公开(公告)号：US20110230439A1

公开(公告)日：2011-09-22

申请号：US13124537

申请日：2009-10-16

申请人： Kerr Anderson ,  David R. Albers ,  Scott A. Young ,  Wallace H. Yokoyama

发明人： Kerr Anderson ,  David R. Albers ,  Scott A. Young ,  Wallace H. Yokoyama

IPC分类号： A61K31/717 ,  A61P3/06

CPC分类号： A23L33/24 ,  A23L29/262 ,  A23L33/12

摘要： Provided are food products comprising at least 0.5 g of trans fatty acid per serving and at least 1.33 weight percent of one or more water-soluble cellulose derivatives, based on the total weight of the food product, methods of ameliorating the harmful effects of trans fatty acids on a mammal that has consumed trans fatty acids, and methods of reducing the amount of trans fatty acids capable of being absorbed by a mammal ingesting a trans fatty acid containing food product.

摘要翻译： 提供的食品包含每份至少0.5g的反式脂肪酸和至少1.33％（重量）的一种或多种水溶性纤维素衍生物，基于食品的总重量，改善反式脂肪的有害作用的方法 已经消耗反式脂肪酸的哺乳动物上的酸，以及减少能够被哺乳动物摄入含反式脂肪酸的食品吸收的反式脂肪酸的量的方法。

公开(公告)号：US06737060B2

公开(公告)日：2004-05-18

申请号：US09999021

申请日：2001-10-31

申请人： W. H. Kerr Anderson ,  Philip R. Tempest ,  Frank J. Carr ,  William J. Harris ,  Kathryn Armour

发明人： W. H. Kerr Anderson ,  Philip R. Tempest ,  Frank J. Carr ,  William J. Harris ,  Kathryn Armour

IPC分类号： A61K39395

CPC分类号： C07K16/30 ,  C07K2317/24

摘要： Novel humanized monoclonal antibodies, humanized antibody fragments, and derivatives thereof which specifically bind TAG-72 are provided as well as methods for their manufacture. These humanized antibodies are useful in the treatment of cancers which express TAG-72 as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells which express TAG-72.

公开(公告)号：US06333405B1

公开(公告)日：2001-12-25

申请号：US09672609

申请日：2000-09-28

申请人： W. H. Kerr Anderson ,  Philip R. Tempest ,  Frank J. Carr ,  William J. Harris ,  Kathryn Armour

发明人： W. H. Kerr Anderson ,  Philip R. Tempest ,  Frank J. Carr ,  William J. Harris ,  Kathryn Armour

IPC分类号： C07H2104

CPC分类号： C07K16/3007 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00

摘要： Novel humanized monoclonal antibodies, fragments or derivatives thereof which specifically bind carcinoembryonic antigen (CEA) are provided as well as methods for their manufacture. These humanized antibodies are useful in the treatment of cancers which express CEA as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells which express CEA.

摘要翻译： 提供特异性结合癌胚抗原（CEA）的新型人源化单克隆抗体，其片段或衍生物以及其制备方法。 这些人源化抗体可用于治疗表达CEA以及诊断目的的癌症，例如用于表达CEA的肿瘤或癌细胞的体内成像。

公开(公告)号：US6051225A

公开(公告)日：2000-04-18

申请号：US40687

申请日：1993-03-31

申请人： Peter S. Mezes ,  Brian B. Gourlie ,  Mark W. Rixon ,  Jeffrey Schlom ,  Donald A. Kaplan ,  W. H. Kerr Anderson

发明人： Peter S. Mezes ,  Brian B. Gourlie ,  Mark W. Rixon ,  Jeffrey Schlom ,  Donald A. Kaplan ,  W. H. Kerr Anderson

IPC分类号： A61K38/00 ,  A61K47/48 ,  A61K51/10 ,  A61P35/00 ,  C07K16/30 ,  C07K16/46 ,  C12N15/14 ,  C12P21/08 ,  A61K39/375

