公开(公告)号：US08497114B2

公开(公告)日：2013-07-30

申请号：US13395824

申请日：2010-09-17

申请人： Shizuki Kondo ,  Kanetada Shimizu

发明人： Shizuki Kondo ,  Kanetada Shimizu

IPC分类号： C12N1/12 ,  A01N63/00

CPC分类号： A23C9/1234 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2300/29 ,  A61K35/745 ,  C12N1/20 ,  C12R1/01 ,  A23V2200/332

摘要： An anti-obesity agent or a glucose tolerance-ameliorating agent containing a bacterium belonging to the genus Bifidobacterium as an active ingredient, wherein the bacterium belonging to the genus Bifidobacterium exhibits a conversion rate from linoleic acid into conjugated linoleic acid of not more than 10%. The present invention is able to provide an anti-obesity agent and a glucose tolerance-ameliorating agent that are effective for the prevention or treatment of obesity or the amelioration of glucose tolerance and also exhibit superior safety, as well as providing foods or beverages containing these agents. Further, the present invention is also able to provide a bacterium of the genus Bifidobacterium, and in particular a Bifidobacterium breve, that is effective for the prevention or treatment of obesity or the amelioration of glucose tolerance and also exhibits superior safety, as well as providing a pharmaceutical composition containing this bacterium.

摘要翻译： 含有属于双歧杆菌属的细菌的抗肥胖剂或葡萄糖耐量改善剂为活性成分，其中属于双歧杆菌属的细菌表现出从亚油酸至共轭亚油酸的转化率不超过10％ 。 本发明能够提供对于预防或治疗肥胖或改善葡萄糖耐量有效的抗肥胖剂和葡萄糖耐量改善剂，并且还表现出优异的安全性，以及提供含有这些的食品或饮料 代理商 此外，本发明还能够提供对预防或治疗肥胖或改善葡萄糖耐量有效的双歧杆菌属，特别是双歧杆菌属的细菌，并且还表现出优异的安全性，并且提供 含有这种细菌的药物组合物。

公开(公告)号：US09345743B2

公开(公告)日：2016-05-24

申请号：US14346050

申请日：2012-08-24

申请人： Hirotsugu Oda ,  Koji Yamauchi ,  Takumi Sato ,  Kanetada Shimizu

发明人： Hirotsugu Oda ,  Koji Yamauchi ,  Takumi Sato ,  Kanetada Shimizu

IPC分类号： A61K38/40 ,  A61K38/10 ,  C07K14/79 ,  A23L1/30 ,  A61K35/745 ,  A23L1/305 ,  A23L2/52 ,  A61K35/74 ,  C07K7/08

CPC分类号： A61K38/10 ,  A23L2/52 ,  A23L33/135 ,  A23L33/18 ,  A23V2002/00 ,  A23Y2300/29 ,  A23Y2300/45 ,  A61K35/74 ,  A61K35/745 ,  A61K38/40 ,  C07K7/08 ,  C07K14/79 ,  A61K2300/00

摘要： A peptide dimer comprising a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and a peptide consisting of any one of the amino acid sequences of SEQ ID NOS: 2 to 4, wherein the peptide consisting of the amino acid sequence of SEQ ID NO: 1 and the peptide consisting of any one of the amino acid sequences of SEQ ID NOS: 2 to 4 are bound through a disulfide bond between a cysteine residue of each peptide is used as an active ingredient of an agent for promoting proliferation of one or more bacterium selected from the group consisting of Bifidobacterium infantis and Bifidobacterium breve.

