公开(公告)号：US20220370394A1

公开(公告)日：2022-11-24

申请号：US17774684

申请日：2020-11-06

申请人： GIVAUDAN SA ,  AVIGNON UNIVERSITE ,  L'UNIVERSITÉ DE MONTPELLIER ,  LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  L,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

发明人： Doria BOULGHOBRA ,  Michael LAGUERRE ,  Mathieu TENON ,  Jérémy FAUCONNIER ,  Simona BIRTIC ,  Pascale Elizabeth Renée FANÇA-BERTHON ,  Cyril REBOUL ,  Olivier CAZORLA

IPC分类号： A61K31/216 ,  A61K36/31 ,  A23L33/105 ,  A61P21/06

摘要： The present invention relates to compounds having a lipid affinity of less than 15% by weight of the compound (such as a log P of −0.75 or less) for use in targeting mitochondria to reduce, inhibit or prevent the formation of mitochondrial reactive oxygen species and for use in treating or preventing a pathological condition associated with increased levels of mitochondrial reactive oxygen species, and for non-therapeutic uses, such as enhancing sports performance and reducing, inhibiting or preventing the formation of mitochondrial reactive oxygen species during exercise, resulting in maintenance of muscle strength and/or a reduction in muscle fatigue, and associated methods. The present invention also relates to extracts and compositions comprising compounds having a lipid affinity of less than 15% (such as a log P of −0.75 or less) for the same uses.