

摘要翻译： 公开了一种LCD装置及其制造方法，其中可以通过控制液晶量来纠正LCD装置中的液晶供应不足或过多的问题。 该方法包括制备由第一基板，第二基板，第一和第二基板之间的液晶层构成的液晶单元，以及形成在第一和第二基板之间的液晶层周边的第一密封剂; 测量提供给液晶单元内部的液晶量; 在第一密封剂中形成液晶的入口; 并通过从入口供给或排出液晶来调节液晶量; 并密封入口。

公开(公告)号：US20080002137A1

公开(公告)日：2008-01-03

申请号：US11476919

申请日：2006-06-29

申请人： Bum Soo Kim ,  Byoung Chul Choi ,  Byoung-Mok Ha ,  Chang Bo Shim ,  Chang-Soo Na ,  Cheol Joo Moon ,  Chong Chan Eun ,  Gu-Yun Bok ,  Hae Joon Son ,  Heung-Sun Kim ,  Hong Seok Lee ,  Hyung Jin Park ,  Hyun-Ho Song ,  In Kye Lee ,  Jae Choon Ryu ,  Jae Ho Shin ,  Jae Min Jong ,  Je Hyun Kim ,  Jeong-Ho Lee ,  Jeong-Joon Lee ,  Jong Won Kim ,  Jun Beom Cho ,  Jun Young Yu ,  Jung Seung Kim ,  Jung-Deog Yoo ,  Jung-Sik Kim ,  Se Joon Baek ,  Seung-Bum Lee ,  Seung-Won Moon ,  Sung-Mo Koo ,  Tae Man Kim ,  Young Phil Bang ,  Myoung Su Yang ,  Jae Kyun Lee ,  Ilyun-Seok Jang ,  Jung Il Lee

发明人： Bum Soo Kim ,  Byoung Chul Choi ,  Byoung-Mok Ha ,  Chang Bo Shim ,  Chang-Soo Na ,  Cheol Joo Moon ,  Chong Chan Eun ,  Gu-Yun Bok ,  Hae Joon Son ,  Heung-Sun Kim ,  Hong Seok Lee ,  Hyung Jin Park ,  Hyun-Ho Song ,  In Kye Lee ,  Jae Choon Ryu ,  Jae Ho Shin ,  Jae Min Jong ,  Je Hyun Kim ,  Jeong-Ho Lee ,  Jeong-Joon Lee ,  Jong Won Kim ,  Jun Beom Cho ,  Jun Young Yu ,  Jung Seung Kim ,  Jung-Deog Yoo ,  Jung-Sik Kim ,  Se Joon Baek ,  Seung-Bum Lee ,  Seung-Won Moon ,  Sung-Mo Koo ,  Tae Man Kim ,  Young Phil Bang ,  Myoung Su Yang ,  Jae Kyun Lee ,  Ilyun-Seok Jang ,  Jung Il Lee

IPC分类号： G02F1/13

CPC分类号： G02F1/1341 ,  G02F1/1303

摘要： An LCD device and a method for manufacturing the same is disclosed, in which it is possible to correct a problem of insufficient or excessive supply of liquid crystal in an LCD device by controlling an amount of liquid crystal. The method includes preparing a liquid crystal cell comprised of a first substrate, a second substrate, a liquid crystal layer between the first and second substrates, and a first sealant formed in the periphery of the liquid crystal layer between the first and second substrates; measuring an amount of liquid crystal provided to the inside of liquid crystal cell; forming an inlet for liquid crystal in the first sealant; and regulating the amount of liquid crystal by supplying or discharging the liquid crystal through the inlet; and sealing the inlet.

