-
公开(公告)号：US20140350034A1
公开(公告)日：2014-11-27
申请号：US14371458
申请日：2013-01-25
Applicant: Trixi Brandl , Stefanie Flohr , Christian Markert , Kenji Namoto , Bernard Pirard , Martin Renatus
Inventor： Trixi Brandl , Stefanie Flohr , Christian Markert , Kenji Namoto , Bernard Pirard , Martin Renatus
IPC: C07D498/04 , A61K31/519 , C07D405/12 , A61K31/443 , C07D487/04 , A61K31/4436 , C07D401/12 , A61K31/4439 , C07D213/73 , A61K31/44 , C07D495/04 , C07D409/12
CPC classification number: C07D498/04 , A61K31/44 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/519 , A61K45/06 , C07D213/73 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D487/04 , C07D495/04 , A61K2300/00
Abstract: The invention relates to compound of the formula (I) in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.
Abstract translation: 本发明涉及式（I）化合物，其中取代基如说明书中所定义; 以游离形式或盐形式; 作为其制备，用作药物和包含它的药物。
-
公开(公告)号：US08097617B2
公开(公告)日：2012-01-17
申请号：US12295549
申请日：2007-03-29
Applicant: Daniel Kaspar Baeschlin , Nils Ostermann , Francois Gessier , Finton Sirockin , Kenji Namoto
Inventor： Daniel Kaspar Baeschlin , Nils Ostermann , Francois Gessier , Finton Sirockin , Kenji Namoto
IPC: A61K31/437 , A61K31/5377 , A61K31/541 , C07D471/04 , C07D413/14 , C07D279/12 , A61P9/00 , A61P3/00 , A61P25/00
CPC classification number: C07D519/00 , C07D471/04
Abstract: New compounds of the Formula (I): for the treatment of non-insulin-dependent diabetes mellitus.
Abstract translation: 式（I）的新化合物：用于治疗非胰岛素依赖性糖尿病。
-
公开(公告)号：US07888351B2
公开(公告)日：2011-02-15
申请号：US12296792
申请日：2007-04-10
Applicant: Daniel Kaspar Baeschlin , Garry Fenton , Kenji Namoto , Nils Ostermann , Richard Sedrani , Finton Sirockin
Inventor： Daniel Kaspar Baeschlin , Garry Fenton , Kenji Namoto , Nils Ostermann , Richard Sedrani , Finton Sirockin
IPC: C07D279/12 , C07D237/08 , C07D233/96 , C07D241/12 , C07D295/104 , C07D211/18 , C07D211/22 , C07D211/24 , C07D221/22 , C07D213/70 , C07D221/04
CPC classification number: C07D211/96 , C07D211/26 , C07D471/08
Abstract: The present invention relates to compounds of the formula; and their use in therapy.
Abstract translation: 本发明涉及下式的化合物： 及其在治疗中的应用。
-
公开(公告)号：US20090281069A1
公开(公告)日：2009-11-12
申请号：US12296792
申请日：2007-04-10
Applicant: Daniel Kaspar Baeschlin , Garry Fenton , Kenji Namoto , Nils Ostermann , Richard Sedrani , Finton Sirockin
Inventor： Daniel Kaspar Baeschlin , Garry Fenton , Kenji Namoto , Nils Ostermann , Richard Sedrani , Finton Sirockin
IPC: A61K31/43 , C07D209/52 , A61K31/403 , A61K31/497 , C07D403/12 , C07D413/12 , A61K31/5377 , A61K31/445 , C07D211/26
CPC classification number: C07D211/96 , C07D211/26 , C07D471/08
Abstract: The present invention relates to compounds of the formula; and their use in therapy.
