公开(公告)号：US08524861B2

公开(公告)日：2013-09-03

申请号：US10586416

申请日：2005-02-28

申请人： Curtis Dobson ,  Keith Alan Crutcher

发明人： Curtis Dobson ,  Keith Alan Crutcher

IPC分类号： C07K7/08

CPC分类号： A61K38/1709 ,  Y02A50/469 ,  Y02A50/481

摘要： The invention relates to polypeptides, comprising repeats of peptides derived from apolipoproteins, which exhibit antibacterial activity and to nucleic acids encoding the same. The invention further provides the use of such polypeptides, derivatives, analogues or nucleic acids as medicaments, and also their use in methods of preventing or treating bacterial infection or objects and surfaces. The invention further extends to objects, such as contact lenses, coated with the polypeptides.

公开(公告)号：US20090169598A1

公开(公告)日：2009-07-02

申请号：US10586416

申请日：2005-02-28

申请人： Keith Alan Crutcher

发明人： Keith Alan Crutcher

IPC分类号： A61K9/00 ,  A61K38/17 ,  C07K7/00 ,  C07H21/04

CPC分类号： A61K38/1709 ,  Y02A50/469 ,  Y02A50/481

摘要： The invention relates to polypeptides, comprising repeats of peptides derived from apolipoproteins, which exhibit antibacterial activity and to nucleic acids encoding the same. The invention further provides the use of such polypeptides, derivatives, analogues or nucleic acids as medicaments, and also their use in methods of preventing or treating bacterial infection or objects and surfaces. The invention further extends to objects, such as contact lenses, coated with the polypeptides.

摘要翻译： 本发明涉及多肽，其包含衍生自表现出抗菌活性的载脂蛋白的肽的多肽和编码该肽的核酸。 本发明还提供了这种多肽，衍生物，类似物或核酸作为药物的用途，以及它们在预防或治疗细菌感染或物体和表面的方法中的用途。 本发明进一步扩展到涂覆有多肽的物体，例如隐形眼镜。