公开(公告)号：US08031321B2

公开(公告)日：2011-10-04

申请号：US12292049

申请日：2008-11-10

申请人： Bum Soo Kim ,  Byoung Chul Choi ,  Byoung-Mok Ha ,  Chang Bo Shim ,  Chang-Soo Na ,  Cheol Joo Moon ,  Chong Chan Eun ,  Gu-Yun Bok ,  Hae Joon Son ,  Heung-Sun Kim ,  Hong Seok Lee ,  Hyung Jin Park ,  Hyun-Ho Song ,  In Kyu Lee ,  Jae Chuon Ryu ,  Jae Ho Shin ,  Jae Min Jong ,  Je Hyun Kim ,  Jeong-Ho Lee ,  Jeong-Joon Lee ,  Jong Won Kim ,  Jun Beom Cho ,  Jun Young Yu ,  Jung Seung Kim ,  Jung-Deog Yoo ,  Jung-Sik Kim ,  Se Joon Baek ,  Seung-Bum Lee ,  Seung-Won Moon ,  Sung-Mo Koo ,  Tae Man Kim ,  Young Phil Bang ,  Myoung Su Yang ,  Jae Kyun Lee ,  Hyun-Seok Jang ,  Jung Il Lee

发明人： Bum Soo Kim ,  Byoung Chul Choi ,  Byoung-Mok Ha ,  Chang Bo Shim ,  Chang-Soo Na ,  Cheol Joo Moon ,  Chong Chan Eun ,  Gu-Yun Bok ,  Hae Joon Son ,  Heung-Sun Kim ,  Hong Seok Lee ,  Hyung Jin Park ,  Hyun-Ho Song ,  In Kyu Lee ,  Jae Chuon Ryu ,  Jae Ho Shin ,  Jae Min Jong ,  Je Hyun Kim ,  Jeong-Ho Lee ,  Jeong-Joon Lee ,  Jong Won Kim ,  Jun Beom Cho ,  Jun Young Yu ,  Jung Seung Kim ,  Jung-Deog Yoo ,  Jung-Sik Kim ,  Se Joon Baek ,  Seung-Bum Lee ,  Seung-Won Moon ,  Sung-Mo Koo ,  Tae Man Kim ,  Young Phil Bang ,  Myoung Su Yang ,  Jae Kyun Lee ,  Hyun-Seok Jang ,  Jung Il Lee

IPC分类号： G02F1/13 ,  G02F1/1341 ,  G02F1/1339

CPC分类号： G02F1/1341 ,  G02F1/1303

摘要： An LCD device and a method for manufacturing the same is disclosed, in which it is possible to correct a problem of insufficient or excessive supply of liquid crystal in an LCD device by controlling an amount of liquid crystal. The method includes preparing a liquid crystal cell comprised of a first substrate, a second substrate, a liquid crystal layer between the first and second substrates, and a first sealant formed in the periphery of the liquid crystal layer between the first and second substrates; measuring an amount of liquid crystal provided to the inside of liquid crystal cell; forming an inlet for liquid crystal in the first sealant; and regulating the amount of liquid crystal by supplying or discharging the liquid crystal through the inlet; and sealing the inlet.

摘要翻译： 公开了一种LCD装置及其制造方法，其中可以通过控制液晶量来纠正LCD装置中的液晶供应不足或过多的问题。 该方法包括制备由第一基板，第二基板，第一和第二基板之间的液晶层构成的液晶单元，以及形成在第一和第二基板之间的液晶层周边的第一密封剂; 测量提供给液晶单元内部的液晶量; 在第一密封剂中形成液晶的入口; 并通过从入口供给或排出液晶来调节液晶量; 并密封入口。

公开(公告)号：US20110184888A1

公开(公告)日：2011-07-28

申请号：US12869216

申请日：2010-08-26

申请人： Jeong Man LEE ,  Seyoung MOON ,  Jin Hwan SONG ,  Hyung Jun YOON ,  Kyu Sun LEE ,  In Bum LEE ,  Jae Hun LEE ,  Zooyoung LEE ,  Jin Suk LEE ,  Hyoung Seok LEE ,  Kyung Kook LIM ,  Hyukjae CHOI

发明人： Jeong Man LEE ,  Seyoung MOON ,  Jin Hwan SONG ,  Hyung Jun YOON ,  Kyu Sun LEE ,  In Bum LEE ,  Jae Hun LEE ,  Zooyoung LEE ,  Jin Suk LEE ,  Hyoung Seok LEE ,  Kyung Kook LIM ,  Hyukjae CHOI