摘要翻译： 包含由SEQ ID NO：1的氨基酸序列组成的肽和由SEQ ID NO：2〜4的任一氨基酸序列组成的肽的肽二聚体，其中由SEQ ID NO：1的氨基酸序列组成的肽 ID NO：1，由SEQ ID NO：2〜4的任一氨基酸序列组成的肽通过二肽键结合，各肽的半胱氨酸残基被用作促进增殖的药剂的活性成分 一种或多种选自婴儿双歧杆菌和短双歧杆菌的细菌。

公开(公告)号：US08338161B2

公开(公告)日：2012-12-25

申请号：US12162705

申请日：2007-11-02

申请人： Kanetada Shimizu ,  Tomoko Yaeshima

发明人： Kanetada Shimizu ,  Tomoko Yaeshima

IPC分类号： C12N1/20

CPC分类号： C12N1/38 ,  A23C9/1234 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/49 ,  A23Y2300/55 ,  A61K35/744 ,  C12N1/20 ,  C12R1/46 ,  A23V2200/3204 ,  A23V2200/32

摘要： The present invention relates to bacteria of a genus Lactococcus having bacteriological properties of: (1) fermentability which curdles a 10% (W/W) reconstituted skim milk medium when cultivated at a temperature of 25° C. to 37° C. for 16 hours; (2) Bifidobacterium longum growth-promoting properties which lead to a viable count of Bifidobacterium longum of 5×108 CFU/g or more, when co-cultivated with Bifidobacterium longum in the 10% (W/W) reconstituted skim milk medium, until the pH thereof is 4.4 to 4.6; and (3) Bifidobacterium longum survivability-improving properties during storage, which lead to a survival rate of Bifidobacterium longum of 30% or more, after co-cultivation with Bifidobacterium longum in the 10% (W/W) reconstituted skim milk medium until the pH thereof is 4.4 to 4.6, rapid cooling, and two weeks storage at 10° C.

摘要翻译： 本发明涉及一种具有细菌学特性的细菌的细菌性质：（1）发酵能力，其在25℃至37℃的温度下培养16天时，将10％（W / W）重构脱脂乳培养基凝结为16 小时; （2）当在10％（W / W）重构的脱脂乳培养基中与长双歧杆菌共培养时，长双歧杆菌生长促进特性导致5×108CFU / g以上的长双歧杆菌的活菌计数直到 其pH为4.4〜4.6; 和（3）在长期保存双歧杆菌存活率方面，在10％（W / W）重构的脱脂乳培养基中与长双歧杆菌共同培养后，长寿双歧杆菌的存活率达30％以上，直至 pH值为4.4至4.6，快速冷却，并在10℃下储存两周。

公开(公告)号：US08277857B2

公开(公告)日：2012-10-02

申请号：US12810407

申请日：2009-04-17

申请人： Kanetada Shimizu ,  Sumiko Yonezawa

发明人： Kanetada Shimizu ,  Sumiko Yonezawa

IPC分类号： A23C9/12

CPC分类号： A23C9/1275 ,  A23C9/1234 ,  A23Y2300/55 ,  C12N1/20

摘要： The present invention provides a method for producing fermented milk, the method employing a lactic acid bacterium capable of improving proliferative properties of Bifidobacterium, and a fermented milk prepared by the production method. Specifically, the present invention provides a method for producing a fermented milk, including fermenting a fermentation base using both Lactococcus lactis strain having cell wall-enveloped proteinase, PrtP, and bacteria belonging to a genus Bifidobacterium, and a fermented milk prepared by the production method.

摘要翻译： 本发明提供发酵乳的制造方法，使用能够提高双歧杆菌的增殖性的乳酸菌的方法和通过该制造方法制备的发酵乳。 具体而言，本发明提供一种发酵乳的制造方法，其特征在于，使用具有细胞壁包膜蛋白酶的乳酸乳球菌乳酸菌PrtP和属于双歧杆菌属的细菌的发酵基质和通过制造方法制备的发酵乳 。

公开(公告)号：US20100247711A1

公开(公告)日：2010-09-30

申请号：US12600096

申请日：2009-03-11

申请人： Kanetada Shimizu ,  Kazuya Murakami ,  Sachiko Takahashi ,  Yuta Hirano ,  Tatsuya Itou ,  Naoki Susaki

发明人： Kanetada Shimizu ,  Kazuya Murakami ,  Sachiko Takahashi ,  Yuta Hirano ,  Tatsuya Itou ,  Naoki Susaki

IPC分类号： A23C9/12

CPC分类号： A23C9/137 ,  A23C9/1234 ,  A23L29/244 ,  A23L33/135 ,  A23V2002/00 ,  A23V2250/5062

摘要： An acidic lactic acid bacteria beverage having a favorable flavor and an improved survival rate for bifidobacteria. The acidic lactic acid bacteria beverage of the present invention includes bifidobacteria and inulin, wherein the inulin is not fermented by the bifidobacteria. The inulin content is preferably within a range from 1 to 10% by mass, and the pH of the acidic lactic acid bacteria beverage is preferably within a range from 4.1 to 4.8.

