公开(公告)号：US20100204491A1

公开(公告)日：2010-08-12

申请号：US12762890

申请日：2010-04-19

Applicant: Ryu HIRATA ,  Tatsuya Matsukawa ,  Kazuchiro Masuzaki ,  Ryuji Ueno

Inventor： Ryu HIRATA ,  Tatsuya Matsukawa ,  Kazuchiro Masuzaki ,  Ryuji Ueno

IPC: C07D309/06

CPC classification number: C07D307/93 ,  C07C405/0025 ,  C07D307/935 ,  C07D309/12 ,  C07D311/94

Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.