IPC分类号： G06F17/00 ,  H02J7/00

CPC分类号： H02J50/80 ,  G06Q50/06 ,  H02J7/025 ,  H02J50/12 ,  H02J50/40

摘要： A system to transmit and receive wireless power, a terminal device, a management server, and a wireless power transmission apparatus may use non-radial wireless energy transmission technology to generate a resonant frequency in resonators and charge a device. The terminal device may receive the wireless power to perform charging by non-contact energy transmission.

摘要翻译： 用于发送和接收无线电力的系统，终端设备，管理服务器和无线电力传输设备可以使用非径向无线能量传输技术来在谐振器中产生谐振频率并对设备充电。 终端设备可以接收无线电力以通过非接触能量传输来执行充电。

公开(公告)号：US20170239259A1

公开(公告)日：2017-08-24

申请号：US14569201

申请日：2014-12-12

申请人： Kyeong LEE ,  Mi Sun WON ,  Hwan Mook KIM ,  Song Kyu PARK ,  Kiho LEE ,  Ki Hoon LEE ,  Chang Woo LEE ,  Jung Joon LEE ,  Kyung Sook CHUNG ,  Bo Kyung KIM ,  Yinglan JIN ,  Seung-hee LEE

发明人： Kyeong LEE ,  Mi Sun WON ,  Hwan Mook KIM ,  Song Kyu PARK ,  Kiho LEE ,  Ki Hoon LEE ,  Chang Woo LEE ,  Jung Joon LEE ,  Kyung Sook CHUNG ,  Bo Kyung KIM ,  Yinglan JIN ,  Seung-hee LEE

IPC分类号： A61K31/5375 ,  A61K31/167 ,  A61K31/196 ,  A61K31/40 ,  A61K31/34 ,  A61K9/08 ,  A61K31/417 ,  A61K9/00 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/24 ,  A61K31/4409

CPC分类号： A61K31/5375 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/167 ,  A61K31/196 ,  A61K31/24 ,  A61K31/34 ,  A61K31/40 ,  A61K31/417 ,  A61K31/4409 ,  C07C233/07 ,  C07C235/28 ,  C07C311/16 ,  C07C311/46 ,  C07C317/40 ,  C07C2603/74 ,  C07D295/088

摘要： The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis.Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.

公开(公告)号：US09096571B2

公开(公告)日：2015-08-04

申请号：US13696400

申请日：2011-05-04

申请人： Je Ho Ryu ,  Shin Ae Kim ,  Keun Ho Ryu ,  Jae Sun Kim ,  Nam Ho Kim ,  Hye Young Han ,  Yong Hyuk Kim ,  Won-No Youn ,  Yoon-Jung Lee ,  Hyun Joo Son ,  Bong-Yong Lee ,  Sung Hoon Park ,  Ju Young Lee ,  Hyun Jung Lee ,  Hoe Chul Jung ,  Young Ah Shin ,  Jung A Lee ,  Bo Ram Lee ,  Joon Ho Sa

发明人： Je Ho Ryu ,  Shin Ae Kim ,  Keun Ho Ryu ,  Jae Sun Kim ,  Nam Ho Kim ,  Hye Young Han ,  Yong Hyuk Kim ,  Won-No Youn ,  Yoon-Jung Lee ,  Hyun Joo Son ,  Bong-Yong Lee ,  Sung Hoon Park ,  Ju Young Lee ,  Hyun Jung Lee ,  Hoe Chul Jung ,  Young Ah Shin ,  Jung A Lee ,  Bo Ram Lee ,  Joon Ho Sa

IPC分类号： A61K31/47 ,  A61K31/55 ,  A61K31/445 ,  A61K31/497 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D213/81 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D239/557

CPC分类号： C07D401/04 ,  C07D213/81 ,  C07D239/557 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14

摘要： Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11β-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11β-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human-derived 11β-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LADA), insulin tolerance syndromes, obesity, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.

