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1.发明授权Methods compositions and compound assays for inhibiting amyloid-beta protein production 有权用于抑制淀粉样蛋白β蛋白生产的方法组合物和化合物测定法公开(公告)号：US07910320B2
公开(公告)日：2011-03-22
申请号：US12190888
申请日：2008-08-13
IPC分类号： G01N33/53 , G01N33/542 , G01N33/566 , G01N33/567 , C12P21/00 , C12P21/06 , C12Q1/66
CPC分类号： C12Q1/37 , G01N33/566 , G01N33/6896 , G01N2333/4709 , G01N2333/726 , G01N2500/00 , G01N2800/2821
摘要： A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
摘要翻译： 鉴定抑制细胞中淀粉样蛋白β前体蛋白加工的化合物的方法，包括使测试化合物与GPCR多肽或其片段接触，并测量与淀粉状蛋白-β肽的产生相关的化合物-GPCR性质。 该方法的细胞测定法测量包括第二信使和/或淀粉样蛋白β肽水平的指标。 包括有效的淀粉样蛋白-β前体加工抑制量的GPCR表达抑制剂的治疗方法和药物组合物可用于治疗涉及认知障碍的疾病如阿尔茨海默病。
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2.发明申请Methods, Compositions and Compound Assays for Inhibiting Amyloid-Beta Protein production 有权用于抑制淀粉样蛋白β蛋白生产的方法，组合物和化合物分析公开(公告)号：US20090005262A1
公开(公告)日：2009-01-01
申请号：US12190888
申请日：2008-08-13
CPC分类号： C12Q1/37 , G01N33/566 , G01N33/6896 , G01N2333/4709 , G01N2333/726 , G01N2500/00 , G01N2800/2821
摘要： A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
摘要翻译： 鉴定抑制细胞中淀粉样蛋白β前体蛋白加工的化合物的方法，包括使测试化合物与GPCR多肽或其片段接触，并测量与淀粉状蛋白-β肽的产生相关的化合物-GPCR性质。 该方法的细胞测定法测量包括第二信使和/或淀粉样蛋白β肽水平的指标。 包括有效的淀粉样蛋白-β前体加工抑制量的GPCR表达抑制剂的治疗方法和药物组合物可用于治疗涉及认知障碍的疾病如阿尔茨海默病。
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3.发明授权Methods for identifying a compound that inhibits the procession of amyloid-beta protein production in a mammalian cell expressing APP and overexpressing a G-protein coupled receptor in the cell 失效用于鉴定抑制表达APP的哺乳动物细胞中淀粉样蛋白-β蛋白产生的过程并在细胞中过表达G蛋白偶联受体的化合物的方法公开(公告)号：US07429459B2
公开(公告)日：2008-09-30
申请号：US11110274
申请日：2005-04-20
IPC分类号： G01N33/53 , G01N33/542 , G01N33/566 , C12P21/06 , C12P21/04
CPC分类号： C12Q1/37 , G01N33/566 , G01N33/6896 , G01N2333/4709 , G01N2333/726 , G01N2500/00 , G01N2800/2821
摘要： A method for identifying compounds that inhibit amyloidal-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloidal-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods,and pharmaceutical compositions including effective amyloidal-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
摘要翻译： 用于鉴定抑制细胞中淀粉样蛋白β前体蛋白加工的化合物的方法，包括使测试化合物与GPCR多肽或其片段接触，并测量与淀粉样蛋白-β肽的产生相关的化合物-GPCR性质。 该方法的细胞测定法测量包括第二信使和/或淀粉样蛋白β肽水平的指标。 包括有效淀粉样蛋白β前体加工抑制量的GPCR表达抑制剂的治疗方法和药物组合物可用于治疗涉及认知障碍的疾病如阿尔茨海默病。
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