公开(公告)号：US07287390B2

公开(公告)日：2007-10-30

申请号：US10277909

申请日：2002-10-22

申请人： Kenneth Bolam

发明人： Kenneth Bolam

IPC分类号： B01D8/00 ,  F25B21/00 ,  F25B49/00 ,  G01N1/00 ,  G01N24/00

CPC分类号： G01R33/282 ,  A61K49/1815 ,  Y10T436/10 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25875

摘要： Hyperpolarizers for producing polarized noble gases can include: (a) a control module configured to direct the operation of a hyperpolarizer to produce polarized noble gas via spin-exchange interactions between a noble gas and an alkali metal; (b) at least one optical pumping module including an optical pumping cell operably associated with the control module; (c) a dispensing system operably associated with the control module and the optical pumping module to dispense meted volumes of polarized gas from the hyperpolarizer; and (d) a fluid distribution system operably associated with the control module, the optical pumping module, and the dispensing system, such that, in response to commands transmitted from the control module, the fluid distribution system operates to automatically direct purge gas into and out of a gas travel path that extends from the control module to the optical pumping cell prior to commencing the spin-exchange interactions in the optical pumping cell, then to receive unpolarized gas and direct it to travel in the gas travel path to the optical pumping cell, and, following the spin-exchange interactions, to automatically direct polarized gas from the optical pumping cell into a polarized gas exit travel path to the dispensing system. Related methods and computer program products as well as particular embodiments of optical pumping modules, thermal oven assemblies, and manifold blocks are also described.

摘要翻译： 用于生产极化惰性气体的超极化剂可以包括：（a）控制模块，其配置为引导超极化器的操作，以通过惰性气体和碱金属之间的自旋交换相互作用产生极性惰性气体; （b）至少一个光泵送模块，其包括与所述控制模块可操作地相关联的光泵浦单元; （c）与所述控制模块和所述光泵送模块可操作地相关联的分配系统，以从所述超极化器分配经测量的极化气体体积; 以及（d）与所述控制模块，所述光泵送模块和所述分配系统可操作地相关联的流体分配系统，使得响应于从所述控制模块传送的命令，所述流体分配系统操作以自动地将吹扫气体引导进入和 在开始光泵浦单元之间的自旋交换相互作用之前从控制模块延伸到光泵浦单元的气体行进路径中，然后接收非偏振气体并引导其在气体行进路径中行进到光泵浦 并且在自旋交换相互作用之后，自动地将来自光学泵浦单元的极化气体引导到分配系统的极化气体出口行进路径中。 还描述了相关方法和计算机程序产品以及光泵模块，热烘箱组件和歧管块的特定实施例。

公开(公告)号：US20060149176A1

公开(公告)日：2006-07-06

申请号：US11338205

申请日：2006-01-24

申请人： Kenneth Bolam ,  James Borgen

发明人： Kenneth Bolam ,  James Borgen

IPC分类号： A61H9/00

CPC分类号： A61H9/0078 ,  A61H2201/5002 ,  A61H2201/5007 ,  A61H2205/10 ,  Y10S601/21

摘要： A controller for a gradient sequential compression system is provided for inflating a plurality of inflatable chambers of one or more compression sleeves according to several different modes of operation. A mode of operation may define the number and selection of chambers to be inflated, the pressurization levels, the pressurization time, or the sequence of chamber inflation. To enable the controller to automatically perform a designated mode of operation based on the type of compression sleeve connected, a new and improved connecting device is provided. An indicator on an interface connector associates a predetermined mode of operation with the interface connector. A sensor associated with a complementary connector identifies the mode of operation associated with the interface connector. It is contemplated that the universal connecting device can be used for any type of system, not just controllers for a gradient sequential compression system.