Abstract translation: 本发明涉及下式的化合物： 及其在治疗中的应用。
-
公开(公告)号：US20120077787A1
公开(公告)日：2012-03-29
申请号：US13311949
申请日：2011-12-06
Applicant: Daniel Kaspar Baeschlin , Nils OSTERMANN , Francois GESSIER , Finton SIROCKIN , Kenji NAMOTO
Inventor： Daniel Kaspar Baeschlin , Nils OSTERMANN , Francois GESSIER , Finton SIROCKIN , Kenji NAMOTO
IPC: A61K31/437 , A61K31/5377 , A61K31/541 , A61K31/496 , C07D519/00 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/438 , A61P3/10 , A61P3/04 , A61P9/12 , A61P31/00 , A61P19/02 , A61P9/00 , A61P25/16 , A61P19/10 , A61P1/00 , A61P27/02 , A61P25/28 , A61P5/50 , A61P3/00 , A61P3/06 , A61P1/18 , A61P9/10 , A61P13/12 , A61P25/00 , A61P5/24 , A61P13/08 , A61K31/444 , A61K31/4545 , A61K31/56 , A61K31/568 , C07D471/04
CPC classification number: C07D519/00 , C07D471/04
Abstract: New compounds of the Formula (I): for the treatment of non-insulin-dependent diabetes mellitus.
Abstract translation: 式（I）的新化合物：用于治疗非胰岛素依赖性糖尿病。
-
Patent Agency Ranking
公开(公告)号：US07169930B2
公开(公告)日：2007-01-30
申请号：US10634537
申请日：2003-08-04
Applicant: Kyriacos C. Nicolaou , Andreas Ritzen , Kenji Namoto
Inventor： Kyriacos C. Nicolaou , Andreas Ritzen , Kenji Namoto
IPC: C07D417/06
CPC classification number: C07D405/06 , C07D407/06 , C07D417/06 , C07D493/04
Abstract: Designed epoxide and cyclopropane epothilone analogs with substituted side-chains are disclosed and characterized with respect to their biological activities against a series of human cancer cell lines. Among the several bioactive analogs, the epothilone B analog with a thiomethyl thiazole ring stands out as the most potent.
Abstract translation: 关于它们对一系列人癌细胞系的生物学活性，公开并表征了具有取代侧链的环氧化物和环丙烷埃坡霉素类似物。 在几种生物活性类似物中，具有硫代甲基噻唑环的埃坡霉素B类似物是最有效的。
-
公开(公告)号：US20060293527A1
公开(公告)日：2006-12-28
申请号：US11511610
申请日：2006-08-28
Applicant: Kyriacos Nicolaou , Andreas Ritzen , Kenji Namoto
Inventor： Kyriacos Nicolaou , Andreas Ritzen , Kenji Namoto
IPC: C07D417/02 , C07D405/02
CPC classification number: C07D405/06 , C07D407/06 , C07D417/06 , C07D493/04
Abstract: Designed epoxide and cyclopropane epothilone analogs with substituted side-chains are disclosed and characterized with respect to their biological activities against a series of human cancer cell lines. Among the several bioactive analogs, the epothilone B analog with a thiomethyl thiazole ring stands out as the most potent.
Abstract translation: 关于它们对一系列人癌细胞系的生物学活性，公开并表征了具有取代侧链的环氧化物和环丙烷埃坡霉素类似物。 在几种生物活性类似物中，具有硫代甲基噻唑环的埃坡霉素B类似物是最有效的。
-
8.发明授权公开(公告)号：US09290485B2
公开(公告)日：2016-03-22
申请号：US13194009
申请日：2011-07-29
Applicant: Trixi Brandl , Stefanie Flohr , Sebastian Kopec , Julie Lachal , Christian Markert , Kenji Namoto , Perle Nganga , Bernard Pirard , Martin Renatus , Richard Sedrani , Thomas Zoller
Inventor： Trixi Brandl , Stefanie Flohr , Sebastian Kopec , Julie Lachal , Christian Markert , Kenji Namoto , Perle Nganga , Bernard Pirard , Martin Renatus , Richard Sedrani , Thomas Zoller
IPC: C07D401/14 , C07D409/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/14
CPC classification number: C07D409/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/14
Abstract: The invention relates to compound of the formula I in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.
