Method for removing and reducing hepatitis C virus
    1.
    发明授权
    Method for removing and reducing hepatitis C virus 失效
    丙型肝炎病毒除去和减少的方法

    公开(公告)号:US06713252B2

    公开(公告)日:2004-03-30

    申请号:US10180098

    申请日:2002-06-27

    IPC分类号: C12Q170

    CPC分类号: A61M1/3679

    摘要: Described is a method of removing and reducing HCV from the blood of an HCV-infected patient, which comprises carrying out, once a day for at least 5 straight days, a treatment of bringing the blood into contact with an adsorptive carrier having a higher affinity for infected, activated and/or defective leukocytes than for uninfected leukocytes. The treatment according to the present invention makes it possible to markedly reduce the blood HCV level of a patient suffering from Hepatitis C, thereby enabling antiviral therapy, for example, treatment with interferon. This brings a drastic improvement in the cure rate for Hepatitis C.

    摘要翻译: 描述了从HCV感染患者的血液中除去和减少HCV的方法,其包括每天一次持续至少连续5天进行使血液与具有较高亲和力的吸附载体接触的治疗 对于感染的,活化的和/或有缺陷的白细胞比未感染的白细胞。 根据本发明的治疗使得可以显着降低患有丙型肝炎的患者的血液HCV水平,由此进行抗病毒治疗,例如用干扰素治疗。 这大大提高了丙型肝炎的治愈率。

    Fluid-filled cushioning device having sealing arrangement for easy
assembling
    2.
    发明授权
    Fluid-filled cushioning device having sealing arrangement for easy assembling 失效
    具有密封装置的流体填充缓冲装置,便于组装

    公开(公告)号:US5005810A

    公开(公告)日:1991-04-09

    申请号:US215305

    申请日:1988-07-05

    IPC分类号: B60G7/02 F16F13/16 F16F9/14

    摘要: A fluid-filled cushioning device having a cylindrical elastic body mounted on an inner sleeve and having an orifice structure with an orifice formed therethrough is disclosed. A pair of annular elastic members each having a retainer member and an outer sleeve are mounted on the inner sleeve such that the retainer member is press-fitted in the axial end portion of the inner sleeve while the orifice structure is sandwiched between the axial end faces of the outer sleeves, in the axial direction. A bracket is mounted on the outer sleeves of the elastic members and is fixed to a support member, so that the bracket forces the outer sleeves against the orifice structure. The inner sleeve, elastic body and elastic members define two fluid-filled chambers which are separated from each other by the elastic body and which communicate with each other through the orifice. An axial dimension of each elastic member before being mounted on the inner sleeve is determined to permit each elastic member to be axially compressed upon mounting of the elastic members, so that the outer sleeves are urged against the orifice structure with a force sufficient to maintain fluid tightness between the elastic members and the orifice structure, whereby the mounting of the bracket on the outer sleeves of the elastic members may be effected in a condition that the fluid chambers are filled with the fluid.

    摘要翻译: 公开了一种流体填充缓冲装置,其具有安装在内套筒上并具有孔结构的圆柱形弹性体,孔结构具有通过其形成的孔口。 一对环形弹性构件,每个具有保持构件和外套筒,安装在内套筒上,使得保持构件压配合在内套筒的轴向端部中,同时孔结构夹在轴向端面 的外套,沿轴向。 支架安装在弹性构件的外套上,并固定在支撑构件上,使支架迫使外套靠在孔结构上。 内套筒,弹性体和弹性构件限定两个流体填充室,它们通过弹性体彼此分离并且通过孔彼此连通。 确定每个弹性构件在安装到内套筒之前的轴向尺寸,以允许每个弹性构件在安装弹性构件时被轴向压缩,使得外套件以足以维持流体的力被推靠在孔结构上 弹性构件与孔口结构之间的紧密度,从而可以在流体室充满流体的情况下将支架安装在弹性构件的外套上。

    Liquid-sealed body mount
    3.
    发明授权
    Liquid-sealed body mount 失效
    液体密封体安装

    公开(公告)号:US4936556A

    公开(公告)日:1990-06-26

    申请号:US357426

    申请日:1989-05-25

    CPC分类号: F16F13/16

    摘要: A liquid-sealed body mount comprising an inner and an outer cylinders concentrically disposed, a first and a second rubber members provided mutually in axially spaced relation and connecting both cylinders therebetween, an intermediate rubber plate means partitioning axially an enclosure surrounded by both cylinders and both rubber members into a first and a second liquid chambers, an orifice for communication with both chambers apertured in the intermediate means, and a liquid filled in both chambers. The intermediate rubber plate means is configured, when assembled, so as to be preliminarily deformed in the shearing direction, assuming a shade-like form and, when imposed with a prescribed load, so as to retain a neutral state of intersecting orthogonally both cylinders, whereby equalized vibration-preventing characteristics against oscillations on both bound and rebound sides are achieved.