摘要翻译： 梯度顺序压缩系统的控制器被提供用于根据若干不同的操作模式对一个或多个压缩套筒的多个可充气室进行充气。 操作模式可以限定要充气的室的数量和选择，加压水平，加压时间或室充气的顺序。 为了使控制器能够根据连接的压缩套筒的类型自动执行指定的操作模式，提供了一种新的改进的连接装置。 接口连接器上的指示器将预定操作模式与接口连接器相关联。 与互补连接器相关联的传感器标识与接口连接器相关联的操作模式。 可以想到，通用连接装置可以用于任何类型的系统，而不仅仅是用于梯度顺序压缩系统的控制器。

公开(公告)号：US20080000471A1

公开(公告)日：2008-01-03

申请号：US11850786

申请日：2007-09-06

申请人： Kenneth Bolam ,  James Borgen

发明人： Kenneth Bolam ,  James Borgen

IPC分类号： A61M16/00

CPC分类号： A61M16/12 ,  A61M16/0858 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2202/0275 ,  A61M2202/0291

摘要： Ventilator systems include: (a) a mass flow controller; (b) a gas delivery valve in communication with the mass flow controller and configured to selectively dispense a plurality of different gases to a subject; (c) a first gas source in fluid communication with the gas delivery valve; (d) a second gas source in fluid communication with the gas delivery valve; (e) a first pressure sensor located upstream of the gas delivery valve; (f) a second pressure sensor located downstream of the gas delivery valve; and (g) a controller operatively associated with the first and second pressure sensors and the mass flow controller, the controller comprising computer program code that monitors the pressures measured by the first and second pressure sensors and automatically dynamically adjusts the flow rate of the mass flow controller.

摘要翻译： 呼吸机系统包括：（a）质量流量控制器; （b）气体输送阀，其与所述质量流量控制器连通并且被配置为向对象选择性地分配多种不同的气体; （c）与气体输送阀流体连通的第一气体源; （d）与所述气体输送阀流体连通的第二气体源; （e）位于气体输送阀上游的第一压力传感器; （f）位于气体输送阀下游的第二压力传感器; 和（g）与第一和第二压力传感器和质量流量控制器可操作地相关联的控制器，所述控制器包括监测由第一和第二压力传感器测量的压力的计算机程序代码，并且自动地动态调整质量流量 控制器。

公开(公告)号：US08035376B2

公开(公告)日：2011-10-11

申请号：US11856963

申请日：2007-09-18

申请人： Kenneth Bolam

发明人： Kenneth Bolam

IPC分类号： G01V3/00

CPC分类号： G01R33/282 ,  A61K49/1815 ,  Y10T436/10 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25875

摘要： A method of providing polarized noble gas for NMR or MRI applications incorporates a control module, a plurality of optical pumping modules each including an optical pumping cell operably associated with the control module; a plurality of dispensing systems, one for each optical pumping module wherein each dispensing system is operably associated with the control module and the its associated optical pumping module to dispense meted volumes of polarized gas from the hyperpolarizer; the optical pumping modules, and the dispensing systems, where a noble gas is directed to a selected one of the optical pumping modules, polarized and dispensed by the associated dispensing system.

摘要翻译： 提供用于NMR或MRI应用的偏振惰性气体的方法包括控制模块，多个光学泵浦模块，每个光学泵浦模块包括可操作地与控制模块相关联的光学泵浦单元; 多个分配系统，一个用于每个光学泵送模块，其中每个分配系统可操作地与控制模块及其相关联的光学泵送模块相关联，以分配来自超极化器的体积的极化气体; 光学泵送模块和分配系统，其中惰性气体被引导到所选择的一个光学泵送模块，由相关联的分配系统偏振和分配。

公开(公告)号：US07275540B2

公开(公告)日：2007-10-02

申请号：US10828824

申请日：2004-04-21

申请人： Kenneth Bolam ,  James Borgen

发明人： Kenneth Bolam ,  James Borgen

IPC分类号： A61M16/00 ,  A62B7/00 ,  F16K31/02 ,  F16K11/00 ,  G05D11/02

CPC分类号： A61M16/12 ,  A61M16/0858 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2202/0275 ,  A61M2202/0291

摘要： Ventilator systems include: (a) a mass flow controller; (b) a gas delivery valve in communication with the mass flow controller and configured to selectively dispense a plurality of different gases to a subject; (c) a first gas source in fluid communication with the gas delivery valve; (d) a second gas source in fluid communication with the gas delivery valve; (e) a first pressure sensor located upstream of the gas delivery valve; (f) a second pressure sensor located downstream of the gas delivery valve; and (g) a controller operatively associated with the first and second pressure sensors and the mass flow controller, the controller comprising computer program code that monitors the pressures measured by the first and second pressure sensors and automatically dynamically adjusts the flow rate of the mass flow controller.