摘要翻译： 提供了吡啶酰胺和嘧啶-4-甲酰胺化合物，其制备方法，含有该组合物的药物组合物，以及使用该化合物作为预防，调节和治疗与糖皮质激素调节有关的疾病的药物的用途 该化合物对于11-bgr-HSD1酶的选择性抑制活性。 本发明的吡啶酰胺和嘧啶-4-甲酰胺化合物是人源性11β-HSD1酶的选择性抑制剂，可用于预防，调节和治疗糖皮质激素调节相关疾病的药剂，其中人源性11β- ; -HSD1酶涉及例如代谢综合征，如1型和2型糖尿病，糖尿病后期并发症，潜伏性自身免疫性糖尿病成人（LADA），胰岛素耐受综合征，肥胖，葡萄糖耐量异常（IGT），空腹血糖受损 （IFG），葡萄糖耐量受损，血脂异常，动脉粥样硬化，高血压等。

公开(公告)号：US20130210811A1

公开(公告)日：2013-08-15

申请号：US13696400

申请日：2011-05-04

申请人： Je Ho Ryu ,  Shin Ae Kim ,  Keun Ho Ryu ,  Jae Sun Kim ,  Nam Ho Kim ,  Hye Young Han ,  Yong Hyuk Kim ,  Won-No Youn ,  Yoon-Jung Lee ,  Hyun Joo Son ,  Bong-Yong Lee ,  Sung Hoon Park ,  Ju Young Lee ,  Hyun Jung Lee ,  Hoe Chul Jung ,  Young Ah Shin ,  Jung A Lee ,  Bo Ram Lee ,  Joon Ho Sa

发明人： Je Ho Ryu ,  Shin Ae Kim ,  Keun Ho Ryu ,  Jae Sun Kim ,  Nam Ho Kim ,  Hye Young Han ,  Yong Hyuk Kim ,  Won-No Youn ,  Yoon-Jung Lee ,  Hyun Joo Son ,  Bong-Yong Lee ,  Sung Hoon Park ,  Ju Young Lee ,  Hyun Jung Lee ,  Hoe Chul Jung ,  Young Ah Shin ,  Jung A Lee ,  Bo Ram Lee ,  Joon Ho Sa

IPC分类号： C07D401/04 ,  C07D403/14 ,  C07D403/04 ,  C07D401/14 ,  C07D405/14

CPC分类号： C07D401/04 ,  C07D213/81 ,  C07D239/557 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14

摘要： Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11β-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11β-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human-derived 11β-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LADA), insulin tolerance syndromes, obesity, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.

摘要翻译： 提供了吡啶酰胺和嘧啶-4-甲酰胺化合物，其制备方法，含有该组合物的药物组合物，以及使用该化合物作为预防，调节和治疗与糖皮质激素调节有关的疾病的药物的用途 化合物对11beta-HSD1酶的选择性抑制活性。 本发明的吡啶酰胺和嘧啶-4-甲酰胺化合物是人源性11beta-HSD1酶的选择性抑制剂，可用于预防，调节和治疗与糖皮质激素调节相关的疾病的药剂，其中人源性11β- 涉及HSD1酶，例如代谢综合征，如1型和2型糖尿病，糖尿病后期并发症，潜伏性自身免疫性糖尿病成年（LADA），胰岛素耐受综合征，肥胖症，葡萄糖耐量异常（IGT），空腹血糖受损（IFG ），葡萄糖耐量受损，血脂异常，动脉粥样硬化，高血压等。

公开(公告)号：US09103599B2

公开(公告)日：2015-08-11

申请号：US13598629

申请日：2012-08-30

申请人： Wei-Ching Lee ,  Tzu-I Lee ,  Yu-Jieh Lee ,  Yu-Hsuan Lee ,  Peng-Chieh Lee ,  Po-Chang Lee

发明人： Wei-Ching Lee ,  Tzu-I Lee ,  Yu-Jieh Lee ,  Yu-Hsuan Lee ,  Peng-Chieh Lee ,  Po-Chang Lee