Abstract translation: 本发明涉及其中取代基如说明书中所定义的式I化合物; 以游离形式或盐形式; 作为其制备，用作药物和包含它的药物。
-
公开(公告)号：US20130012485A1
公开(公告)日：2013-01-10
申请号：US12520323
申请日：2007-12-20
Applicant: Daniel Kaspar Bäschlin , Richard Sedrani , Stefanie Flohr , Kenji Namoto , Nils Ostermann , Finton Sirockin , François Gessier , Garry Fenton , Mandy Christine Beswick , David Edward Clark , Bohdan Waszkowycz
Inventor： Daniel Kaspar Bäschlin , Richard Sedrani , Stefanie Flohr , Kenji Namoto , Nils Ostermann , Finton Sirockin , François Gessier , Garry Fenton , Mandy Christine Beswick , David Edward Clark , Bohdan Waszkowycz
IPC: A61K31/135 , A61K31/568 , A61K31/565 , C07C217/52 , C07D487/04 , A61K31/4985 , C07D211/08 , A61K31/451 , C07D295/135 , A61K31/495 , C07D401/04 , A61K31/4545 , A61K31/454 , C07D243/08 , A61K31/551 , C07D223/04 , A61K31/55 , A61K31/501 , C07D237/14 , A61K31/50 , A61P3/10 , A61P19/02 , A61P3/04 , A61P19/10 , A61P9/04 , A61P25/28 , A61P13/12 , A61P3/06 , A61P9/10 , A61P29/00 , A61P25/00 , A61P35/04 , A61P9/12 , A61P25/22 , A61P5/00 , C07C215/42
CPC classification number: C07C215/42 , C07C211/29 , C07C211/31 , C07C211/40 , C07C215/14 , C07C217/16 , C07C217/52 , C07C229/16 , C07C233/41 , C07C237/10 , C07C237/24 , C07C237/36 , C07C255/24 , C07C271/20 , C07C311/07 , C07C311/08 , C07C311/20 , C07C311/29 , C07C317/32 , C07C317/44 , C07C2601/02 , C07C2601/14 , C07D207/404 , C07D211/14 , C07D211/60 , C07D213/64 , C07D213/81 , C07D213/82 , C07D233/36 , C07D237/14 , C07D237/24 , C07D239/10 , C07D239/90 , C07D263/20 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/14 , C07D409/04 , C07D471/04 , C07D487/04
Abstract: Compounds of the formula (I) are provided: wherein V, W, X, Y, Z, R3, R4, R5, R6, R7 and m are as defined in the specification; and pharmaceutically acceptable salts and prodrugs thereof. The compounds may be useful in the treatment or prevention of various diseases and conditions in which dipeptidylpeptidase-IV (DPP-IV) is implicated.
Abstract translation: 提供式（I）化合物：其中V，W，X，Y，Z，R 3，R 4，R 5，R 6，R 7和m如说明书中所定义; 及其药学上可接受的盐和前药。 该化合物可用于治疗或预防涉及二肽基肽酶-IV（DPP-IV）的各种疾病和病症。
-
10.发明申请公开(公告)号：US20120035168A1
公开(公告)日：2012-02-09
申请号：US13194009
申请日：2011-07-29
Applicant: Trixi BRANDL , Stefanie FLOHR , Sebastian KOPEC , Julie LACHAL , Christian MARKERT , Kenji NAMOTO , Perle NGANGA , Bernard PIRARD , Martin RENATUS , Richard SEDRANI , Thomas ZOLLER
Inventor： Trixi BRANDL , Stefanie FLOHR , Sebastian KOPEC , Julie LACHAL , Christian MARKERT , Kenji NAMOTO , Perle NGANGA , Bernard PIRARD , Martin RENATUS , Richard SEDRANI , Thomas ZOLLER
IPC: A61K31/4439 , C07D401/14 , A61K31/506 , A61K31/4709 , C07D409/14 , C07D495/04 , A61K31/4365 , C07D413/14 , C07D471/04 , A61K31/444 , A61K31/536 , A61P3/10 , A61P27/02 , A61P9/12 , A61P27/12 , A61P9/10 , A61P25/00 , A61P31/00 , A61P25/16 , A61P25/08 , C07D401/12
CPC classification number: C07D409/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/14
Abstract: The invention relates to compound of the formula I in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.
Abstract translation: 本发明涉及式I化合物，其中取代基如说明书中所定义; 以游离形式或盐形式; 作为其制备，用作药物和包含它的药物。
-
-
-
-
-
-
-
-
-
Search Results
13
records
(took 0.026 seconds)