摘要翻译： 具有良好风味的酸性乳酸菌饮料和双歧杆菌的存活率提高。 本发明的酸性乳酸菌饮料包括双歧杆菌和菊粉，其中菊粉不被双歧杆菌发酵。 菊粉含量优选在1〜10质量％的范围内，酸性乳酸菌饮料的pH优选在4.1〜4.8的范围内。

公开(公告)号：US20120171167A1

公开(公告)日：2012-07-05

申请号：US13395824

申请日：2010-09-17

申请人： Shizuki Kondo ,  Kanetada Shimizu

发明人： Shizuki Kondo ,  Kanetada Shimizu

IPC分类号： A61K35/74 ,  A61P3/04 ,  A61P3/08 ,  C12N1/20

CPC分类号： A23C9/1234 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2300/29 ,  A61K35/745 ,  C12N1/20 ,  C12R1/01 ,  A23V2200/332

摘要： An anti-obesity agent or a glucose tolerance-ameliorating agent containing a bacterium belonging to the genus Bifidobacterium as an active ingredient, wherein the bacterium belonging to the genus Bifidobacterium exhibits a conversion rate from linoleic acid into conjugated linoleic acid of not more than 10%. The present invention is able to provide an anti-obesity agent and a glucose tolerance-ameliorating agent that are effective for the prevention or treatment of obesity or the amelioration of glucose tolerance and also exhibit superior safety, as well as providing foods or beverages containing these agents. Further, the present invention is also able to provide a bacterium of the genus Bifidobacterium, and in particular a Bifidobacterium breve, that is effective for the prevention or treatment of obesity or the amelioration of glucose tolerance and also exhibits superior safety, as well as providing a pharmaceutical composition containing this bacterium.

摘要翻译： 含有属于双歧杆菌属的细菌的抗肥胖剂或葡萄糖耐量改善剂为活性成分，其中属于双歧杆菌属的细菌表现出从亚油酸至共轭亚油酸的转化率不超过10％ 。 本发明能够提供对于预防或治疗肥胖或改善葡萄糖耐量有效的抗肥胖剂和葡萄糖耐量改善剂，并且还表现出优异的安全性，以及提供含有这些的食品或饮料 代理商 此外，本发明还能够提供对预防或治疗肥胖或改善葡萄糖耐量有效的双歧杆菌属，特别是双歧杆菌属的细菌，并且还表现出优异的安全性，并且提供 含有这种细菌的药物组合物。

公开(公告)号：US20100086988A1

公开(公告)日：2010-04-08

申请号：US12162705

申请日：2007-11-02

申请人： Kanetada Shimizu ,  Tomoko Yaeshima

发明人： Kanetada Shimizu ,  Tomoko Yaeshima

IPC分类号： C12N1/20

CPC分类号： C12N1/38 ,  A23C9/1234 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/49 ,  A23Y2300/55 ,  A61K35/744 ,  C12N1/20 ,  C12R1/46 ,  A23V2200/3204 ,  A23V2200/32

摘要： The present invention relates to bacteria of a genus Lactococcus having bacteriological properties of: (1) fermentability which curdles a 10% (W/W) reconstituted skim milk medium when cultivated at a temperature of 25° C. to 37° C. for 16 hours; (2) Bifidobacterium longum growth-promoting properties which lead to a viable count of Bifidobacterium longum of 5×108 CFU/g or more, when co-cultivated with Bifidobacterium longum in the 10% (W/W) reconstituted skim milk medium, until the pH thereof is 4.4 to 4.6; and (3) Bifidobacterium longum survivability-improving properties during storage, which lead to a survival rate of Bifidobacterium longum of 30% or more, after co-cultivation with Bifidobacterium longum in the 10% (W/W) reconstituted skim milk medium until the pH thereof is 4.4 to 4.6, rapid cooling, and two weeks storage at 10° C.