CPC分类号： A61K47/48669 ,  A61K51/1087 ,  C07K16/30 ,  C07K16/462 ,  A61K2123/00 ,  A61K38/00 ,  C07K2317/24 ,  C07K2319/00

摘要： This invention concerns a family of chimeric antibodies with high affinities to a high molecular weight, tumor-associated sialylated glycoprotein antigen (TAG-72) of human origin. These antibodies have (1) high affinity animal V.sub.H and V.sub.L sequences which mediate TAG-72 binding and (2) human C.sub.H and C.sub.L regions. They are thought to produce significantly fewer side-effects when administered to human patients by virtue of their human C.sub.H and C.sub.L antibody domains. The nucleotide and amino acid sequences of V.sub.H .alpha.TAG V.sub.H, CC46 V.sub.H, CC49.sub.H, CC83 V.sub.H, and CC92 V.sub.H, and CC49.sub.L, CC83 V.sub.L, and CC92 V.sub.L idiotype sequences are disclosed, as well as in vivo methods of treatment and diagnostic assay using these chimeric antibodies.

摘要翻译： 本发明涉及对人类高分子量肿瘤相关唾液酸化糖蛋白抗原（TAG-72）具有高亲和力的嵌合抗体家族。 这些抗体具有（1）介导TAG-72结合的高亲和力动物VH和VL序列，（2）人CH和CL区。 据认为，由于其人类CH和CL抗体结构域，当向人类患者施用时，它们会产生显着较少的副作用。 公开了VHαTAG VH，CC46VH，CC49H，CC83VV和CC92VV和CC49L，CC83VL和CC92VV独特型序列的核苷酸和氨基酸序列，以及体内使用的治疗和诊断测定方法 这些嵌合抗体。

公开(公告)号：US20100331278A1

公开(公告)日：2010-12-30

申请号：US12775180

申请日：2010-05-06

申请人： W. H. Kerr Anderson ,  Shao-Ching Hung ,  William T. Stott ,  Maciej Turowski ,  Wallace H. Yokoyama ,  Scott A. Young

发明人： W. H. Kerr Anderson ,  Shao-Ching Hung ,  William T. Stott ,  Maciej Turowski ,  Wallace H. Yokoyama ,  Scott A. Young

IPC分类号： A61K31/717 ,  C08B11/08 ,  A61P3/04 ,  A61P3/00 ,  A61P3/06 ,  A61P3/10

CPC分类号： A61K31/717 ,  A23L2/52 ,  A23L33/24 ,  A23V2002/00 ,  A23V2200/326 ,  A23V2200/332 ,  A23V2200/322 ,  A23V2250/5108

摘要： Described are an oral ingestion form comprising cationic hydroxyethylcellulose, and methods of using the same in prevention and treatment of metabolic disorders.

摘要翻译： 描述了包含阳离子羟乙基纤维素的口服摄取形式，及其用于预防和治疗代谢紊乱的方法。

公开(公告)号：US06737061B2

公开(公告)日：2004-05-18

申请号：US09999025

申请日：2001-10-31

申请人： W. H. Kerr Anderson ,  Philip R. Tempest ,  Frank J. Carr ,  William J. Harris ,  Kathryn Armour

发明人： W. H. Kerr Anderson ,  Philip R. Tempest ,  Frank J. Carr ,  William J. Harris ,  Kathryn Armour

IPC分类号： A61K39395

CPC分类号： C07K16/30 ,  C07K2317/24

摘要： Novel humanized monoclonal antibodies, humanized antibody fragments, and derivatives thereof which specifically bind TAG-72 are provided as well as methods for their manufacture. These humanized antibodies are useful in the treatment of cancers which express TAG-72 as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells which express TAG-72.

摘要翻译： 提供了特异性结合TAG-72的新型人源化单克隆抗体，人源化抗体片段及其衍生物及其制备方法。 这些人源化抗体可用于治疗表达TAG-72以及用于诊断目的的癌症，例如用于体内成像肿瘤或表达TAG-72的癌细胞。

公开(公告)号：US06417337B1

公开(公告)日：2002-07-09

申请号：US09025403

申请日：1998-02-18

申请人： W. H. Kerr Anderson ,  Philip R. Tempest ,  Frank J. Carr ,  William J. Harris ,  Kathryn Armour

发明人： W. H. Kerr Anderson ,  Philip R. Tempest ,  Frank J. Carr ,  William J. Harris ,  Kathryn Armour

IPC分类号： A07K1630

CPC分类号： C07K16/3007 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00

摘要： Novel humanized monoclonal antibodies, fragments or derivatives thereof which specifically bind carcinoembryonic antigen (CEA) are provided as well as methods for their manufacture. These humanized antibodies are useful in the treatment of cancers which express CEA as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells which express CEA.