摘要翻译： 呼吸机系统包括：（a）质量流量控制器; （b）气体输送阀，其与所述质量流量控制器连通并且被配置为向对象选择性地分配多种不同的气体; （c）与气体输送阀流体连通的第一气体源; （d）与所述气体输送阀流体连通的第二气体源; （e）位于气体输送阀上游的第一压力传感器; （f）位于气体输送阀下游的第二压力传感器; 和（g）与第一和第二压力传感器和质量流量控制器可操作地相关联的控制器，所述控制器包括监测由第一和第二压力传感器测量的压力的计算机程序代码，并且自动地动态调整质量流量 控制器。

公开(公告)号：US20070144523A1

公开(公告)日：2007-06-28

申请号：US10547436

申请日：2004-02-25

申请人： Kenneth Bolam ,  James Davidson ,  James Borgen

发明人： Kenneth Bolam ,  James Davidson ,  James Borgen

IPC分类号： A62B9/02

CPC分类号： G01R33/28 ,  A62B9/02 ,  F16K11/0712 ,  F16K31/122 ,  G01R33/5601

摘要： Methods, systems, assemblies, computer program products and devices deliver hyperpolarized gas by: (a) providing a gas delivery valve with at least one gas flow path therein, the valve comprising a valve body and at least one spool held in the valve body; (b) transmitting a pilot command fluid pulse signal to the at least one spool to introduce pressure onto the spool to force the spool to translate an actuation distance in the valve body; and (c) opening and/or closing the at least one gas flow path in response to the transmitted signal to deliver hyperpolarized gas to a subject.

摘要翻译： 方法，系统，组件，计算机程序产品和装置通过以下方式提供超极化气体：（a）提供具有至少一个气体流路的气体输送阀，所述阀包括阀体和至少一个保持在阀体中的阀芯; （b）将先导指令流体脉冲信号传送到所述至少一个阀芯以将压力引导到所述阀芯上以迫使所述阀芯平移阀体中的致动距离; 和（c）响应于所传输的信号打开和​​/或关闭所述至少一个气体流动路径，以将超极化气体输送到对象。

公开(公告)号：US20060269614A1

公开(公告)日：2006-11-30

申请号：US10542293

申请日：2004-01-20

申请人： Ian Nelson ,  Stephen Kadlecek ,  John Nouls ,  Edward Karwacki ,  Kenneth Bolam ,  Jim Davidson

发明人： Ian Nelson ,  Stephen Kadlecek ,  John Nouls ,  Edward Karwacki ,  Kenneth Bolam ,  Jim Davidson

IPC分类号： H01J27/00 ,  A61K33/00

CPC分类号： G01R33/282 ,  A61K33/00 ,  F04B17/00 ,  F04B43/06 ,  F04B45/043 ,  F04B45/053 ,  F04B45/061

摘要： Methods, systems, assemblies, computer program products and devices produce hyperpolarized gas by: (a) providing a plurality of cells (30), each having a respective quantity of target gas held therein; (b) polarizing the target gas in and/or from the cells in a desired order to provide separate batches of polarized gas; and (c) repolarizing the previously polarized target gas held in least one of the cells when the polarization level falls below a predetermined value.

摘要翻译： 方法，系统，组件，计算机程序产品和设备通过以下方式产生超极化气体：（a）提供多个单元（30），每个单元具有保存在其中的相应数量的目标气体; （b）以期望的顺序使目标气体在电池内和/或从电池偏振，以提供单独的批次的极化气体; 和（c）当偏振电平降低到预定值以下时，将至少一个电池中保留的先前极化的目标气体复极化。

公开(公告)号：US07610914B2

公开(公告)日：2009-11-03

申请号：US11850786

申请日：2007-09-06

申请人： Kenneth Bolam ,  James Borgen

发明人： Kenneth Bolam ,  James Borgen

IPC分类号： A61M16/00 ,  A62B7/00 ,  F16K31/02

CPC分类号： A61M16/12 ,  A61M16/0858 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2202/0275 ,  A61M2202/0291

摘要： Ventilator systems include: (a) a mass flow controller; (b) a gas delivery valve in communication with the mass flow controller and configured to selectively dispense a plurality of different gases to a subject; (c) a first gas source in fluid communication with the gas delivery valve; (d) a second gas source in fluid communication with the gas delivery valve; (e) a first pressure sensor located upstream of the gas delivery valve; (f) a second pressure sensor located downstream of the gas delivery valve; and (g) a controller operatively associated with the first and second pressure sensors and the mass flow controller, the controller comprising computer program code that monitors the pressures measured by the first and second pressure sensors and automatically dynamically adjusts the flow rate of the mass flow controller.