摘要翻译： 本发明涉及一种具有细菌学特性的细菌的细菌性质：（1）发酵能力，其在25℃至37℃的温度下培养16天时，将10％（W / W）重构脱脂乳培养基凝结为16 小时; （2）当在10％（W / W）重构的脱脂乳培养基中与长双歧杆菌共培养时，长双歧杆菌生长促进特性导致5×108CFU / g以上的长双歧杆菌的活菌计数直到 其pH为4.4〜4.6; 和（3）在长期保存双歧杆菌存活率方面，在10％（W / W）重构的脱脂乳培养基中与长双歧杆菌共同培养后，长寿双歧杆菌的存活率达30％以上，直至 pH值为4.4至4.6，快速冷却，并在10℃下储存两周。

公开(公告)号：US20090170772A1

公开(公告)日：2009-07-02

申请号：US12295091

申请日：2007-03-08

申请人： Noriyuki Iwabuchi ,  Kanetada Shimizu ,  Noritoshi Takahashi

发明人： Noriyuki Iwabuchi ,  Kanetada Shimizu ,  Noritoshi Takahashi

IPC分类号： A61K38/16 ,  C12P21/00 ,  C07K14/00 ,  A61P3/10

CPC分类号： A23K10/16 ,  A23L33/135 ,  A61K35/745

摘要： An object is to provide an interleukin production regulator which can be used for prevention, treatment or recurrence prevention of a gastrointestinal disease or an autoimmune disease accompanied by an inflammation as the main symptom, which is highly safe, and which can be administered over a long period. Another object is to provide a method for production of the interleukin production regulator. Further object is to provide a pharmaceutical composition and a food, each of which comprises the interleukin production regulator.Disclosed are: a method for producing an interleukin production regulator having both an effect of maintaining or promoting the production of interleukin-10 and an effect of maintaining or inhibiting the production of interleukin-12, comprising the step of disrupting a cell of a microorganism belonging to the genus Bifidobacterium; an interleukin production regulator produced by the method; and a pharmaceutical and a food, each comprising the interleukin production regulator.

摘要翻译： 本发明的目的是提供一种可用于预防，治疗或复发的预防，治疗或复发预防胃肠疾病或伴有炎症的自身免疫性疾病作为主要症状，其是高度安全的，并且可以长时间施用 期。 另一个目的是提供一种生产白介素产生调节剂的方法。 另外的目的是提供一种药物组合物和食品，其中每一种都包含白介素产生调节剂。 本发明公开了一种具有维持或促进白细胞介素-10的产生的效果的白细胞介素产生调节剂的制造方法和维持或抑制白细胞介素-12的产生的效果的方法，其特征在于，包括使所述微生物的细胞破碎的步骤 到双歧杆菌属; 通过该方法生产的白介素生产调节剂; 以及药物和食品，各自包含白介素产生调节剂。

公开(公告)号：US20090035416A1

公开(公告)日：2009-02-05

申请号：US12278804

申请日：2007-11-01

申请人： Kanetada Shimizu ,  Kazuhiro Miyaji ,  Kouichi Ogawa ,  Yoshiaki Kiso ,  Takako Ishida

发明人： Kanetada Shimizu ,  Kazuhiro Miyaji ,  Kouichi Ogawa ,  Yoshiaki Kiso ,  Takako Ishida