摘要翻译： 提供特异性结合癌胚抗原（CEA）的新型人源化单克隆抗体，其片段或衍生物以及其制备方法。 这些人源化抗体可用于治疗表达CEA以及诊断目的的癌症，例如用于表达CEA的肿瘤或癌细胞的体内成像。

公开(公告)号：US06348581B1

公开(公告)日：2002-02-19

申请号：US09025203

申请日：1998-02-18

申请人： W. H. Kerr Anderson ,  Philip R. Tempest ,  Frank J. Carr ,  William J. Harris ,  Kathryn Armour

发明人： W. H. Kerr Anderson ,  Philip R. Tempest ,  Frank J. Carr ,  William J. Harris ,  Kathryn Armour

IPC分类号： A61K39395

CPC分类号： C07K16/30 ,  C07K2317/24

摘要： Novel humanized monoclonal antibodies, humanized antibody fragments, and derivatives thereof which specifically bind TAG-72 are provided as well as methods for their manufacture. These humanized antibodies are useful in the treatment of cancers which express TAG-72 as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells which express TAG-72.

摘要翻译： 提供了特异性结合TAG-72的新型人源化单克隆抗体，人源化抗体片段及其衍生物及其制备方法。 这些人源化抗体可用于治疗表达TAG-72以及用于诊断目的的癌症，例如用于体内成像肿瘤或表达TAG-72的癌细胞。

公开(公告)号：US06753420B2

公开(公告)日：2004-06-22

申请号：US09998817

申请日：2001-10-31

申请人： W. H. Kerr Anderson ,  Philip R. Tempest ,  Frank J. Carr ,  William J. Harris ,  Kathryn Armour

发明人： W. H. Kerr Anderson ,  Philip R. Tempest ,  Frank J. Carr ,  William J. Harris ,  Kathryn Armour

IPC分类号： C07H2104

CPC分类号： C07K16/30 ,  C07K2317/24

摘要： Novel humanized monoclonal antibodies, humanized antibody fragments, and derivatives thereof which specifically bind TAG-72 are provided as well as methods for their manufacture. These humanized antibodies are useful in the treatment of cancers which express TAG-72 as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells which express TAG-72.

摘要翻译： 提供了特异性结合TAG-72的新型人源化单克隆抗体，人源化抗体片段及其衍生物及其制备方法。 这些人源化抗体可用于治疗表达TAG-72以及用于诊断目的的癌症，例如用于体内成像肿瘤或表达TAG-72的癌细胞。

公开(公告)号：US06753152B2

公开(公告)日：2004-06-22

申请号：US09999040

申请日：2001-10-31

申请人： W. H. Kerr Anderson ,  Philip R. Tempest ,  Frank J. Carr ,  William J. Harris ,  Kathryn Armour

发明人： W. H. Kerr Anderson ,  Philip R. Tempest ,  Frank J. Carr ,  William J. Harris ,  Kathryn Armour

IPC分类号： G01N3353

CPC分类号： C07K16/30 ,  C07K2317/24

摘要： Novel humanized monoclonal antibodies, humanized antibody fragments, and derivatives thereof which specifically bind TAG-72 are provided as well as methods for their manufacture. These humanized antibodies are useful in the treatment of cancers which express TAG-72 as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells which express TAG-72.

摘要翻译： 提供了特异性结合TAG-72的新型人源化单克隆抗体，人源化抗体片段及其衍生物及其制备方法。 这些人源化抗体可用于治疗表达TAG-72以及用于诊断目的的癌症，例如用于体内成像肿瘤或表达TAG-72的癌细胞。