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公开(公告)号：US11903720B2
公开(公告)日：2024-02-20
申请号：US16741549
申请日：2020-01-13
CPC分类号： A61B5/4088 , A61B3/0025 , A61B3/0091 , A61B3/113 , A61B5/4842 , A61B5/4848
摘要： A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.
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公开(公告)号：US20220168704A1
公开(公告)日：2022-06-02
申请号：US17594074
申请日：2020-03-31
申请人： CSP TECHNOLOGIES, INC. , LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , L'UNIVERSITE DE HAUTE ALSACE
发明人： Zakaria TAHRAOUI , Patrice FORLER , Jean DAOU , Claire MARICHAL , Habiba NOUALI
摘要： This invention relates generally to zeolites and polymer compositions with zeolites having enhanced adsorption capacity for adsorption of water, ammonia and other similar compounds. The invention is directed particularly to aluminosilicate zeolites, and methods for preparing zeolite entrained polymer compositions having enhanced water adsorption properties. This invention relates also to improved packaging materials with enhanced water adsorption properties incorporating the polymer compositions containing zeolites.
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公开(公告)号：US20190375703A1
公开(公告)日：2019-12-12
申请号：US16472716
申请日：2017-06-30
发明人： Alban CHAPPAZ , Francois JEROME , Karine DE OLIVEIRA VIGIER , Eric MULLER , Jonathan LAI , Matthieu CORBET , Didier MORVAN
IPC分类号： C07C67/29 , C07C69/716 , B01J31/22
摘要： A process for synthesizing at least one levulinate ester, said process comprising the reaction of furfuryl alcohol with at least one other alcohol in the presence of water and at least one catalyst, said furfuryl alcohol being present in a quantity of at least 5% by weight, based on the total weight of the alcohols, and said catalyst comprising at least one triflate ligand and at least one metal selected from bismuth, gallium, aluminum, tin and iron.
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公开(公告)号：US20170174669A1
公开(公告)日：2017-06-22
申请号：US15250742
申请日：2016-08-29
IPC分类号： C07D405/12 , C07D495/04 , C07D405/14
CPC分类号： C07D405/12 , A61K31/4523 , A61K31/454 , A61K31/706 , C07D313/00 , C07D405/14 , C07D495/04 , C07H15/26
摘要： The present invention includes novel derivatives, analogs, and intermediates of the natural products radicicol, pochonins, pochoximes, and their syntheses. The present invention also provides a pharmaceutical composition comprising the present compound and the use of the compound as inhibitors of kinases and of the enzyme family known as heat shock protein 90 (HSP90).
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公开(公告)号：US08575300B2
公开(公告)日：2013-11-05
申请号：US13676201
申请日：2012-11-14
发明人： Ming-Hong Hung , Bruno Ameduri , Georgi Kostov
IPC分类号： C08G63/78
CPC分类号： C08F261/06 , C08F214/18
摘要： Disclosed herein is a telechelic diacrylate fluoropolymer and a process for manufacture of the fluoropolymer. The diacrylate copolymer is of formula CH2═CR′COO—(CH2)n—R—(CH2)n—OOCCR′═CH2, wherein R is selected from the group consisting of i) an oligomer comprising copolymerized units of vinylidene fluoride and perfluoro(methyl vinyl ether), ii) an oligomer comprising copolymerized units of vinylidene fluoride and hexafluoropropylene, iii) an oligomer comprising copolymerized units of tetrafluoroethylene and perfluoro(methyl vinyl ether), and iv) an oligomer comprising copolymerized units of tetrafluoroethylene and a hydrocarbon olefin, R′ is H or—CH3, n is 1-4 and wherein said oligomer has a number average molecular weight of 1000 to 25,000 daltons.
摘要翻译： 本文公开了遥爪二丙烯酸酯含氟聚合物和制造含氟聚合物的方法。 二丙烯酸酯共聚物具有式CH2 = CR'COO-（CH2）nR-（CH2）n-OOCCR'= CH2，其中R选自i）包含偏二氟乙烯和全氟（甲基）丙烯的共聚单元的低聚物 乙烯基醚），ii）包含偏二氟乙烯和六氟丙烯的共聚单元的低聚物，iii）包含四氟乙烯和全氟（甲基乙烯基醚）的共聚单元的低聚物，和iv）包含四氟乙烯和烃烯烃的共聚单元的低聚物，R '是H或-CH 3，n为1-4，并且其中所述低聚物的数均分子量为1000至25,000道尔顿。
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公开(公告)号：US20240188879A1
公开(公告)日：2024-06-13
申请号：US18581101
申请日：2024-02-19
CPC分类号： A61B5/4088 , A61B3/0025 , A61B3/0091 , A61B3/113 , A61B5/4842 , A61B5/4848
摘要： A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.
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公开(公告)号：US20220370394A1
公开(公告)日：2022-11-24
申请号：US17774684
申请日：2020-11-06
申请人： GIVAUDAN SA , AVIGNON UNIVERSITE , L'UNIVERSITÉ DE MONTPELLIER , LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , L,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
发明人： Doria BOULGHOBRA , Michael LAGUERRE , Mathieu TENON , Jérémy FAUCONNIER , Simona BIRTIC , Pascale Elizabeth Renée FANÇA-BERTHON , Cyril REBOUL , Olivier CAZORLA
IPC分类号： A61K31/216 , A61K36/31 , A23L33/105 , A61P21/06
摘要： The present invention relates to compounds having a lipid affinity of less than 15% by weight of the compound (such as a log P of −0.75 or less) for use in targeting mitochondria to reduce, inhibit or prevent the formation of mitochondrial reactive oxygen species and for use in treating or preventing a pathological condition associated with increased levels of mitochondrial reactive oxygen species, and for non-therapeutic uses, such as enhancing sports performance and reducing, inhibiting or preventing the formation of mitochondrial reactive oxygen species during exercise, resulting in maintenance of muscle strength and/or a reduction in muscle fatigue, and associated methods. The present invention also relates to extracts and compositions comprising compounds having a lipid affinity of less than 15% (such as a log P of −0.75 or less) for the same uses.
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公开(公告)号：US20200146611A1
公开(公告)日：2020-05-14
申请号：US16741549
申请日：2020-01-13
摘要： A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.
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公开(公告)号：US10537276B2
公开(公告)日：2020-01-21
申请号：US15958403
申请日：2018-04-20
摘要： A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.
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公开(公告)号：US09962119B2
公开(公告)日：2018-05-08
申请号：US14893552
申请日：2014-04-23
CPC分类号： A61B5/4088 , A61B3/0025 , A61B3/0091 , A61B3/113 , A61B5/4842 , A61B5/4848
摘要： A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and infersaccatic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.
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