IPC分类号： A23C9/12

CPC分类号： A23C9/1234 ,  A23Y2220/00 ,  A23Y2240/41 ,  A23Y2300/55

摘要： The present invention relates to a method for producing a fermented milk, including: performing fermentation using both bacteria belonging to the genus Bifidobacterium and bacteria belonging to the genus Lactococcus as lactic acid bacteria, wherein the bacteria belonging to the genus Lactococcus have the following bacteriological properties: (1) fermentability which curdles a 10% (W/W) reconstituted skim milk medium when cultivated at a temperature of 25° C. to 37° C. for 16 hours; (2) Bifidobacterium longum growth-promoting properties which lead to a viable count of Bifidobacterium longum of 5×108 CFU/g or more, when co-cultivated with Bifidobacterium longum in the 10% (W/W) reconstituted skim milk medium until the pH thereof is 4.4 to 4.6; and (3) Bifidobacterium longum survivability-improving properties during storage, which lead to a survival rate of Bifidobacterium longum of 30% or more, after co-cultivation with Bifidobacterium longum in the 10% (W/W) reconstituted skim milk medium until the pH thereof is 4.4 to 4.6, rapid cooling, and two weeks storage at 10° C., and also relates to a fermented milk prepared by the production method.

摘要翻译： 发酵乳的制造方法技术领域本发明涉及发酵乳的制造方法，其特征在于，使用属于双歧杆菌属的细菌和属于乳球菌属的细菌进行发酵，作为乳酸菌，其中属于乳球菌属的细菌具有以下细菌学特性 ：（1）发酵能力，其在25℃至37℃的温度下培养16小时时，将10％（W / W）重构脱脂乳培养基凝结; （2）当在10％（W / W）重构的脱脂乳培养基中与长双歧杆菌共培养直至其pH值达到5×10 8 CFU / g以上时，长双歧杆菌生长促进性能导致5×10 8 CFU / g以上的长双歧杆菌活菌数 为4.4〜4.6; 和（3）在长期保存双歧杆菌存活率方面，在10％（W / W）重构的脱脂乳培养基中与长双歧杆菌共同培养后，长寿双歧杆菌的存活率达30％以上，直至 pH为4.4〜4.6，快速冷却，在10℃保存2周，也涉及通过该制造方法制备的发酵乳。

公开(公告)号：US09060529B2

公开(公告)日：2015-06-23

申请号：US13577167

申请日：2011-01-31

申请人： Motomitsu Kitaoka ,  Mamoru Nishimoto ,  Kanetada Shimizu

发明人： Motomitsu Kitaoka ,  Mamoru Nishimoto ,  Kanetada Shimizu

IPC分类号： A61K31/7016 ,  A61K31/70 ,  A61K8/60 ,  A23K1/16 ,  A23L1/09 ,  A23K3/00 ,  A61K9/00

CPC分类号： A23K1/1643 ,  A23K20/163 ,  A23K30/00 ,  A23L5/00 ,  A23L29/30 ,  A23L33/125 ,  A23V2002/00 ,  A61K9/0095 ,  A23V2250/28 ,  A23V2200/3202

摘要： The present invention relates to a method of treating a liquid composition containing lacto-N-biose, the method including: preparing a liquid composition containing lacto-N-biose having a pH at 25° C. of not less than 2.0 and not more than 5.5, and heating the liquid composition at a temperature of 65° C. or higher. The present invention can provide a treatment method that enables thermal decomposition of lacto-N-biose to be suppressed when a liquid composition containing lacto-N-biose is heated at a temperature of 65° C. or higher, a liquid preparation containing lacto-N-biose that is treated using the treatment method, a dried product produced from such a liquid preparation containing lacto-N-biose, and a method of producing a product containing lacto-N-biose.

摘要翻译： 本发明涉及一种处理含有乳-N-生物的液体组合物的方法，所述方法包括：制备含有乳酸-N-生物的液体组合物，所述乳-N-生物在25℃下的pH为2.0以上且不大于 5.5，在65℃以上的温度下加热液体组合物。 本发明可以提供一种处理方法，当含有乳-N-生物的液体组合物在65℃以上的温度下加热时，能够抑制乳-N-降血糖的热分解， 使用处理方法处理的N-生物，由含有乳-N-生物的液体制剂制备的干燥产物，以及含有乳-N-生物的产品的制造方法。