IPC分类号： F28D5/00 ,  F28D15/00 ,  F28F27/00

CPC分类号： F28D15/00 ,  F24F1/02 ,  F24F13/082 ,  F24F13/22 ,  F24F2013/225 ,  F25B49/027 ,  F25B2339/041 ,  F28D1/024 ,  F28D5/00 ,  F28D2021/007 ,  F28F9/22 ,  F28F17/005 ,  F28F27/00 ,  F28F2009/228

摘要： The invention provides a flake and method for reducing waste heat using water produced when an air conditioner operates and thereby heat exchange efficiency can increase. Accordingly, an energy-saving effect can be achieved. The flake is placed at an inner bottom side of the air conditioner and between a condenser fan and a condenser coil. When the condenser fan operates, wind power created by the condenser fan has a portion blowing toward the flake, and then blowing toward underlying water, produced when the air conditioner operates, along the flake such that the water can move to the condenser coil and cool the condenser coil. Thereby, the temperature of discharged waste heat can be reduced. When the condenser coil cools, heat exchange efficiency increases. Accordingly, an indoor cooling effect can be improved and an energy-saving effect can be achieved.

摘要翻译： 本发明提供了一种使用空调操作时产生的水来减少余热并从而提高热交换效率的薄片和方法。 因此，能够实现节能效果。 薄片放置在空调的内底侧，在冷凝器风扇和冷凝器盘管之间。 当冷凝器风扇工作时，由冷凝器风扇产生的风力具有朝向薄片吹出的部分，然后朝着空气调节器操作时产生的下水吹向薄片，使得水可以移动到冷凝器盘管并冷却 冷凝器盘管。 由此，排出的废热的温度可以降低。 当冷凝器盘管冷却时，热交换效率提高。 因此，能够提高室内冷却效果，能够实现节能效果。

公开(公告)号：US08940936B2

公开(公告)日：2015-01-27

申请号：US13880642

申请日：2011-10-17

申请人： Kyeong Lee ,  Mi Sun Won ,  Hwan Mook Kim ,  Song Kyu Park ,  Kiho Lee ,  Ki Hoon Lee ,  Chang Woo Lee ,  Jung Joon Lee ,  Kyung Sook Chung ,  Bo Kyung Kim ,  Yinglan Jin ,  Seung-hee Lee

发明人： Kyeong Lee ,  Mi Sun Won ,  Hwan Mook Kim ,  Song Kyu Park ,  Kiho Lee ,  Ki Hoon Lee ,  Chang Woo Lee ,  Jung Joon Lee ,  Kyung Sook Chung ,  Bo Kyung Kim ,  Yinglan Jin ,  Seung-hee Lee

IPC分类号： C07C233/07 ,  A61K31/167 ,  C07C235/28 ,  C07C311/16 ,  C07D295/088

CPC分类号： A61K31/5375 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/167 ,  A61K31/196 ,  A61K31/24 ,  A61K31/34 ,  A61K31/40 ,  A61K31/417 ,  A61K31/4409 ,  C07C233/07 ,  C07C235/28 ,  C07C311/16 ,  C07C311/46 ,  C07C317/40 ,  C07C2603/74 ,  C07D295/088

摘要： The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.

摘要翻译： 本发明涉及抑制HF-1活性的化合物，其制备方法以及含有该化合物作为活性成分的药物组合物。 本发明的化合物通过非选择性细胞毒性表现出抗癌活性，但通过抑制HIF-1的活性，该转录因子在癌细胞生长和转移中起重要作用。 因此，根据本发明的化合物或其药学上可接受的盐抑制HIF-1活性，因此可以用作结肠癌，肝癌，胃癌和乳腺癌等实体瘤的治疗剂。 此外，根据本发明的化合物或其药学上可接受的盐可以用作用于糖尿病性视网膜病变或关节炎的治疗剂的活性成分，当HIF-1的缺氧诱导的VEGF表达增加时，可能变差。