公开(公告)号：US12082985B2

公开(公告)日：2024-09-10

申请号：US17048018

申请日：2019-04-16

申请人： Centre National de la Recherche Scientifique ,  UNIVERSITE PARIS XII—VAL DE MARNE ,  L'ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS

发明人： Guillaume Haiat ,  Romain Vayron

IPC分类号： A61C19/04 ,  A61B5/00 ,  A61B8/08 ,  A61C8/00

CPC分类号： A61C19/04 ,  A61B5/4504 ,  A61B5/4542 ,  A61B8/0858 ,  A61B8/0875 ,  A61B8/5223 ,  A61C8/0089

摘要： Device for inspecting the stability of a dental implant (1) in a bone (2), the implant having a free end (1a) and an end (1b) buried in the bone (2). The device comprises an ultrasonic transducer (12) for emitting and collecting an ultrasonic wave reflected from a contact interface (4) between the implant (1) and the bone (2), and providing a measurement signal representing the reflected ultrasonic wave. The device also comprises a processing unit for computing, based on the measurement signal, an indicator (IN) whose value makes it possible to evaluate the integration of the implant (1) into the bone (2). The indicator (IN) corresponds to the average energy of the measurement signal over a time interval (t1-t2) starting at a first time (t1) and ending at a second time (t2). The first time (t1) is between 20 and 80 μs after the start of the emission of the ultrasonic wave.

公开(公告)号：US20210032705A1

公开(公告)日：2021-02-04

申请号：US17011990

申请日：2020-09-03

申请人： INSTITUT PASTEUR ,  ECOLE NATIONALE VETERINAIRE D'ALFORT ,  PATHOQUEST ,  L'ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

发明人： Marc ELOIT ,  Nicolas TORNO ,  Jean DEREGNAUCOURT ,  Marion MOUTON ,  Isabelle HEARD ,  Philippe PEROT

IPC分类号： C12Q1/6886 ,  C12Q1/70 ,  G16H50/30

摘要： The present invention provides compositions, kits, and method for determining the levels of expression of human polyoma or papillomavirus species and RNA transcripts. These levels can be used for the prognosis of risk of developing virally-induced cancers. The ratio (R) between early and late transcripts is indicative of HPV infections associated with higher risk of developing genital neoplasia and cancer.

公开(公告)号：US10808284B2

公开(公告)日：2020-10-20

申请号：US15319893

申请日：2015-07-07

申请人： INSTITUT PASTEUR ,  ECOLE NATIONALE VETERINAIRE D'ALFORT ,  PATHOQUEST ,  L'ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS

发明人： Marc Eloit ,  Nicolas Torno ,  Jean Deregnaucourt ,  Marion Mouton ,  Isabelle Heard ,  Philippe Perot

IPC分类号： C12Q1/6886 ,  C12Q1/70 ,  G16H50/30

摘要： The present invention provides compositions, kits, and method for determining the levels of expression of human polyoma or papillomavirus species and RNA transcripts. These levels can be used for the prognosis of risk of developing virally-induced cancers. The ratio (R) between early and late transcripts is indicative of HPV infections associated with higher risk of developing genital neoplasia and cancer.

公开(公告)号：US11530452B2

公开(公告)日：2022-12-20

申请号：US17011990

申请日：2020-09-03

申请人： INSTITUT PASTEUR ,  ECOLE NATIONALE VETERINAIRE D'ALFORT ,  PATHOQUEST ,  L'ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS

发明人： Marc Eloit ,  Nicolas Torno ,  Jean Deregnaucourt ,  Marion Mouton ,  Isabelle Heard ,  Philippe Perot

IPC分类号： C12Q1/70 ,  C12Q1/6844 ,  C12Q1/6886 ,  G16H50/30

摘要： The present invention provides compositions, kits, and method for determining the levels of expression of human polyoma or papillomavirus species and RNA transcripts. These levels can be used for the prognosis of risk of developing virally-induced cancers. The ratio (R) between early and late transcripts is indicative of HPV infections associated with higher risk of developing genital neoplasia and cancer.

公开(公告)号：US20210106415A1

公开(公告)日：2021-04-15

申请号：US17048018

申请日：2019-04-16

申请人： Centre National de la Recherche Scientifique ,  UNIVERSITE PARIS XII - VAL DE MARNE ,  L'ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

发明人： Guillaume Haiat ,  Romain Vayron

IPC分类号： A61C19/04 ,  A61B8/08 ,  A61B5/00 ,  A61C8/00

摘要： Device for inspecting the stability of a dental implant (1) in a bone (2), the implant having a free end (1a) and an end (1b) buried in the bone (2). The device comprises an ultrasonic transducer (12) for emitting and collecting an ultrasonic wave reflected from a contact interface (4) between the implant (1) and the bone (2), and providing a measurement signal representing the reflected ultrasonic wave. The device also comprises a processing unit for computing, based on the measurement signal, an indicator (IN) whose value makes it possible to evaluate the integration of the implant (1) into the bone (2). The indicator (IN) corresponds to the average energy of the measurement signal over a time interval (t1-t2) starting at a first time (t1) and ending at a second time (t2). The first time (t1) is between 20 and 80 μs after the start of the emission of the ultrasonic wave.

公开(公告)号：US20170107582A1

公开(公告)日：2017-04-20

申请号：US15319893

申请日：2015-07-07

申请人： INSTITUT PASTEUR ,  ECOLE NATIONALE VETERINAIRE D'ALFORT ,  PATHOQUEST ,  L'ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

发明人： Marc ELOIT ,  Nicolas TORNO ,  Jean DEREGNAUCOURT ,  Marion MOUTON ,  Isabelle HEARD ,  Philippe PEROT

IPC分类号： C12Q1/68 ,  G06F19/00 ,  C12Q1/70

CPC分类号： C12Q1/6886 ,  C12Q1/70 ,  C12Q1/708 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  G16H50/30 ,  C12Q2525/15 ,  C12Q2537/165 ,  C12Q2545/114

摘要： The present invention provides compositions, kits, and method for determining the levels of expression of human polyoma or papillomavirus species and RNA transcripts. These levels can be used for the prognosis of risk of developing virally-induced cancers. The ratio (R) between early and late transcripts is indicative of HPV infections associated with higher risk of developing genital neoplasia and cancer.