摘要翻译： 呼吸机系统包括：（a）质量流量控制器; （b）气体输送阀，其与所述质量流量控制器连通并且被配置为向对象选择性地分配多种不同的气体; （c）与气体输送阀流体连通的第一气体源; （d）与所述气体输送阀流体连通的第二气体源; （e）位于气体输送阀上游的第一压力传感器; （f）位于气体输送阀下游的第二压力传感器; 和（g）与第一和第二压力传感器和质量流量控制器可操作地相关联的控制器，所述控制器包括监测由第一和第二压力传感器测量的压力的计算机程序代码，并且自动地动态调整质量流量 控制器。

公开(公告)号：US20080006265A1

公开(公告)日：2008-01-10

申请号：US11856868

申请日：2007-09-18

申请人： Kenneth Bolam

发明人： Kenneth Bolam

IPC分类号： A61M16/10

CPC分类号： G01R33/282 ,  A61K49/1815 ,  Y10T436/10 ,  Y10T436/208339 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25875

摘要： Modular expandable hyperpolarizers include a central control module and at least one optical pumping module that can be expandable to a plurality of optical pumping modules that can be separately operated depending on the capacity demands at the production site (hospital, clinic and the like). Methods for producing blended polarized gas products include introducing a pre-packaged pre-mixed amount of a polarizer-ready blend of unpolarized gas. Methods for producing the polarized gas can be carried out at the point of use site and the production run according to patient load. Other methods consider the patient load and automatically schedule the hyperpolarizer to yield the desired polarized gas doses to support the patient and/or MRI/NMR equipment schedule.

摘要翻译： 模块化可扩展超极化器包括中央控制模块和至少一个可以扩展到多个光泵装置的光泵模块，其可根据生产现场（医院，诊所等）的容量要求分开运行。 制备混合极化气体产品的方法包括引入预先包装的预混合量的偏光剂 - 未偏振气体的混合物。 用于生产极化气体的方法可以在使用地点进行，根据患者负荷进行生产。 其他方法考虑患者负荷并自动安排超极化剂以产生所需的极化气体剂量以支持患者和/或MRI / NMR设备进度。

公开(公告)号：US07287391B2

公开(公告)日：2007-10-30

申请号：US10277911

申请日：2002-10-22

申请人： Kenneth Bolam

发明人： Kenneth Bolam

IPC分类号： B01D8/00 ,  F25B21/00 ,  F25B49/00 ,  G01N1/00 ,  G01N24/00

CPC分类号： G01R33/282 ,  A61K49/1815 ,  Y10T436/10 ,  Y10T436/208339 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25875

摘要： Modular expandable hyperpolarizers include a central control module and at least one optical pumping module that can be expandable to a plurality of optical pumping modules that can be separately operated depending on the capacity demands at the production site (hospital, clinic and the like). Methods for producing blended polarized gas products include introducing a pre-packaged pre-mixed amount of a polarizer-ready blend of unpolarized gas. Methods for producing the polarized gas can be carried out at the point of use site and the production run according to patient load. Other methods consider the patient load and automatically schedule the hyperpolarizer to yield the desired polarized gas doses to support the patient and/or MRI/NMR equipment schedule.

摘要翻译： 模块化可扩展超极化器包括中央控制模块和至少一个可以扩展到多个光泵装置的光泵模块，其可根据生产现场（医院，诊所等）的容量要求分开运行。 制备混合极化气体产品的方法包括引入预先包装的预混合量的偏光剂 - 未偏振气体的混合物。 用于生产极化气体的方法可以在使用地点进行，根据患者负荷进行生产。 其他方法考虑患者负荷并自动安排超极化剂以产生所需的极化气体剂量以支持患者和/或MRI / NMR设备进度。