公开(公告)号：US20060216770A1

公开(公告)日：2006-09-28

申请号：US11441644

申请日：2006-05-26

申请人： Kenneth Kasper ,  Henry Jeong ,  Dariush Davalian ,  Hshiou-tinh Liu ,  Paul Miller ,  Denise Williams

发明人： Kenneth Kasper ,  Henry Jeong ,  Dariush Davalian ,  Hshiou-tinh Liu ,  Paul Miller ,  Denise Williams

IPC分类号： G01N33/53 ,  C12N9/00 ,  C12N5/06 ,  C07K16/18

CPC分类号： A61K51/1093 ,  C07K16/1292 ,  Y10S436/815

摘要： An IgG1 λ monoclonal antibody to the immunosuppressive drug tacrolimus has improved properties. In particular, this monoclonal antibody, designated 1H6, has reduced cross-reactivity to several tacrolimus metabolites. This antibody is suitable for performance of immunoassays such as homogeneous immunoassays to detect or determine the presence or concentration of tacrolimus in samples such as blood samples. The invention further includes derivatives of tacrolimus derivatized at a non-binding portion of the molecule useful in immunizing antibody-producing animals and in producing such monoclonal antibodies, as well as labeled derivatives of tacrolimus useful as tacrolimus analogues in such assays. The invention further includes immunoassay methods for the detection of tacrolimus and test kits useful in performing such immunoassays.

公开(公告)号：US20110088311A1

公开(公告)日：2011-04-21

申请号：US12885693

申请日：2010-09-20

申请人： Donald Bower ,  Philip Catania ,  Edward Johnson ,  Kenneth Kasper ,  John J. Rusek ,  Jonathon Ziulkowski

发明人： Donald Bower ,  Philip Catania ,  Edward Johnson ,  Kenneth Kasper ,  John J. Rusek ,  Jonathon Ziulkowski

IPC分类号： C10L1/222 ,  C10L1/10 ,  C10L1/185 ,  C10L1/12 ,  C10L1/16

CPC分类号： C10L10/10 ,  C10G2300/301 ,  C10G2300/305 ,  C10L1/026 ,  C10L1/04 ,  C10L1/06 ,  C10L1/10 ,  C10L1/1258 ,  C10L1/14 ,  C10L1/1608 ,  C10L1/1881 ,  C10L1/231 ,  C10L2200/024 ,  C10L2200/0423 ,  C10L2200/043 ,  C10L2200/0469 ,  C10L2230/22 ,  C10L2270/023 ,  Y02E50/13 ,  Y02P30/20 ,  Y02T50/678

摘要： A motor fuel providing higher gas mileage comprising gasoline produced from petroleum and from about 1 to 30 wt % of mesitylene. This fuel can advantageously contain conventional additives used in gasoline. The use of mesitylene in gasoline blend yields a fuel blend with a higher research octane number and motor octane number. In addition, an improved jet fuel is provided, having from 1-10 wt % biomass-derived mesitylene added thereto, having improved carbon emission characteristics while maintaining required specifications. Further, an improved bio-fuel is provided, which may function as a replacement for conventional Jet A/JP-8 fuel and has lowered carbon emission specifications, the bio-fuel comprised of 75-90 wt % synthetic parafinnic kerosene (SPK) and 10-25 wt % mesitylene.

摘要翻译： 提供更高的燃油里程的汽油燃料包括由石油产生的汽油和约1至30重量％的均三甲苯。 该燃料可有利地含有用于汽油的常规添加剂。 在汽油混合物中使用均三甲苯产生具有较高研究辛烷值和马达辛烷值的燃料混合物。 此外，提供改进的喷气燃料，其具有1-10重量％的生物质衍生的均三甲苯，其具有改善的碳排放特性，同时保持所需的规格。 此外，提供了改进的生物燃料，其可以用作常规喷射A / JP-8燃料的替代物，并且具有降低的碳排放规格，包含75-90重量％的合成路标煤油（SPK）的生物燃料和 10-25重量％均三甲苯。