    摘要翻译: 一种液体密封的主体安装件,包括同心地设置的内部和外部气缸,第一和第二橡胶构件,其相互轴向间隔开地设置并连接两个气缸;中间橡胶板装置,轴向地分隔由两个气缸和两个气缸围绕的外壳 橡胶构件成为第一和第二液体室,用于与在中间装置中开孔的两个室连通的孔口以及填充在两个室中的液体。 中间橡胶板装置在组装时被构造成在剪切方向上预先变形,假设为阴影形状,并且当以规定的载荷施加时,保持与正交相交的两个气缸的中立状态, 从而实现了抵抗和回弹侧的振动均衡的防振特性。

    Bush with a spherical sliding surface
    4.
    发明授权
    Bush with a spherical sliding surface 失效
    布置有球面滑动面

    公开(公告)号:US4714368A

    公开(公告)日:1987-12-22

    申请号:US917961

    申请日:1986-10-14

    IPC分类号: F16C11/06

    摘要: A bush with a sliding surface comprising a socket, a ball-integral shaft having shaft portions on both sides of a ball portion, a bearing body location between the socket and the ball-integral shaft, and a cushion having recesses in at least one axial end portions thereof constructed of polyurethane resins or polyester resins. Excellent absorption of manufacturing tolerances of parts of the bush and easy adjustment of rotational torque of the bush in normal operating conditions are obtained through use of the bush of the present invention. Additionally, the bush can show excellent load bearing characteristics even when the bush receives large loads beyond normal operating loads. Further, the durability of the bush is improved.

    摘要翻译: 一种具有滑动表面的衬套,包括一个插座,一个在球形部分的两侧具有轴部分的球形整体轴,在该插座和球形一体轴之间的一个轴承体位置,以及一个在至少一个轴向上具有凹槽的衬垫 其端部由聚氨酯树脂或聚酯树脂构成。 通过使用本发明的衬套,可以很好地吸收衬套部件的制造公差以及在正常工作条件下容易地调整衬套的转矩。 此外,即使当衬套承受超过正常工作负载的大负载时,衬套也可显示出优异的承载特性。 此外,衬套的耐久性提高。

    Production method of pattern for casting
    5.
    发明授权
    Production method of pattern for casting 失效
    铸造图案的生产方法

    公开(公告)号:US6007280A

    公开(公告)日:1999-12-28

    申请号:US19102

    申请日:1998-02-05

    IPC分类号: B22C7/02 G05B19/4099 B23C3/00

    摘要: A method for improving dimensional accuracy of a casting pattern. A division block used to form the casting pattern is fixed on a block fixing surface of an NC machine and then the front surface is processed, leaving a stiffness holding portion at a bottom-most portion of the division block. The division block is then turned over and the rear surface is processed, removing the stiffness holding portion. The stiffness holding portion has sufficient thickness to secure stiffness of portions surrounding a through portion, enabling withstanding of a cutting force applied to the rear surface when the division block is turned over and the rear surface processed. Thus, a deviation in position of the tool during processing of the through hole on the rear surface from that of processing of the through hole on the front surface is suppressed.

    摘要翻译: 一种用于提高铸造图案的尺寸精度的方法。 用于形成铸造图案的分割块固定在NC机器的块固定面上,然后处理前表面,在分割块的最底部留下刚度保持部。 然后将分割块翻转并且后表面被处理,去除刚度保持部分。 刚度保持部分具有足够的厚度以确保围绕通过部分的部分的刚度,使得能够在分割块翻转并且后表面被处理时承受施加到后表面的切割力。 因此,能够抑制在前表面的贯通孔的后表面的通孔的加工过程中工具的位置偏离与前表面的贯通孔的加工位置的偏差。

    Fluid-filled elastic cushioning device having stopper block for closing
orifice upon excessive load application
    6.
    发明授权
    Fluid-filled elastic cushioning device having stopper block for closing orifice upon excessive load application 失效
    流体填充的弹性缓冲装置具有用于在过度加载时关闭孔口的止动块

    公开(公告)号:US4844430A

    公开(公告)日:1989-07-04

    申请号:US240519

    申请日:1988-09-06

    摘要: A fluid-filled elastic cushioning device for elastically connecting a first and a second member, including an inner sleeve attached to the first member, an elastic body fitted on the inner sleeve and having two pockets which are open in opposite axial end faces of the elastic body, two closure members for closing the open ends of the pockets to thereby form two fluid chambers, an orifice member embedded in the elastic body and having an orifice communicating with the fluid chambers, and a mounting plate secured to the orifice member. At least one of opposite ends of the orifice is open at a bottom of the corresponding at least one of the pockets, and at least one stopper rubber block is secured to each of at least one of the closure members which closes the corresponding at least one of the pockets. Each rubber block extends into the corresponding one of the fluid chambers such that a free end of each rubber block is normally spaced apart from the corresponding open end of the orifice. Each rubber block is abuttable at the free end thereof on the corresponding end of the orifice member, to thereby close the orifice at the corresponding open end, when the cushioning device is subjected to an excessive vibrational load.

    摘要翻译: 一种用于弹性连接第一和第二构件的流体填充的弹性缓冲装置,包括附接到第一构件的内套筒,弹性体装配在内套筒上,并且具有两个在弹性件的相对的轴向端面上敞开的口袋 两个闭合构件,用于封闭凹穴的开口端,从而形成两个流体室;嵌入在弹性体中并具有与流体室连通的孔口的孔口构件;以及固定到孔口构件的安装板。 孔口的相对端部中的至少一个在相应的至少一个凹穴的底部是开放的,并且至少一个止动橡胶块固定到至少一个封闭构件中的每一个上,封闭相应的至少一个 的口袋。 每个橡胶块延伸到相应的一个流体室中,使得每个橡胶块的自由端通常与孔口的相应开口端间隔开。 每个橡胶块在其孔口件的相应端部的自由端处可抵靠,从而当缓冲装置受到过大的振动负载时,封闭相应开口端的孔口。